The effect of exercise on suicidal ideation and behaviors: A systematic review and meta-analysis of randomized controlled trials

Journal of Affective Disorders, Год журнала: 2023, Номер 330, С. 355 - 366

Опубликована: Март 3, 2023

Язык: Английский

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Exploring the impact of acute physical activity on creative thinking: a comprehensive narrative review with a focus on activity type and intensity

Discover Psychology, Год журнала: 2024, Номер 4(1)

Опубликована: Янв. 11, 2024

Abstract Recent studies have increasingly focused on the cognitive benefits of acute physical activity, particularly in enhancing creative thinking. Despite extensive research linking activity and cognition, significant gaps remain understanding how specific types intensities activities influence this relationship. This review aims to synthesize current findings, highlighting notable impact various One key finding is enhancement divergent thinking, a critical component creativity, through like walking at natural pace. Moderate intensity aerobic exercise dance, though based limited studies, also appear facilitate Additionally, vigorous may enhance secondary aspects including quantity flexibility idea generation. However, identifies multiple gaps, especially effects resistance structured moderate pointing an area ripe for future exploration. Recognizing importance it becomes essential understand different activities, their levels, affect cognition. knowledge can guide both academic practical applications, offering valuable insights targeted strategies aimed function creativity real-world settings such as classrooms workplaces. The underscores need more comprehensive exploration topic, which could implications fields psychology.

Язык: Английский

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Acute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial

EBioMedicine, Год журнала: 2022, Номер 85, С. 104313 - 104313

Опубликована: Окт. 28, 2022

Язык: Английский

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Circulating endocannabinoids and psychological outcomes in women with PTSD

Journal of Anxiety Disorders, Год журнала: 2022, Номер 93, С. 102656 - 102656

Опубликована: Ноя. 23, 2022

Язык: Английский

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Influence of diet on acute endocannabinoidome mediator levels post exercise in active women, a crossover randomized study

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Май 20, 2022

Abstract The extended endocannabinoid system, also termed endocannabinoidome, participates in multiple metabolic functions health and disease. Physical activity can both have an acute chronic impact on mediators, as does diet. In this crossover randomized controlled study, we investigated the influence of diet peripheral response to maximal aerobic exercise a sample active adult women (n = 7) with no underlying conditions. We compared 7-day standardized Mediterranean (MedDiet) control inspired by Canadian macronutrient intake (CanDiet) endocannabinoidome short-chain fatty acid metabolites post exercise. Overall, plasmatic endocannabinoids, their congeners some polyunsaturated acids increased significantly upon cessation recovered initial values within 1 h after Most N -acylethanolamines directly when participants had consumed MedDiet, but not they CanDiet. This was different for monoacylglycerol congeners, which most cases reacted similarly while MedDiet or Fecal microbiota only minimally affected cohort. study demonstrates that mediators respond way is dependent week prior

Язык: Английский

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Endocannabinoids and Stress-Related Neurospsychiatric Disorders: A Systematic Review and Meta-Analysis of Basal Concentrations and Response to Acute Psychosocial Stress

Cannabis and Cannabinoid Research, Год журнала: 2024, Номер 9(5), С. 1217 - 1234

Опубликована: Апрель 29, 2024

Dysregulation of the endocannabinoid (eCB) system is implicated in various stress-related neuropsychiatric disorders (SRDs), including anxiety, depression, and post-traumatic stress disorder (PTSD). In this systematic review meta-analysis, our objectives were to characterize circulating anandamide (AEA) 2-arachidonoylglycerol (2-AG) concentrations at rest response acute laboratory-based psychosocial individuals with SRDs without (controls). Our primary aims assess effects on eCB controls (Aim 1), compare baseline (prestress) between 2), explore differential responses compared 3).

