Remote Organ Damage Induced by Stroke: Molecular Mechanisms and Comprehensive Interventions
Antioxidants and Redox Signaling,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Significance:
Damage
after
stroke
is
not
only
limited
to
the
brain
but
also
often
occurs
in
remote
organs,
including
heart,
lung,
liver,
kidney,
digestive
tract,
and
spleen,
which
are
frequently
affected
by
complex
pathophysiological
changes.
The
organs
human
body
closely
connected,
signals
transmitted
through
various
molecular
substances
could
regulate
changes
of
organs.
Recent
Advances:
latest
studies
have
shown
that
inflammatory
response
plays
an
important
role
organ
damage
stroke,
can
aggravate
activating
oxidative
stress,
sympathetic
axis,
hypothalamic
disturbing
immunological
homeostasis.
Remote
cause
brain,
aggravating
damage.
Critical
Issues:
Therefore,
in-depth
exploration
mechanisms
adopting
corresponding
comprehensive
intervention
strategies
become
necessary
reduce
promote
protection.
Future
Directions:
strategy
involves
multifaceted
treatment
methods
such
as
inflammation
regulation,
antioxidants,
neural
stem
cell
differentiation.
It
provides
a
promising
alternative
for
recovery
patients
inspiration
future
research
treatment.
interconnected
at
level.
Only
levels
we
save
protect
greatest
extent.
Antioxid.
Redox
Signal.
00,
000-000.
Язык: Английский
NADPH oxidase 2 activity disrupts Calmodulin/CaMKIIα complex via redox modifications of CaMKIIα-contained Cys30 and Cys289: Implications in Parkinson's disease
Redox Biology,
Год журнала:
2024,
Номер
75, С. 103254 - 103254
Опубликована: Июнь 26, 2024
Ca
Язык: Английский
Flavonoids and other constituents from Jacaranda mimosifolia: In vitro analysis, molecular docking, and molecular dynamic simulations of antioxidant and anti-inflammatory activities
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
182, С. 117768 - 117768
Опубликована: Дек. 17, 2024
Язык: Английский
Molecular Roles of NADPH Oxidase-Mediated Oxidative Stress in Alzheimer’s Disease: Isoform-Specific Contributions
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12299 - 12299
Опубликована: Ноя. 15, 2024
Oxidative
stress
is
linked
to
the
pathogenesis
of
Alzheimer's
disease
(AD),
a
neurodegenerative
disorder
marked
by
memory
impairment
and
cognitive
decline.
AD
characterized
accumulation
amyloid-beta
(Aβ)
plaques
formation
neurofibrillary
tangles
(NFTs)
hyperphosphorylated
tau.
associated
with
an
imbalance
in
redox
states
excessive
reactive
oxygen
species
(ROS).
Recent
studies
report
that
NADPH
oxidase
(NOX)
enzymes
are
significant
contributors
ROS
generation
diseases,
including
AD.
NOX-derived
aggravates
oxidative
neuroinflammation
during
In
this
review,
we
provide
potential
role
all
NOX
isoforms
their
respective
structural
involvement
progression,
highlighting
as
strategic
therapeutic
target.
A
comprehensive
understanding
inhibitors
could
valuable
insights
into
pathology
aid
development
targeted
treatments
for
Язык: Английский
To activate NAD(P)H oxidase with a brief pulse of photodynamic action
The FASEB Journal,
Год журнала:
2024,
Номер
38(23)
Опубликована: Дек. 10, 2024
Reduced
nicotinamide
adenine
dinucleotide
phosphate
[NAD(P)H]
oxidases
(NOX)
are
a
major
cellular
source
of
reactive
oxygen
species,
regulating
vital
physiological
functions,
whose
dys-regulation
leads
to
plethora
diseases.
Much
effort
has
been
made
develop
varied
types
NOX
inhibitors,
but
biotechnologies
for
spatially
and
temporally
controlled
activation,
however,
not
readily
available.
We
previously
found
that
ultraviolet
A
(UVA)
irradiation
activates
NOX2
in
rodent
mast
cells,
elicit
persistent
calcium
spikes.
is
composed
multiple
subunits,
making
studies
its
activation
rather
complicated.
Here
we
show
the
single-subunit
nonrodent-expressing
NOX5,
when
expressed
ectopically
CHO-K1
activated
by
UVA
(380
nm,
0.1-12
mW/cm
Язык: Английский