Cannabidiol and brain function: current knowledge and future perspectives

Frontiers in Pharmacology, Год журнала: 2024, Номер 14

Опубликована: Янв. 15, 2024

Cannabidiol (CBD) is a naturally occurring non-psychoactive cannabinoid found in Cannabis sativa , commonly known as cannabis or hemp. Although currently available CBD products do not meet the safety standards of most food authorities to be approved dietary supplement additive, has been gaining widespread attention recent years due its various potential health benefits. While primarily for therapeutic effects managing epileptic seizures, psychosis, anxiety, (neuropathic) pain, and inflammation, CBD’s influence on brain function also piqued interest researchers individuals seeking enhance cognitive performance. The primary objective this review gather, synthesize, consolidate scientifically proven evidence impact significance treating neurological mental disorders. First, basic background information CBD, including biomolecular properties mechanisms action presented. Next, human provided followed by discussion implications neurotherapeutic agent. effectiveness reducing chronic pain considered but symptoms disorders such epilepsy, Alzheimer’s, Huntington’s Parkinson’s disease. Additionally, using manage psychiatric conditions anxiety fear, depression, substance use are explored. An overview beneficial aspects behavior, sleep, motor control, cognition memory, then provided. As remain largely unregulated, it crucial address ethical concerns associated with their use, product quality, consistency, safety. Therefore, discusses need responsible research regulation ensure efficacy agent stimulate behavioral abilities healthy individuals.

Язык: Английский

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Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators

Cell chemical biology, Год журнала: 2023, Номер 30(12), С. 1508 - 1524.e7

Опубликована: Авг. 29, 2023

Язык: Английский

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Effects of Hemp-Derived Cannabidiol Supplementation on Blood Variables, Carcass Characteristics, and Meat Quality of Goats

Animals, Год журнала: 2024, Номер 14(12), С. 1718 - 1718

Опубликована: Июнь 7, 2024

Stress experienced by animals during pre-mortem management handling significantly affects both their welfare and the quality of meat produced. Using hemp-derived CBD may offer several benefits in alleviating this issue. In study, we investigated effects supplementation on blood variables, growth performance, carcass characteristics, goats. Sixteen crossbred Boer goats were divided into four groups receiving a basal diet supplemented with 0 (control), 0.1, 0.2, or 0.3 mL CBD/30 kg body weight over 90 days. Although growth, pH remained unaffected, influenced variables. Specifically, dietary at 0.1–0.3 increased white cell (WBC) counts, while serum total protein, globulin, sodium, carbon dioxide levels, potentially affecting protein metabolism electrolyte balance. Over time, significant changes noted hematological profiles, kidney markers, some electrolytes, indicating physiological adaptations. Regarding quality, 0.2–0.3 linearly improved color redness stability; moreover, tenderness textural properties, resulting softer texture. However, analysis using an E-nose indicated ammonia organic solvent vapors from higher groups. This study concluded that up to beneficially modulated biomarkers, color, without adverse impacts characteristics

Язык: Английский

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Therapeutic potentials of cannabidiol: Focus on the Nrf2 signaling pathway

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 168, С. 115805 - 115805

Опубликована: Окт. 31, 2023

Cannabidiol (CBD), a cannabinoid that does not create psychoactive activities, has been identified as having multitude of therapeutic benefits. This study delves into the chemical properties, pharmacokinetics, safety and toxicity, pharmacological effects, most importantly, association between potential CBD nuclear factor erythroid 2-related 2 (Nrf2) signaling pathway. The relationship Nrf2 is closely linked to certain proteins are associated with cardiovascular dysfunctions, cancers, neurodegenerative conditions. Specifically, connected initiation progression diverse health issues, including nephrotoxicity, bladder-related diseases, oral mucositis, obesity, myocardial injury angiogenesis, skin-related inflammations, psychotic disorders, neuropathic pain, Huntington's disease, Alzheimer's Parkinson's neuroinflammation, Amyotrophic Lateral Sclerosis, Multiple Sclerosis. zone great interest in medical field, it significantly impact treatment prevention wide-ranging Additional investigation necessary entirely apprehend mechanisms underlying this crucial interplay develop effective interventions.

Язык: Английский

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Annual banned‐substance review 16^th edition—Analytical approaches in human sports drug testing 2022/2023

Drug Testing and Analysis, Год журнала: 2023, Номер 16(1), С. 5 - 29

Опубликована: Ноя. 20, 2023

Abstract In this 16 th edition of the annual banned‐substance review on analytical approaches in human sports drug testing, literature recent developments particular section global anti‐doping efforts that was published between October 2022 and September 2023 is summarized discussed. Most additions to continuously growing portfolio doping control investigations into challenges context adverse findings are presented, taking account existing as well emerging anti‐doping, with specific focus substances methods recognized World Anti‐Doping Agency's Prohibited List. As previous years, put particularly new or enhanced options controls, appreciating exigence core mission and, equally, conflict arising from opposingly trending extent athlete's exposome sensitivity instruments nowadays commonly available laboratories.

