iScience, Год журнала: 2024, Номер 27(12), С. 111321 - 111321
Опубликована: Ноя. 5, 2024
Язык: Английский
Micromachines, Год журнала: 2023, Номер 15(1), С. 70 - 70
Опубликована: Дек. 29, 2023
Implantable electrodes are crucial for stimulation safety and recording quality of neuronal activity. To enhance their electrochemical performance, electrodeposited nanostructured platinum (nanoPt) iridium oxide (IrOx) have been proposed due to advantages in situ deposition ease processing. However, unstable adhesion has a challenge practical applications. This study investigated the performance stability nanoPt IrOx coatings on hierarchical platinum-iridium (Pt-Ir) substrates prepared by femtosecond laser, compared with smooth Pt-Ir substrates. Ultrasonic testing, agarose gel cyclic voltammetry (CV) testing were used evaluate coatings’ stability. Results showed that substrate significantly enhanced charge-storage capacity both more than 330 mC/cm2, which was over 75 times electrode. The could also reduce cracking after ultrasonic, CV testing. Although some shedding observed coating one hour sonication, it good tests. Stable may not only improve but benefit function neurobiochemical detection.
Язык: Английский
Процитировано
6
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
. Intracortical microstimulation can be an effective method for restoring sensory perception in contemporary brain-machine interfaces. However, the mechanisms underlying better control of neuronal responses remain poorly understood, as well relationship between activity and other concomitant phenomena occurring around stimulation site.
Язык: Английский
Процитировано
2
APL Bioengineering, Год журнала: 2024, Номер 8(2)
Опубликована: Июнь 1, 2024
Electrical stimulation of the visual nervous system could improve quality life patients affected by acquired blindness restoring some sensations, but requires careful optimization parameters to produce useful perceptions. Neural correlates elicited perceptions be used for fast automatic optimization, with electroencephalography as a natural choice it can non-invasively. Nonetheless, its low signal-to-noise ratio may hinder discrimination similar patterns, preventing use in electrical stimulation. Our work investigates first time discriminability electroencephalographic responses stimuli compatible stimulation, employing newly dataset whose encompass concurrent variation several features, while neuroscience research tends study neural single features. We then performed above-chance single-trial decoding multiple features our crafted using relatively simple machine learning algorithms. A scheme information from stimulus presentations was implemented, substantially improving performance, suggesting that such methods should systematically future applications. The significance present relies determination which decoded stimulation-compatible and at granularity they discriminated. pave way optimize parameters, thus increasing effectiveness current neuroprostheses.
Язык: Английский
Процитировано
2
Frontiers in Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Июнь 19, 2024
Vision plays a major role in perceiving external stimuli and information our daily lives. The neural mechanism of color vision is complicated, involving the co-ordinated functions variety cells, such as retinal cells lateral geniculate nucleus well multiple levels visual cortex. In this work, we reviewed history experimental theoretical studies on issue, from fundamental individual system to coding transmission signals sophisticated brain processes at different levels. We discuss various hypotheses, models, theories related present some suggestions for developing novel implanted devices that may help restore visually impaired people or introduce artificial those who need it.
Язык: Английский
Процитировано
2
Scientific Reports, Год журнала: 2023, Номер 13(1)
Опубликована: Апрель 28, 2023
Abstract Shape-morphable electrode arrays can form 3D surfaces to conform complex neural anatomy and provide consistent positioning needed for next-generation interfaces. Retinal prostheses need a curved interface match the spherical eye coverage of several cm restore peripheral vision. We fabricated full-field array that (1) cover visual field 57° based on position 113° substrate size; (2) fold compact shape implantation; (3) self-deploy into curvature fitting after implantation. The consists multiple polymer layers, specifically, sandwich structure elastomer/polyimide-based-electrode/elastomer, coated one side with hydrogel. Electrodeposition high-surface-area platinum/iridium alloy significantly improved electrical properties electrodes. Hydrogel over-coating reduced performance, but electrodes retained better than those without platinum/iridium. was rolled and, once implanted ex vivo pig eyes, restored surface. retinal provides significant retina while allowing surgical implantation through an incision 33% final device diameter. shape-changing material platform be used other interfaces require conformability neuroanatomy.
Язык: Английский
Процитировано
5
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Янв. 27, 2024
Abstract A fundamental challenge in neuroengineering is determining a proper artificial input to sensory system that yields the desired perception. In neuroprosthetics, this process known as encoding, and it holds crucial role prosthetic devices restoring perception individuals with disabilities. For example, visual prostheses, one key aspect of image encoding downsample images captured by camera size matching number inputs resolution prosthesis. Here, we show downsampling an using inherent computation retinal network better performance compared learning-free methods. We have validated learning-based approach (actor-model framework) exploits signal transformation from photoreceptors ganglion cells measured explanted mouse retinas. The actor-model framework generates downsampled eliciting neuronal response in-silico ex-vivo higher reliability than produced approach. During learning process, actor learns optimize contrast kernel’s weights. This methodological might guide future strategies for prostheses. Ultimately, could be applicable other prostheses such cochlear or limb.
Язык: Английский
Процитировано
1
Artificial Organs, Год журнала: 2024, Номер 48(11), С. 1223 - 1250
Опубликована: Июль 18, 2024
Retinal prostheses offer hope for individuals with degenerative retinal diseases by stimulating the remaining cells to partially restore their vision. This review delves into current advancements in prosthesis technology, a special emphasis on pivotal role that image processing and machine learning techniques play this evolution.
Язык: Английский
Процитировано
1
Advanced Engineering Materials, Год журнала: 2023, Номер 25(9)
Опубликована: Янв. 27, 2023
Neurotechnology applies methods and devices to mitigate the burden of neurological mental disorders. In particular, neural interfaces establish a long‐term, seamless, symbiotic integration between implants tissue. Materials play pivotal role in neurotechnology. Advanced materials engineering are crucial achieving desired function outcome. Recently, extended their range applications with emergence flexible, conformable, stretchable, injectable, transient electronics. However, despite this enormous advancement science engineering, clinical still rely on old‐fashioned but reliable processes. The gap research development industry adoption has recently gained high interest. This article analyzes recent developments, discusses roadblocks, provides roadmap for applied
Язык: Английский
Процитировано
3
BMC Biomedical Engineering, Год журнала: 2023, Номер 5(1)
Опубликована: Июль 2, 2023
Assistive technology (AT) development worldwide aims to enhance the quality of life for persons with disabilities and elderly, yet its commercialization may face challenges. This collection at obtaining a better understanding hurdles that various stakeholders in successful AT.
Язык: Английский
Процитировано
1
ESSCIRC 2022- IEEE 48th European Solid State Circuits Conference (ESSCIRC), Год журнала: 2023, Номер unknown, С. 301 - 304
Опубликована: Сен. 11, 2023
Blindness affects millions of people around the world, being triggered by various defects within human visual system. Different kinds prostheses have been developed, which can stimulate retina, optical nerve or even cortex, creating a basic form vision. Here, we present scalable ASIC and data-acquisition system that enables neural stimulation recording in cortex. The includes 128 area-efficient fully-programmable stimulators 64 low-noise artifact-tolerant channels. chip has implemented 55nm CMOS technology, our measurement results demonstrate its ability to record simultaneously from same electrode neighboring electrodes, is important enable implementation cortex prostheses.
Язык: Английский
Процитировано
1