Potensi Terapi Fitokanabinoid Mayor dalam Pengobatan Cedera Otak Traumatik: sebuah Tinjauan Literatur Farmakologis DOI Creative Commons

Arief Gunawan Darmanto

KELUWIH Jurnal Kesehatan dan Kedokteran, Год журнала: 2024, Номер 6(1)

Опубликована: Дек. 31, 2024

Abstract—Traumatic brain injury (TBI) is a global health issue that leads to long-term neurological deficits, including cognitive, motor, and mood disorders. Current TBI treatments primarily focus on symptom management, while neuroprotective therapies remain in the exploratory stage. One promising approach use of Cannabis sativa L., which contains phytocannabinoids, compounds with potential effects. Preclinical studies have shown major cannabidiol (CBD) tetrahydrocannabinol (THC), may effects through mechanisms such as reducing excitotoxicity, neuroinflammation, oxidative stress. These phytocannabinoids are known influence cannabinoid receptors (CB1 CB2), play roles modulating inflammatory processes, neuronal damage, improving motor cognitive functions, regulating recovery blood-brain barrier intracranial lymphatics. This review aims explore therapeutic treatment by highlighting pathophysiological these compounds. A deeper understanding action pave way for development phytocannabinoid-based future. Keywords: traumatic injury, neuroprotection, cannabis l., cannabidiol, Abstrak—Cedera otak traumatik (COT) merupakan masalah kesehatan yang menyebabkan defisit neurologis jangka panjang, termasuk gangguan kognitif, motorik, dan suasana hati. Pengobatan COT saat ini lebih difokuskan pada manajemen gejala, sementara pengobatan bersifat neuroprotektif masih dalam tahap eksplorasi. Salah satu pendekatan menjanjikan adalah penggunaan tanaman L. mengandung fitokanabinoid, senyawa memiliki potensi neuroprotektif. Metode digunakan kajian literatur. Hasil penelitian preklinik menunjukkan bahwa fitokanabinoid mayor yaitu kanabidiol (KBD) tetrahidrokanabinol (THC) dapat memberikan efek melalui mekanisme pengurangan eksitotoksisitas, neuroinflamasi, stres oksidatif. Senyawa diketahui mempengaruhi reseptor kanabinoid (RKB1 RKB2), berperan modulasi proses inflamasi, kerusakan neuron memperbaiki fungsi motorik serta mengatur pemulihan sawar darah-otak limfatik intrakranial. literatur COT. Pemahaman tentang kerja membuka jalan bagi pengembangan terapi berbasis untuk di masa depan. Kata kunci: cedera traumatis, neuroproteksi, mayor, kanabidiol,

Язык: Английский

Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage DOI Creative Commons
Kexin Li, Yuheng Liu,

Junjie Gong

и другие.

Fluids and Barriers of the CNS, Год журнала: 2025, Номер 22(1)

Опубликована: Апрель 14, 2025

Язык: Английский

Процитировано

0

Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model DOI Creative Commons
Liang Mi, Jiangyuan Yuan, Yuxin Jiang

и другие.

Drug Delivery, Год журнала: 2025, Номер 32(1)

Опубликована: Апрель 15, 2025

The dysregulation of blood-brain barrier (BBB) activates pathological mechanisms such as neuroinflammation after traumatic brain injury (TBI), and glymphatic system dysfunction accelerates toxic waste accumulation TBI. It is essential to find an effective way inhibit inflammation repair BBB TBI; however, lasting drug therapy remains challenging because severely prevents drugs from being delivered central nervous system. Transferrin receptors (TfRs) are mainly expressed on capillary endothelial cells. Here, we report a TfR-targeted nanomedicine for TBI treatment by penetrating delivering fluvoxamine (Flv). polypeptide liposome loaded with Flv (TPL-Flv) implements cell targeting ability human umbilical vein cells (HUVECs) in vitro detected flow cytometry, safety was proved through viability analysis blood routine biochemistry analysis. Afterwards, established controlled cortical impact model explore TPL-Flv administration effects mice. We confirmed that could stimulate CXCR4/SDF-1 signaling pathway, activate Treg cells, also alleviated disruption restored aquaporin-4 (AQP4) polarization, well reversed dysfunction. Furthermore, accomplished remarkable improvement motor cognitive functions. These findings demonstrate can effectively cross achieve delivery cerebral tissue, validating its potential improve therapeutic outcomes

Язык: Английский

Процитировано

0

Aquaporin 4 and the endocannabinoid system: a potential therapeutic target in brain injury DOI Creative Commons

Ari Misael Martínez-Torres,

Julio Morán

Experimental Brain Research, Год журнала: 2024, Номер 242(9), С. 2041 - 2058

Опубликована: Июль 23, 2024

Brain edema is a critical complication arising from stroke and traumatic brain injury (TBI) with an important impact on patient recovery can lead to long-term consequences. Therapeutic options reduce progression are limited variable outcomes. Aquaporin 4 (AQP4) water channel that allows bidirectional diffusion across the astrocyte membrane participates in distinct phases of cerebral edema. The absence or inhibition this has been demonstrated ameliorate damage. endocannabinoid system (ECS) neuromodulator wide expression its activation shown neuroprotective properties diverse models neuronal This review describes discusses major features ECS AQP4 their role during damage, observing stimulation reduces size however, relationship between dynamics remains unclear. research these topics holds promising therapeutic implications for treatment following TBI.

