“What’s in a name?” Clarifying the identity of RORγt+ antigen-presenting cells

The Journal of Experimental Medicine, Год журнала: 2025, Номер 222(8)

Опубликована: Май 15, 2025

Recent publications have demonstrated that antigen-presenting cells (APCs) targeted by Rorc-cre (also known as RORγt-cre) are required for the induction of peripheral regulatory T (pTreg) in response to commensal and dietary antigens. In this issue JEM, Sun et al. (https://doi.org/10.1084/jem.20250573) provide key insights into identity these cells, revealing Rorc-cre–traced APCs include group 3 innate lymphoid (ILC3s), dendritic (DCs), extrathymic AIRE-expressing (eTACs). Their work highlights eTACs critical inducing RORγt+ pTregs specific food antigens, while implicating DCs generation RORγt− pTregs.

Язык: Английский

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Thetis cells: regulators of intestinal immune tolerance

Current Opinion in Immunology, Год журнала: 2025, Номер 95, С. 102570 - 102570

Опубликована: Май 26, 2025

Язык: Английский

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RORγt+ antigen-presenting cells mediate food tolerance

Nature reviews. Immunology, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Язык: Английский

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