Antigenic Imprinting Dominates Humoral Responses to New Variants of SARS-CoV-2 in a Hamster Model of COVID-19 DOI Creative Commons

Joran Degryse,

Elke Maas, Ria Lassaunière

и другие.

Microorganisms, Год журнала: 2024, Номер 12(12), С. 2591 - 2591

Опубликована: Дек. 14, 2024

The emergence of SARS-CoV-2 variants escaping immunity challenges the efficacy current vaccines. Here, we investigated humoral recall responses and vaccine-mediated protection in Syrian hamsters immunized with third-generation Comirnaty® Omicron XBB.1.5-adapted COVID-19 mRNA vaccine, followed by infection either antigenically closely (EG.5.1) or distantly related (JN.1) subvariants. Vaccination YF17D vector encoding a modified Gamma spike (YF-S0*) served as control for restricted to pre-Omicron variants. Our results show that both XBB.1.5 YF-S0* induce robust, however, poorly cross-reactive, neutralizing antibody (nAb) responses. In case, total nAb levels increased following infection. Intriguingly, specificity these boosted nAbs did not match respective challenge virus, but was skewed towards primary antigen used immunization, suggesting marked impact antigenic imprinting, confirmed cartography. Furthermore, limited cross-reactivity rapid decline induced EG.5.1 and, more concerning, JN.1, raises doubts about sustained vaccine against recent circulating conclusion, demonstrate imprinting plays dominant role shaping emerging Future design may have address two major issues: (i) overcoming original sin limits breadth protective response variants, (ii) achieving lasts at least one season.

Язык: Английский

Virus-Induced Pathogenic Antibodies: Lessons from Long COVID and Dengue Hemorrhage Fever DOI Open Access
Der‐Shan Sun,

Te-Sheng Lien,

Hsin‐Hou Chang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1898 - 1898

Опубликована: Фев. 22, 2025

Virus-induced antibodies represent a dual-edged sword in the immune response to viral infections. While are critical for neutralizing pathogens, some can paradoxically exacerbate disease severity through mechanisms such as antibody-dependent enhancement (ADE), autoantibody, and prolonged inflammation. Long coronavirus (COVID) dengue hemorrhagic fever (DHF) exemplify conditions where pathogenic play pivotal role progression. COVID is associated with persistent dysregulation autoantibody production, leading chronic symptoms tissue damage. In DHF, pre-existing against virus contribute ADE, amplifying replication, activation, vascular permeability. This review explores underlying these antibody responses, highlighting shared pathways of comparing distinct features both conditions. By examining studies, we identify key lessons therapeutic strategies, vaccine design, future research aimed at mitigating severe outcomes

Язык: Английский

Процитировано

0
Systemic and Mucosal Antibody Responses to SARS-CoV-2 Variant-Specific Prime-and-Boost and Prime-and-Spike Vaccination: A Comparison of Intramuscular and Intranasal Bivalent Vaccine Administration in a Murine Model DOI Creative Commons
Mariam Maltseva,

Yannick Galipeau,

Pauline S. McCluskie

и другие.

Vaccines, Год журнала: 2025, Номер 13(4), С. 351 - 351

Опубликована: Март 25, 2025

Background: The rapid genetic evolution of SARS-CoV-2 has led to the emergence immune-evading, highly transmissible variants concern (VOCs). This prompts need for next-generation vaccines that elicit robust mucosal immunity in airways directly curb viral infection. Objective: Here, we investigate impact heterologous variant prime–boost regimens on humoral responses, focusing intramuscular (IM) and intranasal (IN) routes administration. Using a murine model, assessed immunogenicity unadjuvanted protein boosts with Wu-1, Omicron BA.4/5, or Wu-1 + BA.4/5 spike antigens following monovalent bivalent IM priming mRNA-LNP vaccines. Results: induced strong systemic total neutralizing antibody responses were further enhanced by IN BA.4/5. boosting achieved broadest serum neutralization across all VOCs tested. Notably, robust, cross-variant production, independent subsequent boost combinations. Conclusions: Our findings highlight benefit including distinct antigenic prime vaccination followed variant-tailored both variant-specific are potentially capable reducing transmission.

Язык: Английский

Процитировано

0
Beyond the Pandemic Era: Recent Advances and Efficacy of SARS-CoV-2 Vaccines Against Emerging Variants of Concern DOI Creative Commons
Ankita Saha, Sounak Ghosh Roy, Richa Dwivedi

и другие.

