Journal of Neuroinflammation,
Год журнала:
2020,
Номер
17(1)
Опубликована: Окт. 13, 2020
Alzheimer's
disease
(AD)
is
the
most
common
form
of
dementia,
characterized
by
progressive
degeneration
and
loss
neurons
in
specific
regions
central
nervous
system.
Chronic
activation
immune
cells
resident
brain,
peripheral
cell
trafficking
across
blood-brain
barrier,
release
inflammatory
neurotoxic
factors,
appear
critical
contributors
neuroinflammatory
response
that
drives
progression
neurodegenerative
processes
AD.
As
neuro-immune
network
impaired
course
AD,
this
review
aimed
to
point
out
essential
supportive
role
innate
adaptive
either
normal
brain
as
well
recovery
from
injury.
Since
a
fine-tuning
appears
crucial
ensure
proper
system
functioning,
we
focused
on
TNF
superfamily
member,
TNF-related
apoptosis-inducing
ligand
(TRAIL),
which
modulates
both
pathogenesis
several
immunological
disorders
and,
particular,
AD-related
neuroinflammation.
We
here
summarized
mounting
evidence
potential
involvement
TRAIL
signaling
AD
pathogenesis,
with
aim
provide
clearer
insights
about
novel
therapeutic
approaches
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2022,
Номер
12
Опубликована: Июль 28, 2022
The
persistence
of
latent
reservoir
the
human
immunodeficiency
virus
(HIV)
is
currently
major
challenge
in
curing
HIV
infection.
After
infects
body,
unable
to
be
recognized
by
body’s
immune
system.
Currently,
widely
adopted
antiretroviral
therapy
(ART)
also
unble
eliminate
it,
thus
hindering
progress
treatment.
This
review
discusses
existence
vault
for
treatment,
its
formation
and
factors
affecting
formation,
cell,
tissue
localization,
methods
detection
removing
reservoir,
provide
a
comprehensive
understanding
vault,
order
assist
future
research
play
potential
role
achieving
Glia,
Год журнала:
2023,
Номер
71(9), С. 2071 - 2095
Опубликована: Май 24, 2023
Insights
into
the
role
astrocytes
and
microglia
play
in
normal
diseased
brain
functioning
has
expanded
drastically
over
last
decade.
Recently,
chemogenetic
tools
have
emerged
as
cutting-edge
techniques,
allowing
targeted
spatiotemporal
precise
manipulation
of
a
specific
glial
cell
type.
As
result,
significant
advances
astrocyte
microglial
function
been
made,
showing
how
cells
can
intervene
central
nervous
system
(CNS)
functions
such
cognition,
reward
feeding
behavior
addition
to
their
established
contribution
diseases,
pain,
CNS
inflammation.
Here,
we
discuss
latest
insights
health
disease
that
made
through
application
chemogenetics.
We
will
focus
on
intracellular
signaling
pathways
induced
by
activation
designer
receptors
exclusively
activated
drugs
(DREADDs)
microglia.
also
elaborate
some
potential
pitfalls
translational
DREADD
technology.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июнь 21, 2024
Abstract
Astrocytes
play
a
role
in
healthy
cognitive
function
and
Alzheimer’s
disease
(AD).
The
transcriptional
factor
nuclear
factor-κB
(NF-κB)
drives
astrocyte
diversity,
but
the
mechanisms
are
not
fully
understood.
By
combining
studies
human
brains
animal
models
selectively
manipulating
NF-κB
astrocytes,
we
deepened
understanding
of
astrocytic
brain
health
AD.
In
silico
analysis
bulk
cell-specific
transcriptomic
data
revealed
association
astrocytes
Confocal
validated
higher
level
p50
phosphorylated-p65
glial
fibrillary
acidic
protein
(GFAP)
+
-astrocytes
AD
versus
non-AD
subjects.
mouse
brain,
chronic
activation
disturbed
proteomic
milieu,
causing
loss
mitochondrial-associated
proteins
rise
inflammatory-related
proteins.
Sustained
signaling
also
led
to
microglial
reactivity,
production
pro-inflammatory
mediators,
buildup
senescence-related
p16
INK4A
neurons.
However,
an
model,
inhibition
accelerated
β-amyloid
tau
accumulation.
Molecular
biology
that
increase
GFAP
inflammatory
aquaporin-4,
glymphatic
system
assists
mitigating
Our
investigation
uncovered
fundamental
by
which
enables
astrocytes'
neuroprotective
neurotoxic
responses
brain.
Journal of Neuroinflammation,
Год журнала:
2020,
Номер
17(1)
Опубликована: Окт. 13, 2020
Alzheimer's
disease
(AD)
is
the
most
common
form
of
dementia,
characterized
by
progressive
degeneration
and
loss
neurons
in
specific
regions
central
nervous
system.
Chronic
activation
immune
cells
resident
brain,
peripheral
cell
trafficking
across
blood-brain
barrier,
release
inflammatory
neurotoxic
factors,
appear
critical
contributors
neuroinflammatory
response
that
drives
progression
neurodegenerative
processes
AD.
As
neuro-immune
network
impaired
course
AD,
this
review
aimed
to
point
out
essential
supportive
role
innate
adaptive
either
normal
brain
as
well
recovery
from
injury.
Since
a
fine-tuning
appears
crucial
ensure
proper
system
functioning,
we
focused
on
TNF
superfamily
member,
TNF-related
apoptosis-inducing
ligand
(TRAIL),
which
modulates
both
pathogenesis
several
immunological
disorders
and,
particular,
AD-related
neuroinflammation.
We
here
summarized
mounting
evidence
potential
involvement
TRAIL
signaling
AD
pathogenesis,
with
aim
provide
clearer
insights
about
novel
therapeutic
approaches