Язык: Английский

Процитировано

2

Enhancing daily living and cognitive functions in traumatic brain injury patients through Orem’s self-care theory DOI Creative Commons

Pei Sha,

Xing Gao, Ranbo Yu

и другие.

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Авг. 20, 2024

Introduction This research seeks to investigate how early rehabilitation nursing, guided by Orem’s self-care theory, affects cognitive function, neurological and daily living skills in individuals who have suffered a traumatic brain injury (TBI). Methods A study was conducted with 108 patients were hospitalized at our facility from January 2021 March 2023. Based on their admission dates, the participants separated into control group ( n = 56) an observation 52). The received standard nursing care, while combination of conventional treatment interventions based model. assessed alterations ability perform tasks (Activities Daily Living, ADL), health (National Institutes Health Stroke Scale, NIHSS; Glasgow Coma GCS), abilities (Montreal Cognitive Assessment MoCA; Mini-Mental State Examination, MMSE) both sets prior following 4 8 weeks assistance. Results Following intervention, being observed showed notably increased ADL scores p < 0.001) comparison group. At after had significantly lower NIHSS compared (4 0.03; 0.001). GCS score similar results 0.013; 0.003). Moreover, higher MoCA MMSE (all Conclusion theory improves patients’ cognitive, neurological, functions TBI during nursing. method helps enhance level care given healthcare professionals, leading more thorough compassionate for patients.

Язык: Английский

Процитировано

1

Potensi Terapi Fitokanabinoid Mayor dalam Pengobatan Cedera Otak Traumatik: sebuah Tinjauan Literatur Farmakologis DOI Creative Commons

Arief Gunawan Darmanto

KELUWIH Jurnal Kesehatan dan Kedokteran, Год журнала: 2024, Номер 6(1)

Опубликована: Дек. 31, 2024

Abstract—Traumatic brain injury (TBI) is a global health issue that leads to long-term neurological deficits, including cognitive, motor, and mood disorders. Current TBI treatments primarily focus on symptom management, while neuroprotective therapies remain in the exploratory stage. One promising approach use of Cannabis sativa L., which contains phytocannabinoids, compounds with potential effects. Preclinical studies have shown major cannabidiol (CBD) tetrahydrocannabinol (THC), may effects through mechanisms such as reducing excitotoxicity, neuroinflammation, oxidative stress. These phytocannabinoids are known influence cannabinoid receptors (CB1 CB2), play roles modulating inflammatory processes, neuronal damage, improving motor cognitive functions, regulating recovery blood-brain barrier intracranial lymphatics. This review aims explore therapeutic treatment by highlighting pathophysiological these compounds. A deeper understanding action pave way for development phytocannabinoid-based future. Keywords: traumatic injury, neuroprotection, cannabis l., cannabidiol, Abstrak—Cedera otak traumatik (COT) merupakan masalah kesehatan yang menyebabkan defisit neurologis jangka panjang, termasuk gangguan kognitif, motorik, dan suasana hati. Pengobatan COT saat ini lebih difokuskan pada manajemen gejala, sementara pengobatan bersifat neuroprotektif masih dalam tahap eksplorasi. Salah satu pendekatan menjanjikan adalah penggunaan tanaman L. mengandung fitokanabinoid, senyawa memiliki potensi neuroprotektif. Metode digunakan kajian literatur. Hasil penelitian preklinik menunjukkan bahwa fitokanabinoid mayor yaitu kanabidiol (KBD) tetrahidrokanabinol (THC) dapat memberikan efek melalui mekanisme pengurangan eksitotoksisitas, neuroinflamasi, stres oksidatif. Senyawa diketahui mempengaruhi reseptor kanabinoid (RKB1 RKB2), berperan modulasi proses inflamasi, kerusakan neuron memperbaiki fungsi motorik serta mengatur pemulihan sawar darah-otak limfatik intrakranial. literatur COT. Pemahaman tentang kerja membuka jalan bagi pengembangan terapi berbasis untuk di masa depan. Kata kunci: cedera traumatis, neuroproteksi, mayor, kanabidiol,

Язык: Английский

Процитировано

1