Vaccines, Год журнала: 2025, Номер 13(4), С. 424 - 424

Опубликована: Апрель 17, 2025

Vaccination has been instrumental in curbing the transmission of SARS-CoV-2 and mitigating severity clinical manifestations associated with COVID-19. Numerous COVID-19 vaccines have developed to this effect, including BioNTech-Pfizer Moderna’s mRNA vaccines, as well adenovirus vector-based such Oxford–AstraZeneca. However, emergence new variants subvariants SARS-CoV-2, characterized by enhanced transmissibility immune evasion, poses significant challenges efficacy current vaccination strategies. In review, we aim comprehensively outline landscape emerging concern (VOCs) sub-lineages that recently surfaced post-pandemic years. We assess effectiveness existing their booster doses, against these subvariants, BA.2-derived sub-lineages, XBB BA.2.86 (Pirola). Furthermore, discuss latest advancements vaccine technology, multivalent pan-coronavirus approaches, along development several next-generation coronavirus exosome-based, virus-like particle (VLP), mucosal, nanomaterial-based vaccines. Finally, highlight key critical areas for future research address evolving threat develop strategies combating viral threats, thereby improving preparedness pandemics.

Язык: Английский

Процитировано

0
Contribution of immunoglobulin products in influencing seasonal influenza infection and severity in antibody immune deficiency patients receiving immunoglobulin replacement therapy DOI Creative Commons

Mark Ballow,

Raúl Ortiz-de-Lejarazu,

Isabella Quinti

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 22, 2024

Seasonal and pandemic influenza infection present a potential threat to patients with antibody deficiency. The acceptance effect of the current recommendation for annual vaccination against deficiency is not well investigated due antigenic drift or shift protective capacity regular IgG replacement therapy (IgRT) considered low. This narrative review considers in immunodeficient discusses available information on immunoglobulin products seasonal infectivity severity receiving IgRT. humoral immune response reduced However, there no evidence that proportion primary who develop illness, such increased when compared general population. IgRT receive has been shown contain neutralizing antibodies as consequence past flu infections both hemagglutinin neuraminidase surface proteins other viral internal different A virus strains. Studies have demonstrated only significant levels specific but also cross-reactive Thus, despite yearly changes antigenicity occur, could potentially contribute protection influenza. Currently, limited clinical data are confirming preventative respect infection. In conclusion, some antibody-related immunodeficiency. additional needed confirm extent relevance this identify main responsible targets protection.

Язык: Английский

Процитировано

1
K. pneumoniae ghosts serve as a novel vaccine formulation to enhance immune responses of A. baumannii subunit vaccine in mice DOI

Zhongtian Zhu,

Ziyan Zhou,

Tianyi Zhu

и другие.

Microbial Pathogenesis, Год журнала: 2024, Номер unknown, С. 107226 - 107226

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1
Editorial on: Protection against influenza hospitalizations from enhanced influenza vaccines among older adults: A systematic review and network meta‐analysis DOI Open Access
Melissa K. Andrew, Allison McGeer

Journal of the American Geriatrics Society, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

See related articles by Ferdinands et al .

Язык: Английский

Процитировано

0
A polygeneric immunogen composed of 22 venoms from sub-Saharan African snakes to expand the neutralization scope of the EchiTAb-plus-ICP antivenom DOI Creative Commons
Andrés Sánchez,

Gina Durán,

Maykel Cerdas

и другие.

Toxicon X, Год журнала: 2024, Номер 24, С. 100213 - 100213

Опубликована: Ноя. 16, 2024

Recent research suggests that a polygeneric immunogen made from the venoms of most medically important viperid and elapid snakes in sub-Saharan Africa could elicit broader antibody response horses compared to current EchiTAb-plus-ICP antivenom, especially against neurotoxic venoms. To test this, 25 have been regularly immunized produce this antivenom were reimmunized with an containing 22 various snake species genera

Язык: Английский

Процитировано

0
Antigenic Imprinting Dominates Humoral Responses to New Variants of SARS-CoV-2 in a Hamster Model of COVID-19 DOI Creative Commons

Joran Degryse,

Elke Maas, Ria Lassaunière

и другие.

Microorganisms, Год журнала: 2024, Номер 12(12), С. 2591 - 2591

Опубликована: Дек. 14, 2024

The emergence of SARS-CoV-2 variants escaping immunity challenges the efficacy current vaccines. Here, we investigated humoral recall responses and vaccine-mediated protection in Syrian hamsters immunized with third-generation Comirnaty® Omicron XBB.1.5-adapted COVID-19 mRNA vaccine, followed by infection either antigenically closely (EG.5.1) or distantly related (JN.1) subvariants. Vaccination YF17D vector encoding a modified Gamma spike (YF-S0*) served as control for restricted to pre-Omicron variants. Our results show that both XBB.1.5 YF-S0* induce robust, however, poorly cross-reactive, neutralizing antibody (nAb) responses. In case, total nAb levels increased following infection. Intriguingly, specificity these boosted nAbs did not match respective challenge virus, but was skewed towards primary antigen used immunization, suggesting marked impact antigenic imprinting, confirmed cartography. Furthermore, limited cross-reactivity rapid decline induced EG.5.1 and, more concerning, JN.1, raises doubts about sustained vaccine against recent circulating conclusion, demonstrate imprinting plays dominant role shaping emerging Future design may have address two major issues: (i) overcoming original sin limits breadth protective response variants, (ii) achieving lasts at least one season.

Язык: Английский

Процитировано

0