The Role of m6A Methylation in Tumor Immunity and Immune-Associated Disorder DOI Creative Commons
Siyu Mu, Kaiyue Zhao, Shanshan Zhong

и другие.

Biomolecules, Год журнала: 2024, Номер 14(8), С. 1042 - 1042

Опубликована: Авг. 22, 2024

N6-methyladenosine (m6A) represents the most prevalent and significant internal modification in mRNA, with its critical role gene expression regulation cell fate determination increasingly recognized recent research. The immune system, essential for defense against infections maintaining stability through interactions other bodily systems, is significantly influenced by m6A modification. This acts as a key post-transcriptional regulator of responses, though effects on different cells vary across diseases. review delineates impact major system-related cancers—including those respiratory, digestive, endocrine, nervous, urinary reproductive, musculoskeletal system malignancies, well acute myeloid leukemia autoimmune We explore pathogenic roles RNA modifications within tumor microenvironment broader highlighting how regulators interact pathways during disease progression. Furthermore, we discuss patterns these can influence susceptibility to immunotherapy, facilitating development diagnostic prognostic models pioneering new therapeutic approaches. Overall, this emphasizes challenges prospective directions m6A-related various systemic diseases throughout body.

Язык: Английский

The Role of m6A Methylation in Tumor Immunity and Immune-Associated Disorder DOI Creative Commons
Siyu Mu, Kaiyue Zhao, Shanshan Zhong

и другие.

Biomolecules, Год журнала: 2024, Номер 14(8), С. 1042 - 1042

Опубликована: Авг. 22, 2024

N6-methyladenosine (m6A) represents the most prevalent and significant internal modification in mRNA, with its critical role gene expression regulation cell fate determination increasingly recognized recent research. The immune system, essential for defense against infections maintaining stability through interactions other bodily systems, is significantly influenced by m6A modification. This acts as a key post-transcriptional regulator of responses, though effects on different cells vary across diseases. review delineates impact major system-related cancers—including those respiratory, digestive, endocrine, nervous, urinary reproductive, musculoskeletal system malignancies, well acute myeloid leukemia autoimmune We explore pathogenic roles RNA modifications within tumor microenvironment broader highlighting how regulators interact pathways during disease progression. Furthermore, we discuss patterns these can influence susceptibility to immunotherapy, facilitating development diagnostic prognostic models pioneering new therapeutic approaches. Overall, this emphasizes challenges prospective directions m6A-related various systemic diseases throughout body.

Язык: Английский

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