Adipokines and their potential impacts on susceptibility to myocardial ischemia/reperfusion injury in diabetes
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Ноя. 13, 2024
Abstract
Coronary
artery
disease
has
a
high
mortality
rate
and
is
striking
public
health
concern,
affecting
substantial
portion
of
the
global
population.
On
early
onset
myocardial
ischemia,
thrombolytic
therapy
coronary
revascularization
could
promptly
restore
bloodstream
nutrient
supply
to
ischemic
tissue,
efficiently
preserving
less
severely
injured
myocardium.
However,
abrupt
re-establishment
blood
flow
triggers
significant
discharge
previously
accumulated
oxidative
substances
inflammatory
cytokines,
leading
further
harm
referred
as
ischemia/reperfusion
(I/R)
injury.
Diabetes
significantly
raises
vulnerability
heart
I/R
injury
due
disrupted
glucose
lipid
processing,
impaired
insulin
sensitivity
metabolic
signaling,
increased
responses.
Numerous
studies
have
indicated
that
adipokines
are
crucial
in
etiology
pathogenesis
obesity,
diabetes,
hyperlipidemia,
hypertension,
disease.
Adipokines
such
adiponectin,
adipsin,
visfatin,
chemerin,
omentin,
apelin,
which
possess
protective
properties
against
activity
resistance,
been
shown
confer
protection
conditions
atherosclerosis,
hypertrophy,
injury,
diabetic
complications.
other
hand,
leptin
resistin,
known
for
their
pro-inflammatory
characteristics,
linked
elevated
cardiac
deposition,
fibrosis.
Meteorin-like
(metrnl)
exhibits
opposite
effects
various
pathological
conditions.
data
on
I/R,
especially
still
incomplete
controversial.
This
review
focuses
recent
research
regarding
categorization
function
muscle,
identification
different
signaling
pathways
involved
under
conditions,
aiming
facilitate
exploration
therapeutic
strategies
diabetes.
Язык: Английский
Atherosclerosis in diabetes mellitus: novel mechanisms and mechanism-based therapeutic approaches
Nature Reviews Cardiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Язык: Английский
PD-1 inhibition disrupts collagen homeostasis and aggravates cardiac dysfunction through endothelial-fibroblast crosstalk and EndMT
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 17, 2025
Cardiac
immune-related
adverse
events
(irAEs)
from
PD-1-targeting
immune
check-point
inhibitors
(ICIs)
are
an
increasing
concern
due
to
their
high
mortality
rate.
Collagen
plays
a
crucial
role
in
maintaining
cardiac
structure,
elasticity,
and
signal
transduction;
however,
the
effects
mechanisms
of
PD-1
inhibitor
on
collagen
remodeling
remain
poorly
understood.
C57BL/6
mice
were
injected
with
anti-mouse
antibody
create
inhibitor-treated
model.
function
was
measured
by
echocardiography,
distribution
analyzed
Masson's
trichrome
staining
Sirius
Red
staining.
Single-nucleus
RNA
sequencing
performed
examine
inhibition
gene
expression
fibroblasts
(CFs)
endothelial
cells
(ECs).
EC-CF
crosstalk
assessed
using
co-culture
experiments
ELISA.
ChIP
assay
analyze
regulation
TCF12
TGF-β1
promoter.
Western
blot,
qRT-PCR,
immunofluorescence
used
detect
TCF12,
TGF-β1,
endothelial-to-mesenchymal
transition
(EndMT)
markers.
Reactive
oxygen
species
(ROS)
levels
evaluated
DHE
staining,
MDA
content,
SOD
activity
assays.
We
report
newly
discovered
cardiotoxic
effect
inhibitor,
which
causes
aberrant
heart,
marked
decrease
interstitial
increase
perivascular
deposition.
Mechanistically,
does
not
directly
affect
CFs
but
instead
impact
them
through
crosstalk.
reduces
secretion
ECs
downregulating
we
identify
as
transcriptional
promoter
TGF-β1.
This
subsequently
decreases
CF
activity,
leading
reduced
Additionally,
induces
EndMT,
The
dysfunction
induced
results
ROS
accumulation
ECs.
Inhibiting
N-acetylcysteine
(NAC)
preserves
normal
reversing
downregulation
EndMT
Our
suggest
that
ECs,
imbalanced
(decrease
collagen)
heart
modulating
TCF12/TGF-β1-mediated
EndMT.
NAC
supplementation
could
be
effective
clinical
strategy
mitigate
inhibitor-induced
dysfunction.
Язык: Английский
A Systematic Review of risk factors for major adverse cardiovascular events in patients with coronary heart disease who underwent percutaneous coronary intervention
Frontiers in Physiology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 9, 2025
Objective
This
study
aims
to
systematically
review
the
risk
factors
for
major
adverse
cardiovascular
events
(MACE)
in
patients
with
coronary
heart
disease
who
have
undergone
percutaneous
intervention
(PCI).
Design
Systematic
and
meta-analysis.
Data
sources
The
Cochrane
Library,
PubMed,
Web
of
Science,
China
National
Knowledge
Infrastructure
(CNKI),
Wanfang
Database,
VIP
Database
Chinese
Technical
Periodicals
(VIP)
were
screened
until
December
2024.
Eligibility
criteria
selecting
studies
Case-control
or
cohort
on
MACE
underwent
PCI.
extraction
synthesis:
literature
review,
data
extraction,
quality
evaluation
conducted
by
two
independent
researchers,
meta-analysis
was
performed
using
RevMan
5.4
software.