Язык: Английский

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Comparative targeted lipidomics between serum and cerebrospinal fluid of multiple sclerosis patients shows sex and age-specific differences of endocannabinoids and glucocorticoids

Acta Neuropathologica Communications, Год журнала: 2024, Номер 12(1)

Опубликована: Окт. 10, 2024

Multiple sclerosis (MS) is a complex chronic neuroinflammatory disease characterized by demyelination leading to neuronal dysfunction and neurodegeneration manifested various neurological impairments. The endocannabinoid system (ECS) lipid signalling network, which plays multiple roles in the central nervous periphery, including synaptic signal transmission modulation of inflammation. ECS has been identified as potential target for development novel therapeutic interventions MS patients. It remains unclear whether ECS-associated metabolites are changed could serve biomarkers blood or cerebrospinal fluid (CSF). In this retrospective study we applied targeted lipidomics matching CSF serum samples 74 80 non-neuroinflammatory control We found that MS-associated lipidomic changes overall did not coincide between serum. While glucocorticoids correlated positively, only (eCB) 2-arachidonoyl glycerol (2-AG) showed weak positive correlation (r = 0.3, p < 0.05) Peptide endocannabinoids be quantified first time but differ controls. patients elevated levels prostaglandin E2 steaorylethanolamide serum, 2-oleoylglycerol cortisol CSF. Sex-specific differences were showing increased 2-AG males only. Overall, arachidonic acid was males. Interestingly, eCBs positively with age due young relapsing-remitting Our findings reveal significant discrepancies underscoring measuring matrices optimal detecting system. sex age-specific analytes stress axis specifically supports role may relevant drug strategies.

Язык: Английский

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Acute aerobic exercise does not modulate pain potentially due to differences in fitness levels and sex effects – results from a pharmacological fMRI study

Опубликована: Фев. 10, 2025

Exercise might lead to a release of endogenous opioids, potentially resulting in pain relief. However, the neurobiological underpinnings this effect remain unclear. Using pharmacological within-subject fMRI study with opioid antagonist naloxone and different levels aerobic exercise we investigated exercise-induced hypoalgesia ( N = 39, 21 female). Overall, were unable detect reduced after high-intensity as compared low-intensity exercise. Accordingly, observed no significant changes descending modulatory system. The µ-opioid significantly increased overall ratings but showed interaction intensity. An exploratory analysis suggested an influence fitness level sex where males greater increasing levels. This was attenuated by mirrored signal medial frontal cortex, activation also varied sex, reversed naloxone. These results indicate that has on mixed population sample, individual factors such play role.

Язык: Английский

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Acute aerobic exercise does not modulate pain potentially due to differences in fitness levels and sex effects – results from a pharmacological fMRI study

Опубликована: Фев. 10, 2025

Exercise might lead to a release of endogenous opioids, potentially resulting in pain relief. However, the neurobiological underpinnings this effect remain unclear. Using pharmacological within-subject fMRI study with opioid antagonist naloxone and different levels aerobic exercise we investigated exercise-induced hypoalgesia ( N = 39, 21 female). Overall, were unable detect reduced after high-intensity as compared low-intensity exercise. Accordingly, observed no significant changes descending modulatory system. The µ-opioid significantly increased overall ratings but showed interaction intensity. An exploratory analysis suggested an influence fitness level sex where males greater increasing levels. This was attenuated by mirrored signal medial frontal cortex, activation also varied sex, reversed naloxone. These results indicate that has on mixed population sample, individual factors such play role.

Язык: Английский

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Rethinking Depression—Beyond Neurotransmitters: An Integrated Psychoneuroendocrineimmunology Framework for Depression’s Pathophysiology and Tailored Treatment

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2759 - 2759

Опубликована: Март 19, 2025

It is known that the effectiveness of drug treatment for depression, ammine deficit based, largely unsatisfactory. In this review, we examine proposal a precision therapy has emerged and received strong push by identification role inflammation in depression. However, psychiatry risks being caught reductionist trap searching molecular switch resets whole system switches off disease. This an illusion since human complex depression systemic variable disorder. study, show inadequacy paradigm, and, at same time, illustrate superiority paradigm centered on psychoneuroendocrineimmunology (PNEI). According to PNEI disease being, caused different sources working together: psychological, biological, behavioral. means knowing biological psychological history subject, identifying relational crisis factors, building personalized treatments targeting those factors with tools medicine psychology, which are not reducible combination drugs psychotherapy. Our presents shift both theoretical practical, enables clinicians assess patients experiencing unified way treat them integrated manner.

Язык: Английский

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