Journal of Diabetes Research,
Год журнала:
2019,
Номер
2019, С. 1 - 8
Опубликована: Фев. 12, 2019
Diabetes
mellitus
is
the
leading
chronic
disease
in
world,
and
diabetic
nephropathy
(DN)
as
one
of
its
complications
could
increase
mortality.
The
development
DN
associated
to
abnormal
hemodynamic
factors
like
cytokine
networks
intervention
metabolic
risk
blood
pressure,
glucose,
lipid.
However,
pathogenesis
still
poorly
understood.
Although
glucose-lowering
drugs
insulins
have
significant
effects
on
fluctuation
glucose
or
other
continuously
damage
kidney.
Recent
studies
reported
that
progression
closely
related
expression
long
noncoding
RNA
(lncRNA),
which
important
for
early
diagnosis
targeted
DN.
In
this
review,
we
briefly
summarize
published
functions
potential
mechanism
lncRNA
regulation
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
171, С. 116185 - 116185
Опубликована: Янв. 18, 2024
Diabetic
kidney
disease
(DKD)
is
a
major
microvascular
complication
of
diabetes,
and
hyperglycemic
memory
associated
with
diabetes
carries
the
risk
occurrence,
even
after
termination
blood
glucose
injury.
The
existence
supports
concept
an
epigenetic
mechanism
involving
n6-methyladenosine
(m6A)
modification.
Several
studies
have
shown
that
m6A
plays
key
role
in
pathogenesis
DKD.
This
review
addresses
RNA
modification
progression
DKD,
including
regulatory
pathological
processes,
such
as
inflammation,
oxidative
stress,
fibrosis,
non-coding
(nc)
RNA.
reveals
importance
occurrence
development
suggesting
may
play
phenomenon.
also
discusses
how
some
gray
areas,
modified
multiple
enzymes,
interact
to
affect
DKD
provides
countermeasures.
In
conclusion,
this
enhances
our
understanding
from
perspective
modifications
new
targets
for
future
therapeutic
strategies.
addition,
insights
discussed
here
support
effects
which
far-reaching
implications
novel
treatments.
We
hypothesize
modification,
factor
regulating
in-depth
exploration
option
clinical
management
patients
Drug Design Development and Therapy,
Год журнала:
2018,
Номер
Volume 12, С. 2785 - 2793
Опубликована: Сен. 1, 2018
This
study
aims
to
figure
out
the
mechanism
of
astragaloside
IV
(AS-IV)
in
protection
podocyte
apoptosis
diabetic
nephropathy
(DN)
rats.Streptozotocin
(STZ)
was
used
induce
diabetes
rats,
and
rats
were
treated
with
5
mg/kg/d
AS-IV
for
12
weeks.
Albuminuria
level,
relative
TUG1
TRAF5
levels,
cleaved-caspase-3
protein
levels
examined
by
ELISA,
quantitative
reverse
transcription
(qRT)-PCR,
Western
blot
analyses,
respectively.
The
interaction
between
confirmed
RNA
pull-down
precipitation.
TUNEL
assay
detect
apoptosis.Compared
control
DN
had
higher
albuminuria
lower
level.
treatment
attenuated
improved
level
rats.
downregulated
upregulated
high-glucose-treated
MPC5
cells,
ameliorated
In
addition,
interacted
TRAF5,
overexpression
promoted
degradation
protein.
Besides,
modulated
expression
through
regulating
TUG1.
decreased
via
TUG1/TRAF5
pathway.
Finally,
vivo
experiment
proved
that
si-TUG1
abrogated
protective
effect
on
DN.AS-IV
protected
from
lncRNA-TUG1/TRAF5
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(18), С. 6902 - 6902
Опубликована: Сен. 20, 2020
Oxidative
stress
(OxS)
is
the
cause
and
consequence
of
metabolic
syndrome
(MetS),
incidence
economic
burden
which
increasing
each
year.
OxS
triggers
dysregulation
signaling
pathways
associated
with
metabolism
epigenetics,
including
microRNAs,
are
biomarkers
disorders.
In
this
review,
we
aimed
to
summarize
current
knowledge
regarding
interplay
between
microRNAs
in
MetS
its
components.
We
searched
PubMed
Google
Scholar
most
relevant
studies.
Collected
data
suggested
that
different
sources
(e.g.,
hyperglycemia,
insulin
resistance
(IR),
hyperlipidemia,
obesity,
proinflammatory
cytokines)
change
expression
numerous
organs
involved
regulation
glucose
lipid
endothelium.
Dysregulated
either
directly
or
indirectly
affect
and/or
activity
molecules
antioxidative
(SIRT1,
FOXOs,
Keap1/Nrf2)
along
effector
enzymes
GPx-1,
SOD1/2,
HO-1),
ROS
producers
NOX4/5),
as
well
genes
connected
inflammation,
sensitivity,
metabolism,
thus
promoting
progression
imbalance.
