Macromolecular condensation is unlikely to buffer intracellular osmolality

Опубликована: Фев. 13, 2025

The flux of water across biological membrane is determined by gradients in transmembrane osmolality and the permeability membranes. Watson et al. (2023) have proposed that reversible formation disassembly molecular condensates could act as primary buffer cytoplasmic face changes extracellular osmolality. In this communication, we show using well-established biophysics, plasma membranes likely to overwhelm any buffers.

Язык: Английский

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Macromolecular condensation is unlikely to buffer intracellular osmolality

Опубликована: Март 14, 2025

The flux of water across biological membrane is determined by gradients in transmembrane osmolality and the permeability membranes. Watson et al. (2023) have proposed that reversible formation disassembly molecular condensates could act as primary buffer cytoplasmic face changes extracellular osmolality. In this communication, we show using well-established biophysics, plasma membranes likely to overwhelm any buffers.

Язык: Английский

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Macromolecular condensation is unlikely to buffer intracellular osmolality

Опубликована: Фев. 14, 2025

Watson et al. (2023, Macromolecular condensation buffers intracellular water potential, Nature 623: 842-852) have proposed that the reversible formation and disassembly of molecular condensates could act as primary buffer cytoplasmic osmolality in face changes extracellular osmolality. In this communication, we show using well-established membrane biophysics, permeability plasma membranes is likely to overwhelm any buffers.

Язык: Английский

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