Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(48)
Опубликована: Окт. 6, 2022
Abstract
The
effective
deployment
of
reactive
oxygen
species
(ROS)‐mediated
oncotherapy
in
practice
remains
challenging,
mired
by
uncontrollable
catalytic
processes,
stern
reaction
conditions
and
safety
concerns.
Herein,
we
develop
a
copper
nanodot
integrating
sonodynamic
effects
within
one
active
center,
which
responds
to
exogenous
ultrasound
(US)
endogenous
H
2
O
stimuli.
US
irradiation
induces
the
valence
conversion
from
Cu
II
I
catalyzing
into
⋅OH
for
chemodynamic
therapy.
Meanwhile,
transformation
results
electron‐hole
pairs
separation,
promoting
ROS
generation
Notably,
nanodots
not
only
block
lysosome
fusion
degradation
leading
autophagy
flux
blockage,
but
also
interfere
with
glutathione
peroxidase
4
cystine‐glutamate
antiporter
SLC7A11
function
achieving
ferroptosis.
Furthermore,
reversible
changes,
inherent
hydrophilicity
renal
clearance
ultrasmall
size
guarantee
biosafety.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Ноя. 19, 2021
The
multispanning
membrane
protein
ATG9A
is
a
scramblase
that
flips
phospholipids
between
the
two
leaflets,
thus
contributing
to
expansion
of
phagophore
in
early
stages
autophagy.
Herein,
we
show
depletion
does
not
only
inhibit
autophagy
but
also
increases
size
and/or
number
lipid
droplets
human
cell
lines
and
C.
elegans.
Moreover,
blocks
transfer
fatty
acids
from
mitochondria
and,
consequently,
utilization
mitochondrial
respiration.
localizes
vesicular-tubular
clusters
(VTCs)
are
tightly
associated
with
an
ER
subdomain
enriched
another
scramblase,
TMEM41B,
close
proximity
phagophores,
mitochondria.
These
findings
indicate
plays
critical
role
mobilization
autophagosomes
mitochondria,
highlighting
importance
both
autophagic
non-autophagic
processes.
Journal of Molecular and Cellular Cardiology,
Год журнала:
2021,
Номер
165, С. 1 - 8
Опубликована: Дек. 14, 2021
Autophagy
mediates
cellular
quality
control
mechanisms
and
energy
homeostasis
through
lysosomal
degradation.
is
typically
viewed
as
an
adaptive
process
that
allows
cells
to
survive
against
stress,
such
nutrient
deprivation
hypoxia.
However,
autophagy
also
cell
death
during
development
in
response
stress.
Cell
accompanied
by
activation
accumulation
of
autophagosomes
has
been
classified
type
II
programmed
death.
Compared
the
wealth
knowledge
regarding
role
autophagy,
however,
molecular
which
induces
its
functional
significance
are
poorly
understood.
activated
excessively
under
some
conditions,
causing
uncontrolled
degradation
materials
An
imbalance
between
autophagosome
formation
causes
a
massive
autophagosomes,
subsequently
dysfunction
Dysregulation
unique
form
death,
termed
autosis,
with
defined
morphological
biochemical
features
distinct
from
other
forms
apoptosis
necrosis.
In
heart,
dysregulated
cardiomyocytes
actively
cardiac
injury
including
reperfusion
injury,
doxorubicin
cardiomyopathy,
storage
disorders.
The
goal
this
review
introduce
concept
autophagic
discuss
various
conditions.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(48)
Опубликована: Окт. 6, 2022
Abstract
The
effective
deployment
of
reactive
oxygen
species
(ROS)‐mediated
oncotherapy
in
practice
remains
challenging,
mired
by
uncontrollable
catalytic
processes,
stern
reaction
conditions
and
safety
concerns.
Herein,
we
develop
a
copper
nanodot
integrating
sonodynamic
effects
within
one
active
center,
which
responds
to
exogenous
ultrasound
(US)
endogenous
H
2
O
stimuli.
US
irradiation
induces
the
valence
conversion
from
Cu
II
I
catalyzing
into
⋅OH
for
chemodynamic
therapy.
Meanwhile,
transformation
results
electron‐hole
pairs
separation,
promoting
ROS
generation
Notably,
nanodots
not
only
block
lysosome
fusion
degradation
leading
autophagy
flux
blockage,
but
also
interfere
with
glutathione
peroxidase
4
cystine‐glutamate
antiporter
SLC7A11
function
achieving
ferroptosis.
Furthermore,
reversible
changes,
inherent
hydrophilicity
renal
clearance
ultrasmall
size
guarantee
biosafety.
