Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Nature Reviews Molecular Cell Biology, Год журнала: 2022, Номер 23(7), С. 499 - 515

Опубликована: Фев. 21, 2022

Язык: Английский

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Oxidative Stress and Antioxidant Metabolism under Adverse Environmental Conditions: a Review

The Botanical Review, Год журнала: 2020, Номер 87(4), С. 421 - 466

Опубликована: Дек. 1, 2020

Язык: Английский

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Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

Physiological Reviews, Год журнала: 2022, Номер 103(1), С. 31 - 276

Опубликована: Апрель 18, 2022

Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous regulator of a broad range physiological functions. H2S belongs to class molecules known gasotransmitters, which typically include nitric oxide (NO) and carbon monoxide (CO). Three enzymes are recognized sources in various cells tissues: cystathionine γ-lyase (CSE), β-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3-MST). The present article reviews regulation these well pathways their enzymatic nonenzymatic degradation elimination. multiple interactions with other labile (e.g., NO) reactive oxygen species also outlined. Next, biological targets signaling outlined, special reference or oxidative posttranscriptional modification (persulfidation sulfhydration) proteins effect on channels intracellular second messenger pathways, gene transcription translation, cellular bioenergetics metabolism. pharmacological molecular tools currently available study physiology reviewed, including utility limitations. In subsequent sections, role functions is membrane potential, endo- exocytosis, cell organelles (endoplasmic reticulum, Golgi, mitochondria), movement, cycle, differentiation, aspects regulated death. roles types organ systems overviewed, red blood cells, immune central peripheral nervous (with focus neuronal transmission, learning, memory formation), vascular function (including angiogenesis its specialized cerebrovascular, renal, pulmonary beds) senses, vision, hearing, taste smell, pain-sensing. Finally, (lung, heart, liver, kidney, urogenital organs, reproductive system, bone cartilage, skeletal muscle, endocrine organs) presented, aging) but extending some common pathophysiological conditions. From data, wide array significant all emerges characteristic bell-shaped biphasic effects highlighted. addition, key aspects, debated areas, future research translational areas identified.

Язык: Английский

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Mitochondria and microbiota dysfunction in COVID-19 pathogenesis

Mitochondrion, Год журнала: 2020, Номер 54, С. 1 - 7

Опубликована: Июнь 20, 2020

Язык: Английский

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Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease

Trends in Molecular Medicine, Год журнала: 2020, Номер 26(11), С. 1034 - 1046

Опубликована: Июнь 30, 2020

Inflammatory bowel disease (IBD) is associated with the production of reactive species that target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage, ion transport, intermediary metabolism, and mitochondrial function. Precursors are derived from organic inorganic compounds their cofactors, including amino acids, vitamins, oxygen, nitrite, sulfate. Nutrition gut microbiome fuel this process to a significant extent. The IBD reflected by reduction systemic free thiols, major components antioxidant machinery. Systemic thiols amenable nutritional or therapeutic intervention. This opens up future avenues for modulation status IBD.

Язык: Английский

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On the history of oxidative stress: Concept and some aspects of current development

Current Opinion in Toxicology, Год журнала: 2018, Номер 7, С. 122 - 126

Опубликована: Янв. 11, 2018

Язык: Английский

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A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator

Biochemical Pharmacology, Год журнала: 2017, Номер 149, С. 5 - 19

Опубликована: Сен. 23, 2017

Язык: Английский

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Antioxidants from Plants Protect against Skin Photoaging

Oxidative Medicine and Cellular Longevity, Год журнала: 2018, Номер 2018(1)

Опубликована: Янв. 1, 2018

Exposure to UV light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, with consequent increase oxidative stress thus photoaging. Exogenous supplementation dietary antioxidants and/or pretreatment antioxidant-based lotions before sun exposure might be a winning strategy against age-related pathologies. In this context, plants produce many secondary metabolites protect themselves from radiations these compounds can also Phenolic compounds, ascorbic acid carotenoids, derived different plant species, are able by preventing penetration, reducing inflammation stress, influencing several survival signalling pathways. review, we focus our attention on double role oxidants cell metabolism environmental xenobiotic agents involved Moreover, discuss protective fruits vegetables report their antiaging properties related reduction

Язык: Английский

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Hydrogen sulfide: An endogenous regulator of the immune system

Pharmacological Research, Год журнала: 2020, Номер 161, С. 105119 - 105119

Опубликована: Авг. 8, 2020

Hydrogen sulfide (H2S) is now recognized as an endogenous signaling gasotransmitter in mammals. It produced by mammalian cells and tissues various enzymes - predominantly cystathionine β-synthase (CBS), γ-lyase (CSE) 3-mercaptopyruvate sulfurtransferase (3-MST) but part of the H2S intestinal microbiota (colonic H2S-producing bacteria). Here we summarize available information on production functional role cell types typically associated with innate immunity (neutrophils, macrophages, dendritic cells, natural killer mast basophils, eosinophils) adaptive (T B lymphocytes) under normal conditions it relates to development inflammatory immune diseases. Special attention paid physiological pathophysiological aspects oral cavity colon, where parenchymal are exposed a special "H2S environment" due bacterial production. has many cellular molecular targets. Immune "surrounded" "cloud" H2S, result exogenous from surrounding which, turn, importantly regulates their viability function. Downregulation producing diseases, or genetic defects biosynthetic enzyme systems either lead spontaneous autoimmune disease accelerate onset worsen severity immune-mediated diseases (e.g. rheumatoid arthritis asthma). Low, regulated amounts when therapeutically delivered small molecule donors, improve function protect them against dysfunction induced noxious stimuli reactive oxygen species oxidized LDL). These effects contribute maintenance functions, can stimulate antimicrobial defenses exert anti-inflammatory therapeutic

Язык: Английский

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Oxidative eustress: On constant alert for redox homeostasis

Redox Biology, Год журнала: 2021, Номер 41, С. 101867 - 101867

Опубликована: Янв. 20, 2021

In the open metabolic system, redox-related signaling requires continuous monitoring and fine-tuning of steady-state redox set point. The ongoing oxidative metabolism is a persistent challenge, denoted as eustress, which operates within physiological range that has been called 'Homeodynamic Space', 'Goldilocks Zone' or 'Golden Mean'. Spatiotemporal control achieved by compartmentalized generation removal oxidants. cellular landscape H2O2, major molecule, characterized orders-of-magnitude concentration differences between organelles. This pattern mirrored oxidatively modified proteins, exemplified S-glutathionylated proteins. review presents conceptual background for short-term (non-transcriptional) longer-term (transcriptional/translational) homeostatic mechanisms stress responses. point variable moving target value, modulated circadian rhythm external influence, summarily exposome, includes nutrition lifestyle factors. Emerging fields cell-specific tissue-specific regulation in settings are briefly presented, including new insight into role eustress embryonal development lifespan, skeletal muscle exercise, sleep-wake rhythm, function nervous system with aspects leading to psychobiology.

Язык: Английский

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