Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage
Fluids and Barriers of the CNS,
Год журнала:
2025,
Номер
22(1)
Опубликована: Апрель 14, 2025
Язык: Английский
Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model
Drug Delivery,
Год журнала:
2025,
Номер
32(1)
Опубликована: Апрель 15, 2025
The
dysregulation
of
blood-brain
barrier
(BBB)
activates
pathological
mechanisms
such
as
neuroinflammation
after
traumatic
brain
injury
(TBI),
and
glymphatic
system
dysfunction
accelerates
toxic
waste
accumulation
TBI.
It
is
essential
to
find
an
effective
way
inhibit
inflammation
repair
BBB
TBI;
however,
lasting
drug
therapy
remains
challenging
because
severely
prevents
drugs
from
being
delivered
central
nervous
system.
Transferrin
receptors
(TfRs)
are
mainly
expressed
on
capillary
endothelial
cells.
Here,
we
report
a
TfR-targeted
nanomedicine
for
TBI
treatment
by
penetrating
delivering
fluvoxamine
(Flv).
polypeptide
liposome
loaded
with
Flv
(TPL-Flv)
implements
cell
targeting
ability
human
umbilical
vein
cells
(HUVECs)
in
vitro
detected
flow
cytometry,
safety
was
proved
through
viability
analysis
blood
routine
biochemistry
analysis.
Afterwards,
established
controlled
cortical
impact
model
explore
TPL-Flv
administration
effects
mice.
We
confirmed
that
could
stimulate
CXCR4/SDF-1
signaling
pathway,
activate
Treg
cells,
also
alleviated
disruption
restored
aquaporin-4
(AQP4)
polarization,
well
reversed
dysfunction.
Furthermore,
accomplished
remarkable
improvement
motor
cognitive
functions.
These
findings
demonstrate
can
effectively
cross
achieve
delivery
cerebral
tissue,
validating
its
potential
improve
therapeutic
outcomes
Язык: Английский
Aquaporin 4 and the endocannabinoid system: a potential therapeutic target in brain injury
Experimental Brain Research,
Год журнала:
2024,
Номер
242(9), С. 2041 - 2058
Опубликована: Июль 23, 2024
Brain
edema
is
a
critical
complication
arising
from
stroke
and
traumatic
brain
injury
(TBI)
with
an
important
impact
on
patient
recovery
can
lead
to
long-term
consequences.
Therapeutic
options
reduce
progression
are
limited
variable
outcomes.
Aquaporin
4
(AQP4)
water
channel
that
allows
bidirectional
diffusion
across
the
astrocyte
membrane
participates
in
distinct
phases
of
cerebral
edema.
The
absence
or
inhibition
this
has
been
demonstrated
ameliorate
damage.
endocannabinoid
system
(ECS)
neuromodulator
wide
expression
its
activation
shown
neuroprotective
properties
diverse
models
neuronal
This
review
describes
discusses
major
features
ECS
AQP4
their
role
during
damage,
observing
stimulation
reduces
size
however,
relationship
between
dynamics
remains
unclear.
research
these
topics
holds
promising
therapeutic
implications
for
treatment
following
TBI.
Язык: Английский
Enhancing daily living and cognitive functions in traumatic brain injury patients through Orem’s self-care theory
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 20, 2024
Introduction
This
research
seeks
to
investigate
how
early
rehabilitation
nursing,
guided
by
Orem’s
self-care
theory,
affects
cognitive
function,
neurological
and
daily
living
skills
in
individuals
who
have
suffered
a
traumatic
brain
injury
(TBI).
Methods
A
study
was
conducted
with
108
patients
were
hospitalized
at
our
facility
from
January
2021
March
2023.
Based
on
their
admission
dates,
the
participants
separated
into
control
group
(
n
=
56)
an
observation
52).
