The relationship between ferroptosis and respiratory infectious diseases: a novel landscape for therapeutic approach DOI Creative Commons

Hong Lin,

Xiangyu Chen, Yiming Liu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 18, 2025

Respiratory infectious diseases, particularly those caused by respiratory viruses, have the potential to lead global pandemics, thereby posing significant threats public and human health. Historically, primary treatment for bacterial infections has been antibiotic therapy, while severe cases of viral predominantly managed controlling inflammatory cytokine storms. Ferroptosis is a novel form programmed cell death that distinct from apoptosis autophagy. In recent years, Recent studies demonstrated ferroptosis plays regulatory role in various indicating targeting may represent approach these conditions. This article summarized toxic mechanisms underlying ferroptosis, its relationship with action, current strategies. Particular attentions were given interplay between Mycobacterium tuberculosis, Epstein-Barr virus, acute syndrome coronavirus-2, Pseudomonas aeruginosa, dengue influenza virus herpes simplex type1infection. A deeper understanding will not only advance our knowledge infection-related pathophysiology but also provide theoretical foundation development therapeutic Targeting pathways represents promising infections, clinical translational implications.

Язык: Английский

Post-translational modifications as a key mechanism for herpes simplex virus type I evasion of host innate immunity DOI Creative Commons
Yongxing Zhang, Jingying Xie, Ying Feng

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Фев. 11, 2025

Herpes simplex virus type 1 (HSV-1) is a DNA that infects humans and establishes long-term latency within the host. Throughout its prolonged interaction with host, HSV-1 evades innate immune system by encoding own proteins. Post-translational modifications (PTMs) of these proteins play crucial roles in their function, activity, interactions other factors modifying specific amino acids, thereby enabling diverse range protein functions. This review explores mechanisms PTMs HSV-1-encoded proteins, such as phosphorylation, ubiquitination, deamidation, SUMOylation, during infection latency. These are essential for suppressing host immunity, facilitating viral replication, elucidating crosstalk among various post-translational modifications.

Язык: Английский

Процитировано

0
Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity DOI Creative Commons

Xuemin Lü,

Yabin Wu,

Chao Zhao

и другие.

FEBS Open Bio, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Self‐amplifying RNA (saRNA) vectors have garnered significant attention for their potential in transient recombinant protein expression and vaccination strategies. These are notable safety the ability to produce high levels of from minimal input templates, offering a promising avenue gene therapy applications. Despite advantages, saRNA face critical challenge propensity trigger robust innate immune response. The presence double‐stranded intermediates during replication activates pattern recognition receptors (PRRs), leading activation kinase R (PKR) interferon (IFN) signaling, which can result general translational shutdown within host cell. To mitigate stimulatory effects on PRRs enhance translation efficiency saRNA, this study employs saRNA‐encoding HSV‐1 neurovirulence ICP34.5, is known its counteract PKR activation, potentially improving saRNA. It was shown that ICP34.5 clearly mediated eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation suppression responses vitro , enhanced saRNA‐encoded genes. application incorporating offers more efficient cost‐effective solution production proteins development vaccines. This strategy could revolutionize fields where utilization envisioned, particularly neurotropic disease applications may offer additional benefits.

Язык: Английский

Процитировано

0
The relationship between ferroptosis and respiratory infectious diseases: a novel landscape for therapeutic approach DOI Creative Commons

Hong Lin,

Xiangyu Chen, Yiming Liu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 18, 2025

Respiratory infectious diseases, particularly those caused by respiratory viruses, have the potential to lead global pandemics, thereby posing significant threats public and human health. Historically, primary treatment for bacterial infections has been antibiotic therapy, while severe cases of viral predominantly managed controlling inflammatory cytokine storms. Ferroptosis is a novel form programmed cell death that distinct from apoptosis autophagy. In recent years, Recent studies demonstrated ferroptosis plays regulatory role in various indicating targeting may represent approach these conditions. This article summarized toxic mechanisms underlying ferroptosis, its relationship with action, current strategies. Particular attentions were given interplay between Mycobacterium tuberculosis, Epstein-Barr virus, acute syndrome coronavirus-2, Pseudomonas aeruginosa, dengue influenza virus herpes simplex type1infection. A deeper understanding will not only advance our knowledge infection-related pathophysiology but also provide theoretical foundation development therapeutic Targeting pathways represents promising infections, clinical translational implications.

Язык: Английский

Процитировано

0