
Cell, Год журнала: 2020, Номер 182(4), С. 1009 - 1026.e29
Опубликована: Июль 29, 2020
Язык: Английский
Cell, Год журнала: 2020, Номер 182(4), С. 1009 - 1026.e29
Опубликована: Июль 29, 2020
Язык: Английский
The Lancet, Год журнала: 2021, Номер 397(10284), С. 1577 - 1590
Опубликована: Март 2, 2021
Язык: Английский
Процитировано
3125Immunity, Год журнала: 2022, Номер 55(1), С. 31 - 55
Опубликована: Янв. 1, 2022
Язык: Английский
Процитировано
1172Cell, Год журнала: 2020, Номер 182(4), С. 976 - 991.e19
Опубликована: Июль 22, 2020
Язык: Английский
Процитировано
717Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Июль 12, 2023
Abstract Studies in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Amyotrophic lateral sclerosis, Huntington’s so on, have suggested that inflammation is not only a result of neurodegeneration but also crucial player this process. Protein aggregates which are very common pathological phenomenon can induce neuroinflammation further aggravates protein aggregation neurodegeneration. Actually, even happens earlier than aggregation. Neuroinflammation induced by genetic variations CNS cells or peripheral immune may deposition some susceptible population. Numerous signaling pathways range been to be involved the pathogenesis neurodegeneration, although they still far from being completely understood. Due limited success traditional treatment methods, blocking enhancing inflammatory considered promising strategies for therapy many them got exciting results animal models clinical trials. Some them, few, approved FDA usage. Here we comprehensively review factors affecting major pathogenicity sclerosis. We summarize current strategies, both clinic, diseases.
Язык: Английский
Процитировано
577Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14
Опубликована: Фев. 16, 2022
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS), and multiple (MS). Microglia can be categorized into two opposite types: classical (M1) or alternative (M2), though there's continuum different intermediate phenotypes between M1 M2, microglia transit from one phenotype to another. release inflammatory mediators induce inflammation neurotoxicity, while M2 anti-inflammatory neuroprotectivity. considered double-edged sword, performing both harmful helpful effects in diseases. Previous studies showed that balancing M1/M2 polarization had promising therapeutic prospect We suggest shifting may significant we focus on the modulation especially by important signal pathways,
Язык: Английский
Процитировано
494Journal of Neuroinflammation, Год журнала: 2021, Номер 18(1)
Опубликована: Ноя. 6, 2021
Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area neuroscience. Initial reports focused on classical immune functions microglia pathological contexts, however, immunological concepts from these studies have been applied to describe neuro-immune interactions the absence disease, injury, or infection. Indeed, terms such 'microglia activation' 'neuroinflammation' used ubiquitously changes disparate contexts; particularly stress research, where prompt undue comparisons conditions. This creates a barrier for investigators new neuro-immunology ultimately hinders our understanding effects microglia. As more seek understand role neurobiology behavior, it is increasingly important develop standard methods study define microglial phenotype function. In this review, we summarize primary research physiological contexts. Further, propose framework better microglia1 chronic stress. approach will enable precise characterization different which should facilitate development microglia-directed therapeutics psychiatric neurological disease.
Язык: Английский
Процитировано
459Nature reviews. Neuroscience, Год журнала: 2019, Номер 21(1), С. 21 - 35
Опубликована: Ноя. 28, 2019
Язык: Английский
Процитировано
451European Journal of Pharmacology, Год журнала: 2020, Номер 887, С. 173554 - 173554
Опубликована: Сен. 14, 2020
Язык: Английский
Процитировано
444Cell, Год журнала: 2020, Номер 181(6), С. 1207 - 1217
Опубликована: Июнь 1, 2020
Язык: Английский
Процитировано
426Neuron, Год журнала: 2018, Номер 100(6), С. 1322 - 1336.e7
Опубликована: Ноя. 1, 2018
Язык: Английский
Процитировано
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