Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis DOI Creative Commons
Julie Le Naour, Léa Montégut, Yuhong Pan

и другие.

OncoImmunology, Год журнала: 2023, Номер 12(1)

Опубликована: Июль 21, 2023

Formyl peptide receptor-1 (FPR1) is a pattern recognition receptor that mostly expressed by myeloid cells. In patients with colorectal cancer (CRC), loss-of-function polymorphism (rs867228) in the gene coding for FPR1 has been associated reduced responses to chemotherapy or chemoradiotherapy. Moreover, rs867228 accelerated esophageal and carcinogenesis. Here, we show dendritic cells from Fpr1-/- mice exhibit migration response chemotherapy-treated CRC are particularly susceptible chronic ulcerative colitis oncogenesis induced mutagen azoxymethane followed oral dextran sodium sulfate, detergent induces colitis. These experiments were performed after initial co-housing of wild-type controls, precluding major Fpr1-driven differences microbiota. Pharmacological inhibition Fpr1 cyclosporin H also tended increase intestinal bearing ApcMin mutation, this effect was reversed anti-inflammatory drug sulindac. We conclude defective signaling favors tumorigenesis through modulation innate inflammatory/immune response.

Язык: Английский

Targeting immunogenic cell stress and death for cancer therapy DOI
Lorenzo Galluzzi, Emma Guilbaud,

Darby Schmidt

и другие.

Nature Reviews Drug Discovery, Год журнала: 2024, Номер 23(6), С. 445 - 460

Опубликована: Апрель 15, 2024

Язык: Английский

Процитировано

77
Immunosurveillance in clinical cancer management DOI Open Access
Guido Kroemer, Timothy A. Chan, Alexander M.M. Eggermont

и другие.

CA A Cancer Journal for Clinicians, Год журнала: 2023, Номер 74(2), С. 187 - 202

Опубликована: Окт. 25, 2023

The progression of cancer involves a critical step in which malignant cells escape from control by the immune system. Antineoplastic agents are particularly efficient when they succeed restoring such (immunosurveillance) or at least establish an equilibrium state that slows down disease progression. This is true not only for immunotherapies, as checkpoint inhibitors (ICIs), but also conventional chemotherapy, targeted anticancer agents, and radiation therapy. Thus, therapeutics stress kill while provoking tumor-targeting response, referred to immunogenic cell death, useful combination with ICIs. Modern oncology regimens increasingly using combinations, chemoimmunotherapy, well combinations multiple However, latter generally associated severe side effects compared single-agent Of note, success these combinatorial strategies against locally advanced metastatic cancers now spurring successful attempts move them past postoperative (adjuvant) setting preoperative (neoadjuvant) setting, even patients operable cancers. Here, authors critically discuss importance immunosurveillance modern clinical management.

Язык: Английский

Процитировано

59
FPR1: A critical gatekeeper of the heart and brain DOI Creative Commons

Ziyin Zhangsun,

Yushu Dong,

Jiayou Tang

и другие.

Pharmacological Research, Год журнала: 2024, Номер 202, С. 107125 - 107125

Опубликована: Март 2, 2024

G protein-coupled receptors (GPCRs) are currently the most widely focused drug targets in clinic, exerting their biological functions by binding to chemicals and activating a series of intracellular signaling pathways. Formyl-peptide receptor 1 (FPR1) has typical seven-transmembrane structure GPCRs can be stimulated large number endogenous or exogenous ligands with different chemical properties, first which was identified as formyl-methionine-leucyl-phenylalanine (fMLF). Through receptor-ligand interactions, FPR1 is involved inflammatory response, immune cell recruitment, cellular regulation key types, including neutrophils, neural stem cells (NSCs), microglia. This review outlines critical roles variety heart brain diseases, myocardial infarction (MI), ischemia/reperfusion (I/R) injury, neurodegenerative neurological tumors, particular emphasis on milestones agonists antagonists. Therefore, an in-depth study contributes research innovative biomarkers therapeutic for well clinical applications.

Язык: Английский

Процитировано

8
Immunogenic cell death (ICD) enhancers—Drugs that enhance the perception of ICD by dendritic cells DOI Creative Commons
Peng Liu, Liwei Zhao, Laurence Zitvogel

и другие.

Immunological Reviews, Год журнала: 2023, Номер 321(1), С. 7 - 19

Опубликована: Авг. 19, 2023

The search for immunostimulatory drugs applicable to cancer immunotherapy may profit from target-agnostic methods in which agents are screened their functional impact on immune cells cultured vitro without any preconceived idea mode of action. We have built a synthetic mini-immune system stressed and dying (derived standardized cell lines) confronted with dendritic (DCs, derived immortalized precursors) CD8

Язык: Английский

Процитировано

12
The danger theory of immunity revisited DOI
Guido Kroemer, Léa Montégut, Oliver Kepp

и другие.

Nature reviews. Immunology, Год журнала: 2024, Номер 24(12), С. 912 - 928

Опубликована: Ноя. 7, 2024

Язык: Английский

Процитировано

4
The N-formyl peptide receptors: much more than chemoattractant receptors. Relevance in health and disease DOI Creative Commons
Filomena Napolitano, Nunzia Montuori

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 4, 2025

Pattern Recognition Receptors (PRRs) are a superfamily of receptors that detect molecular structures typical for pathogens and damaged cells play crucial role in the proper function innate immune system. A particular subgroup membrane-bound PRRs is represented by N-formyl peptide (FPRs) consist transmembrane G-protein coupled involved inflammatory responses. FPRs were initially described as transducers chemotactic signals phagocytes react to tissue injury. Subsequently, also identified wide variety cell types, including cancer cells. Beyond broad cellular distribution, characterized ability bind ligands with different chemical biological properties, ranging from natural peptides synthetic compounds. The binding specific agonists induces cascade functional events, such proliferation, migration, angiogenesis, oxidative stress. From all this evidence, it becomes clear multifaceted several pathophysiological processes associated inflammation. In review, we provide comprehensive description structure-function relationship their pivotal host defense, highlighting regulatory functions both initiation resolution addition activity during response, focus on involvement pathological conditions, chronic disease, neurodegenerative disorders, cancer, special emphasis FPR targeting promising therapeutic strategies era precision medicine.

Язык: Английский

Процитировано

0
Formyl peptide receptor-1 (FPR1) represses intestinal oncogenesis DOI Creative Commons
Julie Le Naour, Léa Montégut, Yuhong Pan

и другие.

OncoImmunology, Год журнала: 2023, Номер 12(1)

Опубликована: Июль 21, 2023

Formyl peptide receptor-1 (FPR1) is a pattern recognition receptor that mostly expressed by myeloid cells. In patients with colorectal cancer (CRC), loss-of-function polymorphism (rs867228) in the gene coding for FPR1 has been associated reduced responses to chemotherapy or chemoradiotherapy. Moreover, rs867228 accelerated esophageal and carcinogenesis. Here, we show dendritic cells from Fpr1-/- mice exhibit migration response chemotherapy-treated CRC are particularly susceptible chronic ulcerative colitis oncogenesis induced mutagen azoxymethane followed oral dextran sodium sulfate, detergent induces colitis. These experiments were performed after initial co-housing of wild-type controls, precluding major Fpr1-driven differences microbiota. Pharmacological inhibition Fpr1 cyclosporin H also tended increase intestinal bearing ApcMin mutation, this effect was reversed anti-inflammatory drug sulindac. We conclude defective signaling favors tumorigenesis through modulation innate inflammatory/immune response.

Язык: Английский

Процитировано

5