MicroRNAs
appear
be
important
epigenetic
modifiers
managing
delicate
redox
balance,
mediating
pro-
antioxidant
biological
impacts.
Summarizing,
may
promising
therapeutic
targets
ameliorating
repercussions
MetS.
Biomedicine & Pharmacotherapy,
Год журнала:
2020,
Номер
131, С. 110655 - 110655
Опубликована: Авг. 24, 2020
Disturbance
of
endoplasmic
reticulum
(ER)
homeostasis
triggered
by
the
accumulation
unfolded
proteins
and
advanced
glycation
end-products
(AGEs)
plays
a
major
role
in
pathophysiology
diabetic
nephropathy.
Activation
receptor
for
AGEs
(RAGE)
stimulates
NADPH
oxidase-mediated
reactive
oxygen
species
(ROS)
production,
leading
to
ER
stress,
inflammation,
glomerular
hypertrophy,
podocyte
injury,
renal
fibrosis.
A
growing
body
evidence
indicates
that
non-coding
RNAs
(ncRNAs)
could
rescue
stress
inflammation
epigenetic
modification.
This
review
summarizes
ncRNA
regulation
AGE/RAGE
signaling-mediated
discusses
opportunities
challenges
ncRNA-loaded
extracellular
vesicle
therapy
DNA and Cell Biology,
Год журнала:
2021,
Номер
40(4), С. 553 - 567
Опубликована: Март 18, 2021
Diabetic
kidney
disease
(DKD)
is
one
of
the
most
common
chronic
microvascular
complications
diabetes.
In
addition
to
characteristic
clinical
manifestations
proteinuria,
it
also
has
a
complex
pathological
process
that
results
from
combined
effects
multiple
factors
involving
whole
renal
structure
such
as
glomeruli,
tubules,
and
blood
vessels.
Non-coding
RNAs
(ncRNA)
are
transcripts
with
no
or
low
coding
potential,
among
which
micro
RNA
(miRNA)
been
widely
studied
functional
miRNA
involved
in
regulation
potential
biomarker
for
prediction.
The
abundance
long
(lncRNA)
vivo
highly
expressed
certain
degree
research
progress,
but
structural
similarity
makes
still
challenging.
circular
(circRNA)
its
early
stages.
It
more
relevant
study
provide
link
between
diseases
other
tissues
organs.
This
classification
review
mainly
summarized
biogenesis
characteristics,
mechanism
ncRNA-regulating
diseases,
ways
ncRNA
prediction
biomarker,
interaction
networks
ncRNA.
Antioxidants,
Год журнала:
2023,
Номер
12(4), С. 898 - 898
Опубликована: Апрель 7, 2023
Metabolic
imbalances
and
persistent
hyperglycemia
are
widely
recognized
as
driving
forces
for
augmented
cytosolic
mitochondrial
reactive
oxygen
species
(ROS)
in
diabetes
mellitus
(DM),
fostering
the
development
of
vascular
complications
such
diabetic
nephropathy,
cardiomyopathy,
neuropathy,
retinopathy.
Therefore,
specific
therapeutic
approaches
capable
modulating
oxidative
milieu
may
provide
a
preventative
and/or
benefit
against
cardiovascular
patients.
Recent
studies
have
demonstrated
epigenetic
alterations
circulating
tissue-specific
long
non-coding
RNA
(lncRNA)
signatures
DM
regulating
function
under
stress.
Intriguingly,
over
past
decade
mitochondria-targeted
antioxidants
(MTAs)
emerged
promising
option
managing
stress-induced
diseases.
Here,
we
review
present
status
lncRNA
diagnostic
biomarker
potential
regulator
stress
DM.
We
also
discuss
recent
advances
using
MTAs
different
animal
models
clinical
trials.
summarize
prospects
challenges
use
treating
diseases
their
application
translation
medicine,
which
be
beneficial
MTA
drug
design
development,
translational
medicine.
AJP Renal Physiology,
Год журнала:
2024,
Номер
326(6), С. F877 - F893
Опубликована: Апрель 11, 2024
Autophagy
is
a
protective
mechanism
through
which
cells
degrade
and
recycle
proteins
organelles
to
maintain
cellular
homeostasis
integrity.
An
accumulating
body
of
evidence
underscores
the
significant
impact
dysregulated
autophagy
on
podocyte
injury
in
chronic
kidney
disease
(CKD).
In
this
review,
we
provide
comprehensive
overview
diverse
types
their
regulation
homeostasis,
with
specific
emphasis
podocytes.
Furthermore,
discuss
recent
findings
that
focus
functional
role
different
during
disease.
The
intricate
interplay
between
health
requires
further
research,
critical
for
understanding
pathogenesis
CKD
developing
targeted
therapeutic
interventions.
