Radioiodine Exhalation Following Oral I-131 Administration in a Mouse Model
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 897 - 897
Опубликована: Апрель 8, 2025
Background:
The
exhalation
of
radioiodine
following
therapy
(RIT)
presents
a
challenge
in
radiation
protection,
though
the
mechanisms
remain
incompletely
understood.
Previous
studies
have
indicated
that
is
predominantly
exhaled
an
organically
bound
form
humans.
Methods:
This
study
investigates
chemical
composition
and
amounts
radioiodine,
as
well
impact
thyroid-targeted
pharmacological
interventions,
using
controlled
mouse
model.
Female
Balb/c
mice
(25
g)
were
administered
oral
doses
(0.1,
1,
2,
10,
23
MBq
per
animal)
with
without
prior
treatment
thyroid-blocking
agents
(stable
iodine,
perchlorate)
or
antithyroid
drugs
(carbimazole).
Exhaled
was
collected
metabolic
cages,
separating
forms
(aerosolized
elemental
iodine),
quantified
via
scintillation
counter.
Results:
activity
proportional
to
dose
(0.2–0.3%).
Thyroid-blocking
increased
exhalation,
shifting
toward
iodine.
Antithyroid
reduced
but
aerosol
formation,
particularly
at
higher
I-131
doses.
Organically
iodine
remained
predominant
species
all
groups.
Conclusions:
These
results
highlight
critical
role
thyroid
organification.
blockade
uptake
disrupted
formation
suggesting
organification
requires
passage
through
thyroid.
Additionally,
support
hypothesis
metabolism
outside
less
efficient,
contributing
organic
species.
Radical
likely
key
factor
generating
these
volatile
species,
radiation-induced
methyl
radicals
playing
their
formation.
Язык: Английский
Monte Carlo damage models of different complexity levels predict similar trends in radiation induced DNA damage
Physics in Medicine and Biology,
Год журнала:
2024,
Номер
69(21), С. 215035 - 215035
Опубликована: Окт. 18, 2024
Ion
therapies
have
an
increased
relative
biological
effectiveness
(RBE)
compared
to
X-rays,
but
this
remains
poorly
quantified
across
different
radiation
qualities.
Mechanistic
models
that
simulate
DNA
damage
and
repair
after
irradiation
could
be
used
help
better
quantify
RBE.
However,
there
is
large
variation
in
model
design
with
the
simulation
detail
number
of
parameters
required
accurately
predict
key
endpoints
remaining
unclear.
This
work
investigated
varying
determine
how
features
impact
predicted
damage.
Methods:
Damage
reducing
were
designed
TOPAS-nBio
Medras
investigating
inclusion
chemistry,
realistic
nuclear
geometries,
single
strand
break
damage,
track
structure.
The
nucleus
irradiated
1
Gy
protons
a
range
linear
energy
transfers
(LETs).
reduced
levels
fit
proton
double
(DSB)
yield
by
most
detailed
model.
Irradiation
optimised
qualities
was
then
simulated,
before
undergoing
response
model.
Results:
Simplified
exposures
similar
trends
On
average
qualities,
simplified
experienced
8%
larger
28%
chromosome
aberrations.
Aberration
differences
became
more
prominent
at
higher
LETs,
having
increasing
on
distribution
therefore
misrepair
DSBs.
overall
remained
agreement
likely
achievable
through
optimisation.
Conclusion:
Several
simplifications
made
without
compromising
predictions,
although
changes
complexity
observed.
suggests
simpler,
efficient
may
sufficient
for
initial
comparisons,
if
validated
against
experimental
data.
.
Язык: Английский
The clinical potential of mechanistic models of individualized radiosensitivity
Expert Review of Anticancer Therapy,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 19, 2024
Keywords:
RadiotherapyIntrinsic
RadiosensitivityMechanistic
ModellingRadiobiologyPersonalised
radiotherapy
Язык: Английский