Cells, Год журнала: 2024, Номер 13(24), С. 2130 - 2130

Опубликована: Дек. 23, 2024

The nucleus serves as a pivotal regulatory and control hub in the cell, governing numerous aspects of cellular functions, including DNA replication, transcription, RNA processing. Therefore, any deviations nuclear morphology, structure, or organization can strongly affect activities. In this review, we provide an updated perspective on structure function components, focusing linker nucleoskeleton cytoskeleton complex, envelope, lamina, chromatin. Additionally, size should be considered fundamental parameter for state. Its regulation is tightly linked to environmental changes, development, various diseases, cancer. Hence, also concise overview different mechanisms by which determined, emerging role mechanical sensor, implications altered morphology physiology diseased cells.

Язык: Английский