Reviewer #2 (Public Review): A computational model predicts sex-specific responses to calcium channel blockers in mesenteric vascular smooth muscle

Опубликована: Сен. 12, 2023

The function of the smooth muscle cells lining walls systemic arteries and arterioles is to regulate diameter vessels control blood flow pressure. Here, we describe an in silico model, which call “Hernandez-Hernandez model”, electrical Ca2+ signaling arterial myocytes based on new experimental data indicating sex-specific differences male female from resistance arteries. model suggests fundamental ionic mechanisms underlying membrane potential intracellular during development myogenic tone vessels. Although suggest that KV1.5 channel currents have similar amplitudes, kinetics, voltage dependencies myocytes, simulations current dominant regulating myocytes. In cells, larger KV2.1 expression longer time constants for activation than predictions simulated plays a primary role potential. Over physiological range potentials, gating small number voltage-gated K+ channels L-type are predicted drive excitability. We also show idealized computational vessel, exhibits heightened sensitivity commonly used blockers compared male. summary, present framework investigate impact anti-hypertensive drugs.

Язык: Английский

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A computational model predicts sex-specific responses to calcium channel blockers in mesenteric vascular smooth muscle

Опубликована: Сен. 12, 2023

The function of the smooth muscle cells lining walls systemic arteries and arterioles is to regulate diameter vessels control blood flow pressure. Here, we describe an in silico model, which call “Hernandez-Hernandez model”, electrical Ca 2+ signaling arterial myocytes based on new experimental data indicating sex-specific differences male female from resistance arteries. model suggests fundamental ionic mechanisms underlying membrane potential intracellular during development myogenic tone vessels. Although suggest that K V 1.5 channel currents have similar amplitudes, kinetics, voltage dependencies myocytes, simulations current dominant regulating myocytes. In cells, larger 2.1 expression longer time constants for activation than predictions simulated plays a primary role potential. Over physiological range potentials, gating small number voltage-gated + channels L-type are predicted drive excitability. We also show idealized computational vessel, exhibits heightened sensitivity commonly used blockers compared male. summary, present framework investigate impact anti-hypertensive drugs.

Язык: Английский

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A computational model predicts sex-specific responses to calcium channel blockers in mesenteric vascular smooth muscle

Опубликована: Дек. 20, 2023

The function of the smooth muscle cells lining walls systemic arteries and arterioles is to regulate diameter vessels control blood flow pressure. Here, we describe an in-silico model, which call “Hernandez-Hernandez model”, electrical Ca 2+ signaling in arterial myocytes based on new experimental data indicating sex-specific differences male female from resistance arteries. model suggests fundamental ionic mechanisms underlying membrane potential intracellular during development myogenic tone vessels. Although suggest that K V 1.5 channel currents have similar amplitudes, kinetics, voltage dependencies myocytes, simulations current dominant regulating myocytes. In cells, larger 2.1 expression longer time constants for activation than predictions simulated plays a primary role potential. Over physiological range potentials, gating small number voltage-gated + channels L-type are predicted drive excitability. We also show idealized computational vessel, exhibits heightened sensitivity commonly used blockers compared male. summary, present framework investigate impact anti-hypertensive drugs.

Язык: Английский

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Reviewer #2 (Public Review): A computational model predicts sex-specific responses to calcium channel blockers in mesenteric vascular smooth muscle

Опубликована: Дек. 20, 2023

The function of the smooth muscle cells lining walls systemic arteries and arterioles is to regulate diameter vessels control blood flow pressure. Here, we describe an in-silico model, which call "Hernandez-Hernandez model", electrical Ca2+ signaling in arterial myocytes based on new experimental data indicating sex-specific differences male female from resistance arteries. model suggests fundamental ionic mechanisms underlying membrane potential intracellular during development myogenic tone vessels. Although suggest that KV1.5 channel currents have similar amplitudes, kinetics, voltage dependencies myocytes, simulations current dominant regulating myocytes. In cells, larger KV2.1 expression longer time constants for activation than predictions simulated plays a primary role potential. Over physiological range potentials, gating small number voltage-gated K+ channels L-type are predicted drive excitability. We also show idealized computational vessel, exhibits heightened sensitivity commonly used blockers compared male. summary, present framework investigate impact anti-hypertensive drugs.

Язык: Английский

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Author Response: A computational model predicts sex-specific responses to calcium channel blockers in mesenteric vascular smooth muscle

Опубликована: Дек. 20, 2023

The function of the smooth muscle cells lining walls systemic arteries and arterioles is to regulate diameter vessels control blood flow pressure. Here, we describe an in-silico model, which call "Hernandez-Hernandez model", electrical Ca2+ signaling in arterial myocytes based on new experimental data indicating sex-specific differences male female from resistance arteries. model suggests fundamental ionic mechanisms underlying membrane potential intracellular during development myogenic tone vessels. Although suggest that KV1.5 channel currents have similar amplitudes, kinetics, voltage dependencies myocytes, simulations current dominant regulating myocytes. In cells, larger KV2.1 expression longer time constants for activation than predictions simulated plays a primary role potential. Over physiological range potentials, gating small number voltage-gated K+ channels L-type are predicted drive excitability. We also show idealized computational vessel, exhibits heightened sensitivity commonly used blockers compared male. summary, present framework investigate impact anti-hypertensive drugs.

Язык: Английский

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