Язык: Английский

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Cannabidiol in sports: insights on how CBD could improve performance and recovery

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Сен. 22, 2023

OPINION article Front. Pharmacol., 22 September 2023Sec. Ethnopharmacology Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1210202

Язык: Английский

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The Endocannabinoid System as a Potential Therapeutic Target for Amyotrophic Lateral Sclerosis

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Март 28, 2024

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective loss of motor neurons from the spinal cord, brainstem and cortex. With prevalence about 5.5–9.9 per 100,000 persons, ALS most common form neuron (MND). Although mechanisms underlying pathophysiology this condition are not yet fully understood, it believed that excitotoxicity, inflammation oxidative stress play an important role in death. Despite intensive research, up to point no cure for has been identified. There increasing evidence cannabinoids, due their anti-glutamatergic anti-inflammatory actions, may show neuroprotective effects patients slow progression disease. Furthermore, cannabis-based medicine be useful managing symptoms like pain, spasticity or weight loss. The aim chapter summarize current state research regarding efficacy safety medical cannabis treatment ALS.

Язык: Английский

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Treatment Strategies for Painful Pelvic Floor Conditions: A Focus on the Potential Benefits of Cannabidiol

Biomolecules, Год журнала: 2024, Номер 14(12), С. 1627 - 1627

Опубликована: Дек. 19, 2024

Painful conditions of the pelvic floor include a set disorders region, discreetly prevalent in female population, which pain emerges as predominant symptom. Such have significant impact on quality life they impair couple relationships and promote states anxiety irascibility affected individuals. Although numerous treatment approaches been proposed for management such disorders, there is need to identify strategies muscle relaxation, counter pain, reduce inflammation. The endocannabinoid system (ECS) represents complex spread throughout body involved regulation physiological processes representing potential therapeutic target mood well management. Cannabidiol (CBD), acting ECS, can relief from hyperalgesia allodynia typical affecting relaxation by restoring balance this delicate anatomical region. However, its use currently limited due lack evidence supporting efficacy harmlessness, mechanism action ECS remains partially unexplored day. This comprehensive review literature examines major brings together main CBD disorders.

Язык: Английский

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Multi targets of cannabidiol (CBD) on skeletal mammalian and avian neuromuscular preparations

Natural Product Research, Год журнала: 2023, Номер unknown, С. 1 - 10

Опубликована: Дек. 6, 2023

Cannabidiol (CBD) has been used in diseases that affect the central nervous system. Its effects on peripheral synapses are of great interest, since endocannabinoid receptors expressed muscles. CBD (0.3 mM) was analysed using mammalian and avian neuromuscular preparations, through myographic techniques complementary protocols. Mammalian cells were examined by light microscopy while exogenous acetylcholine (40 µM) potassium chloride (100 added into before at end experiments. Pharmacological tools such as atropine (2 µM), polyethylene glycol (PEG 400, 20 Ca2+ (1.8 mM), F55-6 (20 µg/mL), nifedipine (1.3 assessed with CBD. In mice, causes a facilitatory effect paralysis, whereas avian, paralysis. Concluding, is responsible for activated or inhibited channels, ACh release via muscarinic receptor modulation, inhibition nicotinic leading to blockade, no damage striated muscle cells.

Язык: Английский

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Cannabis in Combat Sports: position statement of the association of ringside physicians

The Physician and Sportsmedicine, Год журнала: 2024, Номер 52(5), С. 432 - 443

Опубликована: Июль 1, 2024

and ARP Position Statement: Based on the available body of scientific evidence with goals promoting safety combat sports athletes striving for advancement clean sport, Association Ringside Physicians recommends following regarding cannabis:• Use marijuana or synthetic cannabinoids by is discouraged due to unproven benefits many known adverse effects. Acute use can impair cognition complex motor function, which likely leads reduced performance in sports. Chronic increase risk heart lung disease, several cancers, schizophrenia, reduce testosterone men fertility. Benefits from cannabis most contexts, including athletic performance, have not been proven.• topical purified CBD neither encouraged nor discouraged.• Since acute intoxication cognitive any athlete suspected at time competition - based clinical judgment should be banned that competition.• Wide-scale regulation quantitative testing has limited usefulness sports, reasons:∘ Cannabis ergogenic ergolytic.∘ Concentrations fluids correlate poorly effects timing use.∘ Access resources varies widely across sporting organizations.

Язык: Английский

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