IGI Global eBooks, Год журнала: 2025, Номер unknown, С. 21 - 70

Опубликована: Июнь 5, 2025

Autophagy and mitophagy are vital for cellular homeostasis, especially in cancer metabolic remodeling, where they play complex roles both tumor suppression promotion. Autophagy, a recycling mechanism, helps cells survive by nutrients generating energy, influencing pathways like glycolysis oxidative phosphorylation, essential proliferation. Mitophagy, the selective degradation of mitochondria, ensures mitochondrial quality, maintaining energy regulating ROS levels, aiding adaptation to hypoxic, nutrient-deprived conditions. The chapter also examines therapeutic potential targeting autophagy cancer. While these processes can contribute resistance against chemotherapy radiotherapy, emerging strategies aim modulate them improved treatment outcomes. Case studies clinical trials offer insights into current therapies, highlighting successes challenges. Ongoing research personalized medicine approaches promising avenues innovative treatments.

Язык: Английский