Main
outcomes
main
outcome
that
occurred
during
follow-up
period.
Results
A
total
40
articles
included.
erevealed
dyslipidemia
(OR
=
1.50;
95%
CI
[1.19,
1.89],
p
0.0007),
diabetes
mellitus
1.70;
[1.43,
2.02],
<
0.00001),
hypertension
1.62;
[1.35,
1.96],
0.0001),
history
smoking
2.08;
[1.51,
2.85],
poorer
ventricular
function
2.39;
[2.17–2.64],
impaired
left
ejection
fraction
(LVEF)
1.86;
[1.71–2.03],
door
balloon
(D-to-B)
time
0.61;
[0.42–0.88];
0.009),
thrombolysis
myocardial
infarction
(TIMI)
1.41;
[1.17,
1.70],
0.0004),
renal
dysfunction
1.82;
[1.37,
2.43],
multi-vessel
artery
0.41;
[0.37,
0.46],
0.0001)
significantly
associated
after
Conclusion
PCI
are
dyslipidemia,
hypertension,
mellitus,
history,
Killip
class
>
II,
LVEF
≤40%,
D-to-B
>90
min,
TIMI
flow
grade
≤
insufficiency,
multivessel
disease.
Язык: Английский
Impact of insulin resistance and microvascular ischemia on myocardial energy metabolism and cardiovascular function: pathophysiology and therapeutic approaches
Cardiovascular Endocrinology & Metabolism,
Год журнала:
2025,
Номер
14(2)
Опубликована: Апрель 16, 2025
Insulin
resistance
(IR)
and
microvascular
ischemia
together
result
in
cardiovascular
dysfunction
by
impairing
the
heart’s
energy
balance.
IR
cardiomyocytes
disrupts
glucose
metabolism,
leading
to
deficits
that
can
drive
cardiac
hypertrophy
heart
failure.
Microvascular
exacerbates
these
effects
limiting
oxygen
nutrient
delivery,
intensifying
oxidative
stress,
mitochondrial
dysfunction,
cell
death.
also
reduces
effectiveness
of
vasodilators
like
nitroglycerin
sodium
nitroprusside,
exacerbating
endothelial
thus
delivery
during
ischemia.
This
combination
heightens
risk
left
ventricular
Understanding
interactions
is
critical
for
developing
targeted
therapies
improve
outcomes
patients
with
ischemic
disease.
study
examines
relationship
between
IR,
ischemia,
myocardial
a
focus
on
clinical
management
therapeutic
strategies.
Язык: Английский
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress
Antioxidants,
Год журнала:
2024,
Номер
13(8), С. 904 - 904
Опубликована: Июль 26, 2024
Radiation-induced
salivary
gland
injury
(RISGI)
is
a
common
complication
of
radiotherapy
in
patients
with
head
and
neck
cancer.
Intragland
expression
the
Sonic
Hedgehog
(Shh)
gene
may
partially
rescue
irradiation
(IR)-induced
hyposalivation
by
preserving
stem/progenitor
cells
parasympathetic
innervation,
maintaining
resident
macrophages,
microvascular
density.
Previous
studies
have
revealed
that
Ad-Rat
Shh
transduction
through
glands
miniature
pigs
can
ameliorate
oxidative
stress-induced
dysfunction
after
radiotherapy.
Changes
parotid
flow
rate
were
analyzed,
tissue
was
collected
at
5
20
weeks
IR.
pathway
vascular
function-related
markers
(vascular
endothelial
growth
factor
(VEGF)
CD31)
stress-related
detected
via
immunohistochemistry,
immunofluorescence,
Western
blotting.
A
stable
Shh-overexpressing
cell
line
generated
from
human
umbilical
vein
(HUVECs)
exposed
to
10
Gy
X-ray
irradiation,
which
proliferation,
senescence,
apoptosis,
function
evaluated.
We
found
intragland
efficiently
alleviated
IR-induced
pig
model.
Our
results
indicate
antioxidative
stress
microvascular-protective
effects
Hh
are
regulated
nuclear
factor-erythroid
2-related
2
(Nrf2).
Язык: Английский
The Overlooked Risk of Venous Thromboembolism in Psychiatric Patients: Epidemiology, Pathophysiology, and Implications for Clinical Care
Seminars in Thrombosis and Hemostasis,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
Abstract
Psychiatric
patients
face
a
significantly
shorter
life
expectancy
than
the
general
population
due
to
complex
interplay
of
medical,
behavioral,
and
social
factors.
Venous
thromboembolism
(VTE),
encompassing
both
pulmonary
embolism
deep
vein
thrombosis,
is
an
underrecognized
yet
critical
contributor
morbidity
mortality
in
this
population.
Evidence
suggests
two
three
times
higher
prevalence
VTE
psychiatric
compared
population,
with
incidence
rates
up
4.5
per
1,000
person-years.
This
elevated
risk
attributed
hypercoagulable-hypofibrinolytic
state.
It
influenced
by
metabolic
abnormalities,
pro-inflammatory
pathways,
antipsychotic
medications,
genetic
Health
care
biases
reduced
treatment
compliance
further
exacerbate
burden.
review
explores
epidemiology,
pathophysiology,
mechanistic
underpinnings
populations,
emphasizing
role
syndrome
therapy.
To
mitigate
enhance
outcomes
for
these
high-risk
individuals,
it
imperative
address
issue
through
improved
stratification
preventive
strategies.
Язык: Английский