Roles of Identified Long Noncoding RNA in Diabetic Nephropathy DOI Creative Commons
Yan Li, Keyang Xu, Kechen Xu

и другие.

Journal of Diabetes Research, Год журнала: 2019, Номер 2019, С. 1 - 8

Опубликована: Фев. 12, 2019

Diabetes mellitus is the leading chronic disease in world, and diabetic nephropathy (DN) as one of its complications could increase mortality. The development DN associated to abnormal hemodynamic factors like cytokine networks intervention metabolic risk blood pressure, glucose, lipid. However, pathogenesis still poorly understood. Although glucose-lowering drugs insulins have significant effects on fluctuation glucose or other continuously damage kidney. Recent studies reported that progression closely related expression long noncoding RNA (lncRNA), which important for early diagnosis targeted DN. In this review, we briefly summarize published functions potential mechanism lncRNA regulation

Язык: Английский

Endoplasmic reticulum stress in diabetic kidney disease: adaptation and apoptosis after three UPR pathways DOI
Ruijing Zhang, Che Bian, Jing Gao

и другие.

APOPTOSIS, Год журнала: 2023, Номер 28(7-8), С. 977 - 996

Опубликована: Июнь 7, 2023

Язык: Английский

Процитировано

25

N6-methyladenosine RNA methylation in diabetic kidney disease DOI Creative Commons

Jiaan Huang,

Fan Yang, Yan Liu

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 171, С. 116185 - 116185

Опубликована: Янв. 18, 2024

Diabetic kidney disease (DKD) is a major microvascular complication of diabetes, and hyperglycemic memory associated with diabetes carries the risk occurrence, even after termination blood glucose injury. The existence supports concept an epigenetic mechanism involving n6-methyladenosine (m6A) modification. Several studies have shown that m6A plays key role in pathogenesis DKD. This review addresses RNA modification progression DKD, including regulatory pathological processes, such as inflammation, oxidative stress, fibrosis, non-coding (nc) RNA. reveals importance occurrence development suggesting may play phenomenon. also discusses how some gray areas, modified multiple enzymes, interact to affect DKD provides countermeasures. In conclusion, this enhances our understanding from perspective modifications new targets for future therapeutic strategies. addition, insights discussed here support effects which far-reaching implications novel treatments. We hypothesize modification, factor regulating in-depth exploration option clinical management patients

Язык: Английский

Процитировано

12

Cadmium-mediated miR-30a-GRP78 leads to JNK-dependent autophagy in chicken kidney DOI

Qunxiang Shi,

Xi Jin, Rui‐Feng Fan

и другие.

Chemosphere, Год журнала: 2018, Номер 215, С. 710 - 715

Опубликована: Окт. 4, 2018

Язык: Английский

Процитировано

74

Astragaloside IV/lncRNA-TUG1/TRAF5 signaling pathway participates in podocyte apoptosis of diabetic nephropathy rats DOI Creative Commons
Lei Xiao, Limei Zhang, Zonglin Li

и другие.

Drug Design Development and Therapy, Год журнала: 2018, Номер Volume 12, С. 2785 - 2793

Опубликована: Сен. 1, 2018

This study aims to figure out the mechanism of astragaloside IV (AS-IV) in protection podocyte apoptosis diabetic nephropathy (DN) rats.Streptozotocin (STZ) was used induce diabetes rats, and rats were treated with 5 mg/kg/d AS-IV for 12 weeks. Albuminuria level, relative TUG1 TRAF5 levels, cleaved-caspase-3 protein levels examined by ELISA, quantitative reverse transcription (qRT)-PCR, Western blot analyses, respectively. The interaction between confirmed RNA pull-down precipitation. TUNEL assay detect apoptosis.Compared control DN had higher albuminuria lower level. treatment attenuated improved level rats. downregulated upregulated high-glucose-treated MPC5 cells, ameliorated In addition, interacted TRAF5, overexpression promoted degradation protein. Besides, modulated expression through regulating TUG1. decreased via TUG1/TRAF5 pathway. Finally, vivo experiment proved that si-TUG1 abrogated protective effect on DN.AS-IV protected from lncRNA-TUG1/TRAF5

Язык: Английский

Процитировано

73

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress DOI Open Access
Adam Włodarski, Justyna Strycharz, Adam Wróblewski

и другие.

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(18), С. 6902 - 6902

Опубликована: Сен. 20, 2020

Oxidative stress (OxS) is the cause and consequence of metabolic syndrome (MetS), incidence economic burden which increasing each year. OxS triggers dysregulation signaling pathways associated with metabolism epigenetics, including microRNAs, are biomarkers disorders. In this review, we aimed to summarize current knowledge regarding interplay between microRNAs in MetS its components. We searched PubMed Google Scholar most relevant studies. Collected data suggested that different sources (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change expression numerous organs involved regulation glucose lipid endothelium. Dysregulated either directly or indirectly affect and/or activity molecules antioxidative (SIRT1, FOXOs, Keap1/Nrf2) along effector enzymes GPx-1, SOD1/2, HO-1), ROS producers NOX4/5), as well genes connected inflammation, sensitivity, metabolism, thus promoting progression imbalance. MicroRNAs appear be important epigenetic modifiers managing delicate redox balance, mediating pro- antioxidant biological impacts. Summarizing, may promising therapeutic targets ameliorating repercussions MetS.

