Autophagosome biogenesis comes out of the black box

Nature Cell Biology, Год журнала: 2021, Номер 23(5), С. 450 - 456

Опубликована: Апрель 26, 2021

Язык: Английский

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Lysosomal dysfunction in neurodegeneration: emerging concepts and methods

Trends in Neurosciences, Год журнала: 2022, Номер 45(3), С. 184 - 199

Опубликована: Янв. 13, 2022

Язык: Английский

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Lipid Droplet Contact Sites in Health and Disease

Trends in Cell Biology, Год журнала: 2021, Номер 31(5), С. 345 - 358

Опубликована: Фев. 3, 2021

Язык: Английский

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Mechanisms of nonvesicular lipid transport

The Journal of Cell Biology, Год журнала: 2021, Номер 220(3)

Опубликована: Фев. 19, 2021

We have long known that lipids traffic between cellular membranes via vesicles but only recently appreciated the role of nonvesicular lipid transport. Nonvesicular transport can be high volume, supporting biogenesis rapidly expanding membranes, or more targeted and precise, allowing cells to alter levels specific in membranes. Most such probably occurs at membrane contact sites, where organelles are closely apposed, requires proteins (LTPs), which solubilize shield them from aqueous phase during their Some LTPs cup like shuttle monomers Others form conduits flow This review describes what we know about transfer mechanisms while also identifying many remaining unknowns: How do facilitate movement into require accessory for efficient vivo, how is directionality determined?

Язык: Английский

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Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases

Nature Reviews Molecular Cell Biology, Год журнала: 2023, Номер 24(8), С. 576 - 596

Опубликована: Апрель 27, 2023

Язык: Английский

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