Spatial structure facilitates evolutionary rescue by drug resistance

PLoS Computational Biology, Год журнала: 2025, Номер 21(4), С. e1012861 - e1012861

Опубликована: Апрель 3, 2025

Bacterial populations often have complex spatial structures, which can impact their evolution. Here, we study how structure affects the evolution of antibiotic resistance in a bacterial population. We consider minimal model spatially structured where all demes (i.e., subpopulations) are identical and connected to each other by migration rates. show that facilitate survival population treatment, starting from sensitive inoculum. Specifically, be rescued if resistant mutants appear present when drug is added, fate these probability they present. Indeed, fixation neutral or deleterious mutations providing increased smaller populations. This promotes local population, facilitates evolutionary rescue rare mutation regime. Once resistance, migrations allow spread demes. Our main result extends more case there

Язык: Английский

Spatial structure facilitates evolutionary rescue by cost-free drug resistance

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

Abstract Bacterial populations often have complex spatial structures, which can impact their evolution. Here, we study how structure affects the evolution of antibiotic resistance in a bacterial population. We consider minimal model spatially structured where all demes (i.e., subpopulations) are identical and connected to each other by migration rates. show that facilitate survival population treatment, starting from sensitive inoculum. Indeed, be rescued if resistant mutants appear present when drug is added, fate these probability they present. Specifically, mutation provides neutral or effectively neutral, its fixation increased smaller populations. This promotes local population, facilitates evolutionary rescue cost-free resistance. Once resistance, migrations allow spread demes. Our main results extend case there inoculum, more structures. They also carry fitness cost, although timescales involved longer. Author Summary Antibiotic major challenge, since bacteria tend adapt drugs subjected to. Understanding what conditions hinder appearance thus strong interest. Most natural microbial includes host-associated microbiota, such as gut microbiota. promoting presence bacteria. giving take over small easily than large ones, thanks importance fluctuations Resistant then whole Thus, source treatment failure. effect generic does not require environment heterogeneity.

Язык: Английский

Slow spatial migration can help eradicate cooperative antimicrobial resistance in time-varying environments

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

Abstract Antimicrobial resistance (AMR) is a global threat and combating its spread of paramount importance. AMR often results from cooperative behaviour with shared protection against drugs. Microbial communities generally evolve in volatile environments spatial structures. Migration, fluctuations, environmental variability thus have significant impacts on AMR, whose maintenance static promoted by migration. Here, we demonstrate that this picture changes dramatically time-fluctuating spatially structured environments. To end, consider two-dimensional metapopulation model consisting demes which drug-resistant sensitive cells time-changing environment the presence toxin can be shared. Cells migrate between neighbouring hence connect them. When varies neither too quickly nor slowly, dynamics characterised bottlenecks causing fluctuation-driven local extinctions, mechanism countered migration rescues AMR. Through simulations mathematical analysis, investigate how influence probability eradication. We determine near-optimal conditions for eradication, show slow but nonzero speeds up clearance enhance eradication probability. discuss our study’s impact laboratory-controlled experiments.

Язык: Английский