Infection with SARS-CoV-2 during the first trimester did not adversely impact perinatal and obstetric outcomes subsequent to in vitro fertilization with frozen embryo transfer: a retrospective cohort study

Journal of Assisted Reproduction and Genetics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

Язык: Английский

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The characterization of CD8 ⁺ T-cell responses in COVID-19

Emerging Microbes & Infections, Год журнала: 2023, Номер 13(1)

Опубликована: Ноя. 22, 2023

This review gives an overview of the protective role CD8+ T cells in SARS-CoV-2 infection. The cross-reactive responses intermediated by unexposed cohorts are described. Additionally, relevance resident upper and lower airway during infection is discussed, T-cell following vaccination, including recent worrisome breakthrough infections variants concerns (VOCs). Lastly, we explained correlation between COVID-19 severity. aids a deeper comprehension association broadens vision for future exploration.

Язык: Английский

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Peripheral PD-1+NK cells could predict the 28-day mortality in sepsis patients

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 17, 2024

Background Unbalanced inflammatory response is a critical feature of sepsis, life-threatening condition with significant global health burdens. Immune dysfunction, particularly that involving different immune cells in peripheral blood, plays crucial pathophysiological role and shows early warning signs sepsis. The objective to explore the relationship between sepsis subpopulations identify patients higher risk 28-day mortality based on immunological subtypes machine-learning (ML) model. Methods Patients were enrolled according sepsis-3 criteria this retrospective observational study, along age- sex-matched healthy controls (HCs). Data clinical characteristics, laboratory tests, lymphocyte immunophenotyping collected. XGBoost k-means clustering as ML approaches, employed analyze profiles stratify septic their subtypes. Cox regression survival analysis was used potential biomarkers assess association mortality. accuracy for determined by area under receiver operating characteristic (ROC) curve (AUC) analysis. Results study 100 89 HCs, revealing distinct two groups. model discriminated from HCs an 1.0 0.99 training testing set, respectively. Within model, top three highest important contributions percentage CD38 + CD8 T cells, PD-1 NK HLA-DR cells. Two clusters conducted. Cluster 1 featured proportions PD1 while cluster 2 naïve CD4 Furthermore, level significantly non-survivors than survivors (15.1% vs 8.6%, P <0.01). Moreover, levels combined SOFA score showed good performance predicting (AUC=0.91,95%CI 0.82–0.99), which superior only(AUC=0.69, sensitivity 0.74, specificity 0.64, cut-off value 11.25%). In multivariate regression, high expression proportion related (aHR=1.34, 95%CI 1.19 1.50; <0.001). Conclusion provides novel insights into cell prognosis Peripheral could potentially those

Язык: Английский

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Linking COVID-19 and cancer: Underlying mechanism

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1871(1), С. 167563 - 167563

Опубликована: Ноя. 5, 2024

Язык: Английский

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Exploring the impact of acute viral exposure on clinical characteristics and antibody profiles in antiphospholipid syndrome: a study in CAPSTONE

Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Июнь 18, 2024

Abstract The relationship between antiphospholipid syndrome (APS) and acute viral infection, such as SARS-CoV-2, is unclear. This study aims to assess symptoms, antibody (aPL) fluctuations, complication risks in APS patients infected with SARS-CoV-2. from Peking Union Medical College Hospital during the COVID-19 outbreak (October–December 2022) were included. Age- gender-matched without infection served controls. Data on demographics, treatments, serum aPL levels analyzed. Of 234 patients, 107 (45.7%) Typical symptoms included high fever (81.3%), cough/expectoration (70.1%), pharyngalgia (52.3%). gender-based matching selected 97 either or uninfected group. After anti-β-2-glycoprotein I-IgG (aβ2GP1-IgG) increased 4.14 4.18 AU/ml, aβ2GP1-IgM decreased 9.85 7.38 anticardiolipin-IgA (aCL-IgA) significantly a median remaining at 2.50 APLU/ml. Lupus anticoagulants other aPLs remained stable. Arterial thrombosis incidence 18 (18.6%) 21 (21.6%), while venous did not change. Additionally, 7 (6.5%) presented new-onset worsening thrombocytopenia, characterized by significant decline platelet count (no less than 10 × 9 /L) within two weeks of SARS-CoV-2 all which recovered 2 weeks. Acute may induce worsen thrombocytopenia but does substantially increase thrombotic events APS. process was related mild titer fluctuation aβ2GP1-IgG, aCL-IgA necessitating careful monitoring management.

