The Journal of Cell Biology, Год журнала: 2025, Номер 224(7)
Опубликована: Май 13, 2025
The ATG9 transmembrane protein scrambles lipids to regulate phagophore formation during autophagy. Two recent studies from Peng et al. (https://doi.org/10.1083/jcb.202411092) and De Tito (https://doi.org/10.1101/2024.07.23.604321) identify as a conserved regulator of lysosome repair in Caenorhabditis elegans human cells, but differences mechanisms exist between these taxa.
Язык: Английский
Journal of Cellular Physiology, Год журнала: 2025, Номер 240(5)
Опубликована: Май 1, 2025
ABSTRACT Lysosomes are essential organelles degrading a wide range of substrates, maintaining cellular homeostasis, and regulating cell growth through nutrient metabolic signaling. A key vulnerability lysosomes is their membrane permeabilization (LMP), process tightly linked to diseases including aging, neurodegeneration, lysosomal storage disorders, cardiovascular disease. Research progress in the past few years has greatly improved our understanding repair mechanisms. Upon LMP, cells activate multiple remodeling processes restore integrity, such as invagination, tubulation, lipid patching, stabilization. These pathways critical preserving stress tolerance preventing deleterious inflammation death triggered by damage. This review focuses on expanding mechanistic insights repair, highlighting its crucial role health implications for disease pathogenesis therapeutic strategies.
Язык: Английский
Процитировано
0
The Journal of Cell Biology, Год журнала: 2025, Номер 224(7)
Опубликована: Май 13, 2025
The ATG9 transmembrane protein scrambles lipids to regulate phagophore formation during autophagy. Two recent studies from Peng et al. (https://doi.org/10.1083/jcb.202411092) and De Tito (https://doi.org/10.1101/2024.07.23.604321) identify as a conserved regulator of lysosome repair in Caenorhabditis elegans human cells, but differences mechanisms exist between these taxa.
Язык: Английский
Процитировано
0