IgG4 Subclass of Immunoglobulins; Immunobiology and Roles in Relation to Human Diseases DOI Creative Commons
Эва Мала, Moeina Afshari, Jan Krejsek

и другие.

Acta Medica (Hradec Kralove Czech Republic), Год журнала: 2024, Номер 67(4), С. 101 - 106

Опубликована: Янв. 1, 2024

IgG4, a subclass of antibodies known as immunoglobulins have unique structural features, in particular, their Fc regions, that prevents interactions with other receptors on effector cells and thus disabling them activating complements system. IgG4 can undergo process called Fab-arm exchange, wherein they exchange half-molecules antibodies, forming bispecific monovalent antibodies. Isotypic switch mature B germinal centres secondary lymphoid organs is controlled by Tfh subset T cells. Functionally exert immunomodulatory blocking activities, modulating protective inflammation evolved parasitic invasion allergic inflammation. From the pathophysiological point view, autoantibodies are prominently observed autoimmune diseases under umbrella IgG4-autoimmune (IgG4-AID). Furthermore, IgG4-related (IgG4-RD) affecting various characterized lymphoplasmacytic infiltrates storiform fibrosis tissues, together elevated levels blood. A better understanding immunobiology helps us diagnose treat patients suffering from these rare forms diseases.

Язык: Английский

New Facets of Hematolymphoid Eponymic Diseases DOI Open Access

C.S. Ng,

Jilong Qin

Lymphatics, Год журнала: 2025, Номер 3(2), С. 9 - 9

Опубликована: Апрель 9, 2025

Disease eponyms can be confusing, difficult to remember, scientifically non-robust, and lacking in implications on relationships with cell lineage, histogenesis, pathogenesis. This review is geared toward revisiting hematolymphoid diseases light of recent advances technology science by searching the past fifty years literature using Scopus Google Scholar keywords “eponyms, hematolymphoid, diseases, lymphoma, benign, malignant, lymph node, spleen, liver, bone marrow, leukemia”. With technology, there accumulation information morphologic nuances immunologic, immunophenotypic, genetic features various eponymic thus shedding important issues etiology pathogenesis therapy non-neoplastic (Castleman, Evans syndrome Kikuchi–Fujimoto, IgG4-related diseases) neoplastic (Hodgkin, Burkitt, NK/T-cell lymphomas, dendritic/histiocytic neoplasms, Sezary syndrome) diseases. contributes modern nomenclature, classification, subtyping, prognostication, discoveries new treatment strategies

Язык: Английский

Процитировано

0
Immunoglobulin-Related Fibroinflammatory Diseases of Uncertain Etiology—Polarized Isotype Switching Connects an Ancient with a Contemporary Disease DOI Open Access

C.S. Ng

Lymphatics, Год журнала: 2025, Номер 3(2), С. 10 - 10

Опубликована: Апрель 15, 2025

IgG4 is an unusual immunoglobulin (Ig) and the least component of IgG in humans. It often asymmetrical heterobivalent with weak Fc (fragment crystallizable region)-dependent effector function ineffective complement activation, thus playing unclear role immune functions. IgE uncommon Ig, being important mostly allergy type 2 immunity. There are two rare chronic Ig-related fibroinflammatory diseases, namely IgG4-related disease (IgG4RD) Kimura (KD), characterized by prominent IgG4- or IgE-positive plasma cells affected tissues, without blood elevations same Ig. The etiology these diseases unclear, though it appears that pathogenesis both related to polarized Ig heavy chain isotype switching, concomitant other cellular, cytokine chemotaxin interactions culminates characteristic pathologic manifestations inflammation fibrosis. IgG4RD KD, despite having overlapping differing features, may be connected similar pathogenetic switching.

Язык: Английский

Процитировано

0
Successful rituximab treatment in IgG4-related coronary periarteritis: a case-based review DOI
Koji Suzuki, Mitsuhiro Akiyama,

Hiroyuki Fukui

и другие.

Rheumatology International, Год журнала: 2024, Номер 45(1)

Опубликована: Дек. 31, 2024

Язык: Английский

Процитировано

1
IgG4 Subclass of Immunoglobulins; Immunobiology and Roles in Relation to Human Diseases DOI Creative Commons
Эва Мала, Moeina Afshari, Jan Krejsek

и другие.

Acta Medica (Hradec Kralove Czech Republic), Год журнала: 2024, Номер 67(4), С. 101 - 106

Опубликована: Янв. 1, 2024

IgG4, a subclass of antibodies known as immunoglobulins have unique structural features, in particular, their Fc regions, that prevents interactions with other receptors on effector cells and thus disabling them activating complements system. IgG4 can undergo process called Fab-arm exchange, wherein they exchange half-molecules antibodies, forming bispecific monovalent antibodies. Isotypic switch mature B germinal centres secondary lymphoid organs is controlled by Tfh subset T cells. Functionally exert immunomodulatory blocking activities, modulating protective inflammation evolved parasitic invasion allergic inflammation. From the pathophysiological point view, autoantibodies are prominently observed autoimmune diseases under umbrella IgG4-autoimmune (IgG4-AID). Furthermore, IgG4-related (IgG4-RD) affecting various characterized lymphoplasmacytic infiltrates storiform fibrosis tissues, together elevated levels blood. A better understanding immunobiology helps us diagnose treat patients suffering from these rare forms diseases.

Язык: Английский

Процитировано

0