Autophagy, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Canonical autophagy is an intracellular pathway that degrades and recycles cellular components. A key step of this the formation double-membraned organelles, known as autophagosomes, emblematic feature macroautophagy. For convenience, autophagosomes can be categorized into sequential steps, initiation (X), expansion (Y) closure (Z). ATG9A integral membrane protein for its role in X Y steps. whereby it organizes phagophore assembly growth. Here, we report a previously unappreciated function mammalian directing last Z. In particular, partners with ESCRT-III component CHMP2A through IQGAP1 to facilitate autophagosome closure. Thus, orchestrates all stages biogenesis, from This makes unique ATG factor works central hub biogenesis.

Язык: Английский