Journal of Clinical Medicine, Год журнала: 2025, Номер 14(6), С. 2053 - 2053

Опубликована: Март 18, 2025

Regenerative medicine is gaining interest in the medical field due to limitations of conventional treatments, which often fail address underlying cause disease. In recent years, stem cell-based therapies have evolved as a promising alternative approach treat those diseases that cannot be cured using medicine. Adult cells, particularly mesenchymal cells (MSCs), attracted lot attention their ability regenerate and repair human tissues organs. MSCs isolated from adult are well characterized currently most common type for use regenerative However, low number donor tissues, donor-age cell-source related heterogeneity, limited proliferative differentiation potential, early senescence vitro cultures, negatively affect MSC potential. These factors restrict research clinical applications. To overcome these problems, with superior potential required. Induced (iMSCs) obtained induced pluripotent (iPSCs). patient-specific, readily available, relatively and, therefore, can problems associated primary MSCs. this review, authors aim discuss characteristics, The main methods generate iMSCs iPSCs been discussed detail. addition, proposed criteria molecular characterization, applications disease modeling drug discovery, explored

Язык: Английский