The
received
standard
nursing
care,
while
combination
of
conventional
treatment
interventions
based
model.
assessed
alterations
ability
perform
tasks
(Activities
Daily
Living,
ADL),
health
(National
Institutes
Health
Stroke
Scale,
NIHSS;
Glasgow
Coma
GCS),
abilities
(Montreal
Cognitive
Assessment
MoCA;
Mini-Mental
State
Examination,
MMSE)
both
sets
prior
following
4
8
weeks
assistance.
Results
Following
intervention,
being
observed
showed
notably
increased
ADL
scores
p
<
0.001)
comparison
group.
At
after
had
significantly
lower
NIHSS
compared
(4
0.03;
0.001).
GCS
score
similar
results
0.013;
0.003).
Moreover,
higher
MoCA
MMSE
(all
Conclusion
theory
improves
patients’
cognitive,
neurological,
functions
TBI
during
nursing.
method
helps
enhance
level
care
given
healthcare
professionals,
leading
more
thorough
compassionate
for
patients.
Язык: Английский
Potensi Terapi Fitokanabinoid Mayor dalam Pengobatan Cedera Otak Traumatik: sebuah Tinjauan Literatur Farmakologis
KELUWIH Jurnal Kesehatan dan Kedokteran,
Год журнала:
2024,
Номер
6(1)
Опубликована: Дек. 31, 2024
Abstract—Traumatic
brain
injury
(TBI)
is
a
global
health
issue
that
leads
to
long-term
neurological
deficits,
including
cognitive,
motor,
and
mood
disorders.
Current
TBI
treatments
primarily
focus
on
symptom
management,
while
neuroprotective
therapies
remain
in
the
exploratory
stage.
One
promising
approach
use
of
Cannabis
sativa
L.,
which
contains
phytocannabinoids,
compounds
with
potential
effects.
Preclinical
studies
have
shown
major
cannabidiol
(CBD)
tetrahydrocannabinol
(THC),
may
effects
through
mechanisms
such
as
reducing
excitotoxicity,
neuroinflammation,
oxidative
stress.
These
phytocannabinoids
are
known
influence
cannabinoid
receptors
(CB1
CB2),
play
roles
modulating
inflammatory
processes,
neuronal
damage,
improving
motor
cognitive
functions,
regulating
recovery
blood-brain
barrier
intracranial
lymphatics.
This
review
aims
explore
therapeutic
treatment
by
highlighting
pathophysiological
these
compounds.
A
deeper
understanding
action
pave
way
for
development
phytocannabinoid-based
future.
Keywords:
traumatic
injury,
neuroprotection,
cannabis
l.,
cannabidiol,
Abstrak—Cedera
otak
traumatik
(COT)
merupakan
masalah
kesehatan
yang
menyebabkan
defisit
neurologis
jangka
panjang,
termasuk
gangguan
kognitif,
motorik,
dan
suasana
hati.
Pengobatan
COT
saat
ini
lebih
difokuskan
pada
manajemen
gejala,
sementara
pengobatan
bersifat
neuroprotektif
masih
dalam
tahap
eksplorasi.
Salah
satu
pendekatan
menjanjikan
adalah
penggunaan
tanaman
L.
mengandung
fitokanabinoid,
senyawa
memiliki
potensi
neuroprotektif.
Metode
digunakan
kajian
literatur.
Hasil
penelitian
preklinik
menunjukkan
bahwa
fitokanabinoid
mayor
yaitu
kanabidiol
(KBD)
tetrahidrokanabinol
(THC)
dapat
memberikan
efek
melalui
mekanisme
pengurangan
eksitotoksisitas,
neuroinflamasi,
stres
oksidatif.
Senyawa
diketahui
mempengaruhi
reseptor
kanabinoid
(RKB1
RKB2),
berperan
modulasi
proses
inflamasi,
kerusakan
neuron
memperbaiki
fungsi
motorik
serta
mengatur
pemulihan
sawar
darah-otak
limfatik
intrakranial.
literatur
COT.
Pemahaman
tentang
kerja
membuka
jalan
bagi
pengembangan
terapi
berbasis
untuk
di
masa
depan.
Kata
kunci:
cedera
traumatis,
neuroproteksi,
mayor,
kanabidiol,
Язык: Английский