Antioxidants,
Год журнала:
2023,
Номер
12(2), С. 517 - 517
Опубликована: Фев. 18, 2023
Neurodegenerative
disorders
constitute
a
substantial
proportion
of
neurological
diseases
with
significant
public
health
importance.
The
pathophysiology
neurodegenerative
is
characterized
by
complex
interplay
various
general
and
disease-specific
factors
that
lead
to
the
end
point
neuronal
degeneration
loss,
eventual
clinical
manifestations.
Oxidative
stress
result
an
imbalance
between
pro-oxidant
species
antioxidant
systems,
elevation
in
levels
reactive
oxygen
nitrogen
species,
reduction
endogenous
antioxidants.
Recent
studies
have
increasingly
highlighted
oxidative
associated
mitochondrial
dysfunction
be
important
players
pathophysiologic
processes
involved
conditions.
In
this
article,
we
review
current
knowledge
effects
on
central
nervous
system,
different
specific
routes
which
influences
Alzheimer’s
disease,
Parkinson’s
Amyotrophic
Lateral
Sclerosis
Huntington’s
how
may
therapeutically
reversed/mitigated
order
stall
pathological
progression
these
bring
about
benefits.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Июль 12, 2023
Abstract
Studies
in
neurodegenerative
diseases,
including
Alzheimer’s
disease,
Parkinson’s
disease
and
Amyotrophic
lateral
sclerosis,
Huntington’s
so
on,
have
suggested
that
inflammation
is
not
only
a
result
of
neurodegeneration
but
also
crucial
player
this
process.
Protein
aggregates
which
are
very
common
pathological
phenomenon
can
induce
neuroinflammation
further
aggravates
protein
aggregation
neurodegeneration.
Actually,
even
happens
earlier
than
aggregation.
Neuroinflammation
induced
by
genetic
variations
CNS
cells
or
peripheral
immune
may
deposition
some
susceptible
population.
Numerous
signaling
pathways
range
been
to
be
involved
the
pathogenesis
neurodegeneration,
although
they
still
far
from
being
completely
understood.
Due
limited
success
traditional
treatment
methods,
blocking
enhancing
inflammatory
considered
promising
strategies
for
therapy
many
them
got
exciting
results
animal
models
clinical
trials.
Some
them,
few,
approved
FDA
usage.
Here
we
comprehensively
review
factors
affecting
major
pathogenicity
sclerosis.
We
summarize
current
strategies,
both
clinic,
diseases.
Frontiers in Aging Neuroscience,
Год журнала:
2022,
Номер
14
Опубликована: Фев. 16, 2022
Microglia-mediated
neuroinflammation
is
a
common
feature
of
neurodegenerative
diseases
such
as
Alzheimer's
disease
(AD),
Parkinson's
(PD),
amyotrophic
lateral
sclerosis
(ALS),
and
multiple
(MS).
Microglia
can
be
categorized
into
two
opposite
types:
classical
(M1)
or
alternative
(M2),
though
there's
continuum
different
intermediate
phenotypes
between
M1
M2,
microglia
transit
from
one
phenotype
to
another.
release
inflammatory
mediators
induce
inflammation
neurotoxicity,
while
M2
anti-inflammatory
neuroprotectivity.
considered
double-edged
sword,
performing
both
harmful
helpful
effects
in
diseases.
Previous
studies
showed
that
balancing
M1/M2
polarization
had
promising
therapeutic
prospect
We
suggest
shifting
may
significant
we
focus
on
the
modulation
especially
by
important
signal
pathways,
Journal of Neuroinflammation,
Год журнала:
2021,
Номер
18(1)
Опубликована: Ноя. 6, 2021
Microglia
are
emerging
as
critical
regulators
of
neuronal
function
and
behavior
in
nearly
every
area
neuroscience.
Initial
reports
focused
on
classical
immune
functions
microglia
pathological
contexts,
however,
immunological
concepts
from
these
studies
have
been
applied
to
describe
neuro-immune
interactions
the
absence
disease,
injury,
or
infection.
Indeed,
terms
such
'microglia
activation'
'neuroinflammation'
used
ubiquitously
changes
disparate
contexts;
particularly
stress
research,
where
prompt
undue
comparisons
conditions.
This
creates
a
barrier
for
investigators
new
neuro-immunology
ultimately
hinders
our
understanding
effects
microglia.
As
more
seek
understand
role
neurobiology
behavior,
it
is
increasingly
important
develop
standard
methods
study
define
microglial
phenotype
function.
In
this
review,
we
summarize
primary
research
physiological
contexts.
Further,
propose
framework
better
microglia1
chronic
stress.
approach
will
enable
precise
characterization
different
which
should
facilitate
development
microglia-directed
therapeutics
psychiatric
neurological
disease.