Язык: Английский

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An updated immunosenescence exploration in healthy Chinese donors: circular elevated PD-1 on T cell and increased Ki67 on CD8+ T cell towards aging

Aging, Год журнала: 2024, Номер unknown

Опубликована: Июнь 29, 2024

Immunosenescence is a process of immune dysfunction that occurs along with aging. Many studies have focused on the changes different lymphocyte subsets in diseases and However, fluctuation number phenotype subset caused by aging not been comprehensively analyzed, especially effects new indicators such as PD-1 Ki67 peripheral blood rarely reported. We further investigated humoral cellular parameters 150 healthy donors over 18 years old. Age was associated decreased CD4+CD45RA+CD62L+ T cells, CD4+CD45RA+CD31+ increased memory CD4+ or CD8+ dominated male cells. The loss CD28 expression cells transverse trend activated CD38 HLA-DR were also related to age. In addition, men more prominent activation indicators, difference between old young groups obvious. CD4+CD25+CD127- percentage tended decrease age did differ significantly gender. Interestingly, we found positively PD-1+ showed significant age-related variability men. Similarly, CD8+ki-67+ an increasing trend, differences group other elderly males. Our findings can provide immunological clues for future research, offering insights clinical monitoring prevention certain diseases.

Язык: Английский

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The impact of the donors’ COVID-19 status on the outcomes of allogeneic hematopoietic stem cell transplantation: a multi-center retrospective study

Frontiers in Microbiology, Год журнала: 2024, Номер 15

Опубликована: Июль 15, 2024

To explore the impact of donors' COVID-19 status on allogeneic stem cell transplantation (allo-HSCT), we compared transplant outcomes 74 participants. This multi-center retrospective study included nine participants receiving grafts from positive donors (CPD), 45 experienced (CED), and 20 naive (CND). We evaluated engraftment, complications, survival rates among three groups. All apheresis procedures were successful with no significant differences in CD34+ cells or lymphocytes patients achieved engraftment by day 30 post-HSCT. The incidence grade II-IV acute graft-versus-host disease (aGVHD) was 55.6%, 20%, 10% CPD, CED, CND groups, respectively (p = 0.024). Multivariate analysis indicated that positivity at time an independent risk factor for aGVHD 0.020, OR 12.159, 95% CI 1.783 -135.760). No observed groups terms chronic GVHD, viral infection, sinusoidal obstruction syndrome. 6-month overall disease-free also similar Our results suggest COVID-19-positive might not graft collection, short-term allo-HSCT recipients but increase aGVHD. Further research is needed to influence long-term complications recipients.

Язык: Английский

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Immune and inflammation features of severe and critical Omicron infected patients during Omicron wave in China

BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 9, 2024

The current study aimed to investigate the baseline immune and inflammatory features in-hospital outcomes of patients infected with Omicron variant (PIWO) who presented different disease severities during first wave mass infections in Chinese population has occurred.

Язык: Английский

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Hematological Conditions Associated with COVID-19: Pathophysiology, Clinical Manifestations, and Therapeutic Approaches

European Journal of Medical and Health Research, Год журнала: 2024, Номер 2(5), С. 27 - 47

Опубликована: Сен. 1, 2024

This review highlights the significant impact of SARS-CoV-2 on hematological system, revealing complications such as thrombocytopenia, coagulopathy, venous thromboembolism (VTE), and hemolytic anemia, which contribute notably to morbidity mortality, especially in critically ill patients. The underlying mechanisms involve direct viral effects, inflammation, cytokine storms, hypercoagulability. exacerbation pre-existing malignancies common occurrence lymphopenia further illustrate complex interaction between COVID-19 immune system. emphasizes importance early recognition management for clinical practice. It discusses necessity monitoring biomarkers like D-dimer platelet counts, utilizing imaging techniques detecting thromboembolic events, employing timely interventions with anticoagulants immunomodulators. Tailoring treatment individual patient needs involving a multidisciplinary team are essential improving outcomes, particularly also focuses need ongoing research understand precise these complications, explore genetic environmental factors, assess long-term outcomes affected examines emerging variants developing innovative therapeutic approaches, including personalized medicine advanced therapies, address challenges medical

Язык: Английский

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CD151 identifies a NK cell subset that is enriched in COVID-19 patients and correlates with disease severity

Journal of Infection, Год журнала: 2024, Номер 89(6), С. 106304 - 106304

Опубликована: Окт. 5, 2024

Severe coronavirus disease 2019 (COVID-19) often leads to acute respiratory distress syndrome and multi-organ dysfunction, driven by a dysregulated immune response, including cytokine storm with elevated proinflammatory levels. Natural killer (NK) cells are part of the innate system fundamental role in defense against viral infections. However, during COVID-19 infection, they exhibit an altered phenotype impaired functionality contributing immunopathogenesis disease. In this work, we have studied cohort patients (ranging from mild severe) analyzing IL-15, TGF-β, PlGF GDF-15 plasma levels performing multiparametric flow cytometry studies. Our results revealed that severe exhibited high GDF-15, along enrichment NK cell subset expressing CD151 tetraspanin, which correlated IL-15 severity. patients, these CD151+ displayed more activated characterized increased expression HLA-DR, CD38 granzyme B, distinct receptor repertoire, lower CD160 CD31 higher CD55 and, remarkably, tissue-resident markers CD103 decidual marker CD9. Last all, individuals disease, identified expansion

Язык: Английский

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