Язык: Английский

Процитировано

65

AGE/RAGE signaling-mediated endoplasmic reticulum stress and future prospects in non-coding RNA therapeutics for diabetic nephropathy DOI Open Access
Nutthapoom Pathomthongtaweechai, Somchai Chutipongtanate

Biomedicine & Pharmacotherapy, Год журнала: 2020, Номер 131, С. 110655 - 110655

Опубликована: Авг. 24, 2020

Disturbance of endoplasmic reticulum (ER) homeostasis triggered by the accumulation unfolded proteins and advanced glycation end-products (AGEs) plays a major role in pathophysiology diabetic nephropathy. Activation receptor for AGEs (RAGE) stimulates NADPH oxidase-mediated reactive oxygen species (ROS) production, leading to ER stress, inflammation, glomerular hypertrophy, podocyte injury, renal fibrosis. A growing body evidence indicates that non-coding RNAs (ncRNAs) could rescue stress inflammation epigenetic modification. This review summarizes ncRNA regulation AGE/RAGE signaling-mediated discusses opportunities challenges ncRNA-loaded extracellular vesicle therapy

Язык: Английский

Процитировано

61

Non-Coding RNA and Diabetic Kidney Disease DOI
Huiwen Ren, Qiuyue Wang

DNA and Cell Biology, Год журнала: 2021, Номер 40(4), С. 553 - 567

Опубликована: Март 18, 2021

Diabetic kidney disease (DKD) is one of the most common chronic microvascular complications diabetes. In addition to characteristic clinical manifestations proteinuria, it also has a complex pathological process that results from combined effects multiple factors involving whole renal structure such as glomeruli, tubules, and blood vessels. Non-coding RNAs (ncRNA) are transcripts with no or low coding potential, among which micro RNA (miRNA) been widely studied functional miRNA involved in regulation potential biomarker for prediction. The abundance long (lncRNA) vivo highly expressed certain degree research progress, but structural similarity makes still challenging. circular (circRNA) its early stages. It more relevant study provide link between diseases other tissues organs. This classification review mainly summarized biogenesis characteristics, mechanism ncRNA-regulating diseases, ways ncRNA prediction biomarker, interaction networks ncRNA.

Язык: Английский

Процитировано

47

Modes of podocyte death in diabetic kidney disease: an update DOI

Anni Jiang,

Anni Song, Chun Zhang

и другие.

Journal of Nephrology, Год журнала: 2022, Номер 35(6), С. 1571 - 1584

Опубликована: Фев. 24, 2022

Язык: Английский

Процитировано

37

Clinical Relevance of lncRNA and Mitochondrial Targeted Antioxidants as Therapeutic Options in Regulating Oxidative Stress and Mitochondrial Function in Vascular Complications of Diabetes DOI Creative Commons
Tarun Pant, Nnamdi Uche, Matea Juric

и другие.

Antioxidants, Год журнала: 2023, Номер 12(4), С. 898 - 898

Опубликована: Апрель 7, 2023

Metabolic imbalances and persistent hyperglycemia are widely recognized as driving forces for augmented cytosolic mitochondrial reactive oxygen species (ROS) in diabetes mellitus (DM), fostering the development of vascular complications such diabetic nephropathy, cardiomyopathy, neuropathy, retinopathy. Therefore, specific therapeutic approaches capable modulating oxidative milieu may provide a preventative and/or benefit against cardiovascular patients. Recent studies have demonstrated epigenetic alterations circulating tissue-specific long non-coding RNA (lncRNA) signatures DM regulating function under stress. Intriguingly, over past decade mitochondria-targeted antioxidants (MTAs) emerged promising option managing stress-induced diseases. Here, we review present status lncRNA diagnostic biomarker potential regulator stress DM. We also discuss recent advances using MTAs different animal models clinical trials. summarize prospects challenges use treating diseases their application translation medicine, which be beneficial MTA drug design development, translational medicine.

Язык: Английский

Процитировано

21

Mechanisms and implications of podocyte autophagy in chronic kidney disease DOI
Rachel Njeim, Sandra Merscher, Alessia Fornoni

и другие.

AJP Renal Physiology, Год журнала: 2024, Номер 326(6), С. F877 - F893

Опубликована: Апрель 11, 2024

Autophagy is a protective mechanism through which cells degrade and recycle proteins organelles to maintain cellular homeostasis integrity. An accumulating body of evidence underscores the significant impact dysregulated autophagy on podocyte injury in chronic kidney disease (CKD). In this review, we provide comprehensive overview diverse types their regulation homeostasis, with specific emphasis podocytes. Furthermore, discuss recent findings that focus functional role different during disease. The intricate interplay between health requires further research, critical for understanding pathogenesis CKD developing targeted therapeutic interventions.

Язык: Английский

Процитировано

7