Impact of SARS-CoV-2 Wuhan and Omicron Variant Proteins on Type I Interferon Response DOI Creative Commons
Marija Janevska,

Evelien Naessens,

Bruno Verhasselt

и другие.

Viruses, Год журнала: 2025, Номер 17(4), С. 569 - 569

Опубликована: Апрель 15, 2025

SARS-CoV-2 has demonstrated a remarkable capacity for immune evasion. While initial studies focused on the Wuhan variant and adaptive immunity, later emerging strains such as Omicron exhibit mutations that may alter their immune-modulatory properties. We performed comprehensive review of evasion mechanisms associated with viral proteins to focus evolutionary dynamics modulation. systematically analyzed compared impact all currently known type I interferon (IFN) responses using dual-luciferase reporter assay carrying an interferon-inducible promoter. Results revealed Nsp1, Nsp5, Nsp14, ORF6 are potent IFN inhibitors conserved across strains. Notably, we identified strain-specific differences, Nsp6 Spike exhibiting enhanced suppression in Omicron, whereas Envelope protein largely retained this function. To extend these findings, investigated selected primary human endothelial cells also observed differences response higher expressing strain variant, suggesting Omicron’s adaptational contribute damped course pandemic’s trajectory.

Язык: Английский

Impact of SARS-CoV-2 Wuhan and Omicron Variant Proteins on Type I Interferon Response DOI Creative Commons
Marija Janevska,

Evelien Naessens,

Bruno Verhasselt

и другие.

Viruses, Год журнала: 2025, Номер 17(4), С. 569 - 569

Опубликована: Апрель 15, 2025

SARS-CoV-2 has demonstrated a remarkable capacity for immune evasion. While initial studies focused on the Wuhan variant and adaptive immunity, later emerging strains such as Omicron exhibit mutations that may alter their immune-modulatory properties. We performed comprehensive review of evasion mechanisms associated with viral proteins to focus evolutionary dynamics modulation. systematically analyzed compared impact all currently known type I interferon (IFN) responses using dual-luciferase reporter assay carrying an interferon-inducible promoter. Results revealed Nsp1, Nsp5, Nsp14, ORF6 are potent IFN inhibitors conserved across strains. Notably, we identified strain-specific differences, Nsp6 Spike exhibiting enhanced suppression in Omicron, whereas Envelope protein largely retained this function. To extend these findings, investigated selected primary human endothelial cells also observed differences response higher expressing strain variant, suggesting Omicron’s adaptational contribute damped course pandemic’s trajectory.

Язык: Английский

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