Clinical implications of T cell exhaustion for cancer immunotherapy

Nature Reviews Clinical Oncology, Год журнала: 2022, Номер 19(12), С. 775 - 790

Опубликована: Окт. 10, 2022

Язык: Английский

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Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

Immunity, Год журнала: 2019, Номер 51(6), С. 1043 - 1058.e4

Опубликована: Дек. 1, 2019

Язык: Английский

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Genomic correlates of response to immune checkpoint blockade

Nature Medicine, Год журнала: 2019, Номер 25(3), С. 389 - 402

Опубликована: Март 1, 2019

Язык: Английский

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T cells in health and disease

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Июнь 19, 2023

T cells are crucial for immune functions to maintain health and prevent disease. cell development occurs in a stepwise process the thymus mainly generates CD4

Язык: Английский

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Precursor exhausted T cells: key to successful immunotherapy?

Nature reviews. Immunology, Год журнала: 2019, Номер 20(2), С. 128 - 136

Опубликована: Окт. 7, 2019

Язык: Английский

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CD8+ T Cell Exhaustion in Cancer

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Июль 20, 2021

A paradigm shift in the understanding of exhausted CD8 + T cell (T ex ) lineage is underway. Originally thought to be a uniform population that progressively loses effector function response persistent antigen, single-cell analysis has now revealed composed multiple interconnected subpopulations. The heterogeneity within comprised immune checkpoint blockade (ICB) permissive and refractory subsets termed stem-like terminally differentiated cells, respectively. These populations occupy distinct peripheral intratumoral niches are characterized by transcriptional processes govern transitions between states. This review presents key findings field construct an updated view spatial, transcriptional, functional anti-tumoral . emerging insights broadly call for (re-)focusing cancer immunotherapies center on driver mechanism(s) underlying developmental continuum aimed at stabilizing subsets.

Язык: Английский

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

European Journal of Immunology, Год журнала: 2021, Номер 51(12), С. 2708 - 3145

Опубликована: Дек. 1, 2021

Abstract The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes functional assays all major human murine immune cell subsets. Notably, contain helpful tables highlighting differences between cells. Another useful feature this is analysis clinical samples with examples applications in context autoimmune diseases, cancers as well acute chronic infectious diseases. Furthermore, there are detailing tips, tricks pitfalls avoid. All written peer‐reviewed by leading experts immunologists, making an essential state‐of‐the‐art handbook for basic researchers.

Язык: Английский

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Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

Cell, Год журнала: 2021, Номер 184(25), С. 6101 - 6118.e13

Опубликована: Ноя. 30, 2021

Язык: Английский

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Metabolic and epigenetic regulation of T-cell exhaustion

Nature Metabolism, Год журнала: 2020, Номер 2(10), С. 1001 - 1012

Опубликована: Сен. 21, 2020

Язык: Английский

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Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer

Nature Cancer, Год журнала: 2021, Номер 3(1), С. 108 - 121

Опубликована: Дек. 23, 2021

Abstract Anti-PD-1 treatment has shown unprecedented clinical success in the of non-small-cell lung cancer (NSCLC), but underlying mechanisms remain incompletely understood. Here, we performed temporal single-cell RNA and paired T-cell receptor sequencing on 47 tumor biopsies from 36 patients with NSCLC following PD-1-based therapies. We observed increased levels precursor exhausted T (Texp) cells responsive tumors after treatment, characterized by low expression coinhibitory molecules high GZMK . By contrast, nonresponsive failed to accumulate Texp cells. Our data suggested that were unlikely be derived reinvigoration terminally cells; instead, they accumulated (1) local expansion (2) replenishment peripheral both new pre-existing clonotypes, a phenomenon named clonal revival. study provides insights into therapies, implicating revival as steps improve treatment.

Язык: Английский

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