MicroRNAs regulating autophagy: opportunities in treating neurodegenerative diseases DOI Creative Commons
Morvarid Mohseni, Ghazal Behzad, Arezoo Farhadi

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Ноя. 8, 2024

Neurodegenerative diseases (NDs) are increasingly prevalent in our aging population, imposing significant social and economic burdens. Currently, most ND patients receive only symptomatic treatment due to limited understanding of their underlying causes. Consequently, there is a pressing need for comprehensive research into the pathological mechanisms NDs by both researchers clinicians. Autophagy, cellular mechanism responsible maintaining equilibrium removing dysfunctional organelles misfolded proteins, plays vital role cell health implicated various diseases. MicroRNAs (miRNAs) exert influence on autophagy hold promise treating these These small oligonucleotides bind 3'-untranslated region (UTR) target mRNAs, leading mRNA silencing, degradation, or translation blockade. This review explores recent findings regulation autophagy-related genes different miRNAs conditions, including neurodegeneration inflammation-related The recognition as key regulators human has spurred investigations pharmacological compounds traditional medicines targeting disease models. catalyzed new wave therapeutic interventions aimed at modulating autophagy.

Язык: Английский

The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson’s disease DOI Creative Commons
Shuanglong Yi, Linfang Wang, Margaret T. Ho

и другие.

Neural Regeneration Research, Год журнала: 2023, Номер 19(5), С. 1150 - 1155

Опубликована: Авг. 14, 2023

Parkinson's disease is a progressive neurodegenerative characterized by motor deficits, dopaminergic neuron loss, and brain accumulation of α-synuclein aggregates called Lewy bodies. Dysfunction in protein degradation pathways, such as autophagy, has been demonstrated neurons critical mechanism for eliminating disease. However, it less well understood how are eliminated glia, the other cell type brain. In present study, we show that autophagy-related gene 9 (Atg9), only transmembrane autophagy machinery, highly expressed Drosophila glia from adult Results immunostaining live imaging analysis reveal portion Atg9 localizes to trans-Golgi network, autophagosomes, lysosomes glia. persistently contact with these organelles. Lacking glial atg9 reduces number omegasomes impairs autophagic substrate degradation. This suggests participates early steps hence control Importantly, loss induces parkinsonian symptoms including neurons, locomotion activation. Our findings identify functional role establish potential link between These results may provide new insights on underlying

Язык: Английский

Процитировано

9

Ceramide regulation of autophagy: A biophysical approach DOI Creative Commons
Yaiza R. Varela, Marina N. Iriondo, Félix M. Goñi

и другие.

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Год журнала: 2023, Номер 1869(2), С. 159444 - 159444

Опубликована: Дек. 4, 2023

Specific membrane lipids play unique roles in (macro)autophagy. Those include phosphatidylethanolamine, to which LC3/GABARAP autophagy proteins become covalently bound the process, or cardiolipin, an important effector mitochondrial (or mitophagy). Ceramide (Cer), N-acyl sphingosine, is one of simplest sphingolipids, known as a stress signal apoptotic pathway. Moreover, Cer increasingly being recognized activator, although its mechanism action unclear. In present review, proposed are summarized, together with some biophysical properties membranes. Possible pathways for activation discussed, including specific protein binding lipid, and Cer-dependent perturbation bilayer properties. generation lateral inhomogeneities (domain formation) given special attention. Recent results, fluorescence atomic force microscopy data, show Cer-promoted enhanced lipid bilayers. These observations could be interpreted terms putative formation Cer-rich nanodomains.

Язык: Английский

Процитировано

9

Omegasomes control formation, expansion, and closure of autophagosomes DOI
Viola Nähse, Harald Stenmark, Kay Oliver Schink

и другие.

BioEssays, Год журнала: 2024, Номер 46(6)

Опубликована: Май 9, 2024

Autophagy, an essential cellular process for maintaining homeostasis and eliminating harmful cytoplasmic objects, involves the de novo formation of double-membraned autophagosomes that engulf degrade debris, protein aggregates, damaged organelles, pathogens. Central to this is phagophore, which forms from donor membranes rich in lipids synthesized at various sites, including endoplasmic reticulum (ER), has emerged as a primary source. The ER-associated omegasomes, characterized by their distinctive omega-shaped structure accumulation phosphatidylinositol 3-phosphate (PI3P), play pivotal role autophagosome formation. Omegasomes are thought serve platforms phagophore assembly recruiting proteins such DFCP1/ZFYVE1 facilitating lipid transfer expand phagophore. Despite critical importance biogenesis, many aspects remain poorly understood, particularly complete range involved omegasome dynamics, detailed mechanisms membrane contact site

Язык: Английский

Процитировано

3

Phospholipid Supply for Autophagosome Biogenesis DOI

Damilola Isola,

Zvulun Elazar

Journal of Molecular Biology, Год журнала: 2024, Номер 436(15), С. 168691 - 168691

Опубликована: Июнь 27, 2024

Язык: Английский

Процитировано

3

MicroRNAs regulating autophagy: opportunities in treating neurodegenerative diseases DOI Creative Commons
Morvarid Mohseni, Ghazal Behzad, Arezoo Farhadi

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Ноя. 8, 2024

Neurodegenerative diseases (NDs) are increasingly prevalent in our aging population, imposing significant social and economic burdens. Currently, most ND patients receive only symptomatic treatment due to limited understanding of their underlying causes. Consequently, there is a pressing need for comprehensive research into the pathological mechanisms NDs by both researchers clinicians. Autophagy, cellular mechanism responsible maintaining equilibrium removing dysfunctional organelles misfolded proteins, plays vital role cell health implicated various diseases. MicroRNAs (miRNAs) exert influence on autophagy hold promise treating these These small oligonucleotides bind 3'-untranslated region (UTR) target mRNAs, leading mRNA silencing, degradation, or translation blockade. This review explores recent findings regulation autophagy-related genes different miRNAs conditions, including neurodegeneration inflammation-related The recognition as key regulators human has spurred investigations pharmacological compounds traditional medicines targeting disease models. catalyzed new wave therapeutic interventions aimed at modulating autophagy.

Язык: Английский

Процитировано

3