Microbiota–gut–brain axis: interplay between microbiota, barrier function and lymphatic system
Gut Microbes,
Год журнала:
2024,
Номер
16(1)
Опубликована: Авг. 25, 2024
The
human
gastrointestinal
tract,
boasting
the
most
diverse
microbial
community,
harbors
approximately
100
trillion
microorganisms
comprising
viruses,
bacteria,
fungi,
and
archaea.
profound
genetic
metabolic
capabilities
of
gut
microbiome
underlie
its
involvement
in
nearly
every
facet
biology,
from
health
maintenance
development
to
aging
disease.
Recent
recognition
microbiota
–
brain
axis,
referring
bidirectional
communication
network
between
microbes
their
host,
has
led
a
surge
interdisciplinary
research.
This
review
begins
with
an
overview
current
understandings
regarding
influence
on
intestinal
blood-brain
barrier
integrity.
Subsequently,
we
discuss
mechanisms
examining
role
microbiota-related
neural
transmission,
metabolites,
hormones
immunity.
We
propose
concept
microbiota-mediated
multi-barrier
modulation
potential
treatment
neurological
disorders.
Furthermore,
lymphatic
function
is
discussed,
providing
insights
into
lesser-known
conduits
ecosystem
within
brain.
In
final
section,
conclude
by
describing
ongoing
frontiers
understanding
axis's
impact
Язык: Английский
Aging-induced changes in lymphatic muscle cell transcriptomes are associated with reduced pumping of peripheral collecting lymphatic vessels in mice
Developmental Cell,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Meningeal lymphatic drainage: novel insights into central nervous system disease
Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Май 4, 2025
Abstract
In
recent
years,
increasing
evidence
has
suggested
that
meningeal
lymphatic
drainage
plays
a
significant
role
in
central
nervous
system
(CNS)
diseases.
Studies
have
indicated
CNS
diseases
and
conditions
associated
with
dysfunction
include
neurodegenerative
diseases,
stroke,
infections,
traumatic
brain
injury,
tumors,
functional
cranial
disorders,
hydrocephalus.
However,
the
understanding
of
regulatory
damage
mechanisms
lymphatics
under
physiological
pathological
is
currently
limited.
Given
importance
profound
interplay
between
this
review
covers
seven
key
aspects:
development
structure
vessels,
methods
for
observing
lymphatics,
function
molecular
relationships
vessels
potential
conclusions
outstanding
questions.
We
will
explore
relationship
development,
structure,
current
both
animal
models
humans,
identify
unresolved
points
research.
The
aim
to
provide
new
directions
future
research
therapeutic
strategies
targeting
by
critically
analyzing
advancements
field,
identifying
gaps
knowledge,
proposing
innovative
approaches
address
these
gaps.
Язык: Английский