The intersection of influenza infection and autoimmunity

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 3, 2025

The relationship between viral infection and autoimmune manifestations has been emerging as a significant focus of study, underscoring the intricate interplay infections immune system. Influenza can result in spectrum clinical outcomes, ranging from mild illness to severe disease, including mortality. Annual influenza vaccination remains most effective strategy for preventing its associated complications. complications arising acute are attributable not only direct effects but also dysregulated response it elicits. Notably, associations various diseases, such Guillain-Barré Syndrome (GBS), Type 1 Diabetes (T1D), antiphospholipid syndrome, have reported. While long recognized potential triggers autoimmunity, underlying mechanisms remain be elucidated. Here, we described pathophysiology caused by influenza-associated manifestations. Current advances on understanding that lead strategies were summarized.

Язык: Английский

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Inborn Errors of Nucleic Acid Sensing and Type I Interferon Signaling Determine Viral Susceptibility in Humans

European Journal of Immunology, Год журнала: 2025, Номер 55(5)

Опубликована: Май 1, 2025

The innate immune system relies on nucleic acid (NA) sensors to detect viral infections and trigger type I interferon (IFN-I) responses, which are crucial for antiviral defense. NA pattern recognition receptors RNA or DNA within various cellular compartments, initiating signaling pathways. However, inherited deficiencies in these sensing mechanisms can result increased susceptibility severe infections. This review explores key genetic mutations affecting IFN-I pathways that predispose individuals life-threatening diseases, including herpesviruses, respiratory viruses, enteroviruses, arboviruses, vaccine-strain disseminated diseases. identification of monogenic defects afflicted by infections, along with the observed incomplete penetrance mutations, highlight intricate interplay host's intrinsic, innate, adaptive response invading pathogens. These insights into molecular basis immunity not only underscore clinical challenges associated but also offers opportunity personalized treatment strategies, screening, tailored vaccination protocols, targeted therapies.

Язык: Английский

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Type I Interferon Autoantibodies Correlate With Cellular Immune Alterations in Severe COVID-19

The Journal of Infectious Diseases, Год журнала: 2024, Номер 230(2), С. e318 - e326

Опубликована: Фев. 29, 2024

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to disease increased morbidity and mortality among certain risk groups. The presence of autoantibodies against type I interferons (aIFN-Abs) is one mechanism that contributes 2019 (COVID-19).

Язык: Английский

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Characterization of proteogenomic signatures of differentiation of CD4+ T cell subsets

DNA Research, Год журнала: 2022, Номер 30(1)

Опубликована: Дек. 28, 2022

Functionally distinct CD4+ helper T (Th) cell subsets, including Th1, Th2, Th17, and regulatory cells (Treg), play a pivotal role in the regulation of acquired immunity. Although key proteins involved Th differentiation have already been identified how proteogenomic landscape changes during activation remains unclear. To address this issue, we characterized signatures to each subsets by RNA sequencing liquid chromatography-assisted mass spectrometry, which enabled us simultaneously quantify more than 10,000 protein-coding transcripts 8,000 single-shot. The results indicated that receptor affected almost half transcript protein levels low correlative gene-specific manner, specific cytokine treatments modified profiles manner subsets: Th17 Tregs particularly exhibited unique compared other subsets. Interestingly, in-depth proteome data revealed mRNA alone were not enough delineate functional activation, suggesting dataset obtained study serves as indispensable resource for understanding comprehensive molecular mechanisms underlying effector differentiation.

Язык: Английский

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Gene-environment interactions that influence CVD, lipid traits, obesity, diabetes, and hypertension appear to be able to influence gene therapy

Molecular Aspects of Medicine, Год журнала: 2023, Номер 94, С. 101213 - 101213

Опубликована: Сен. 11, 2023

Язык: Английский

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