Genetic and peripheral biomarkers of comorbid posttraumatic stress disorder and traumatic brain injury: a systematic review
Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 27, 2025
Background
Posttraumatic
stress
disorder
(PTSD)
commonly
cooccurs
with
traumatic
brain
injury
(TBI)
in
military
populations
and
is
a
significant
predictor
of
poor
long-term
outcomes;
however,
it
unclear
to
what
extent
specific
biological
variables
are
associated
comorbidity.
This
PROSPERO-registered
systematic
review
evaluates
the
current
body
literature
on
genetic
peripheral
biomarkers
comorbid
TBI
PTSD.
Methods
Searches
were
conducted
four
databases
(PubMed,
PsycInfo,
PTSDPubs,
Scopus).
We
included
published
studies
examining
differences
among
civilian,
military,
veteran
participants
both
PTSD
compared
those
alone
as
well
as,
some
cases,
healthy
controls.
Data
extracted
from
evidence
quality
was
assessed.
Results
Our
final
analysis
16
studies,
majority
which
based
data
active
duty
participants.
The
results
suggest
that
multiple
gene
variants
likely
contribute
cumulative
risk
TBI.
An
elevated
circulating
level
pro-inflammatory
cytokine
IL-6
most
consistently
replicated
blood-based
indicator
illness,
mTBI
alone.
Conclusion
Several
protein
markers
cellular
inflammation
appear
be
promising
indicators
chronic
pathology
Additional
research
needed
determine
how
such
factors
indicate,
predict,
comorbidity
they
represent
viable
targets
for
development
novel
diagnostic
tools
therapeutic
interventions.
Язык: Английский
Integration of metabolomic and brain-imaging data highlights pleiotropy among posttraumatic stress disorder, glycoprotein acetyls, and pallidum structure
Biological Psychiatry Global Open Science,
Год журнала:
2025,
Номер
unknown, С. 100482 - 100482
Опубликована: Март 1, 2025
Язык: Английский
APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 25, 2024
A
reduction
in
the
thickness
and
volume
of
brain
entorhinal
cortex
(EC),
together
with
changes
blood
arachidonic
acid
(AA)
docosahexaenoic
(DHA),
are
associated
Alzheimer's
disease
(AD)
among
apolipoprotein
E
ε4
carriers.
Magnetic
Resonance
Imaging
(n
=
631)
plasma
lipidomics
181)
were
performed
using
LIMBIC/CENC
cohort
to
examine
influence
on
AA-
DHA-lipids
EC
relation
mild
traumatic
injury
(mTBI).
Results
showed
that
left
was
higher
carriers
mTBI.
Repeated
mTBI
(r-mTBI)
reduced
right
after
controlling
for
ε4,
age
sex.
Age,
plus
chronicity
linked
increased
White
Matter
Volume
(WMV).
After
sex,
advancing
blast
Grey
(GMV)
thickness.
Among
carriers,
tau
Aβ40
mTBI,
respectively.
Chronic
AA
DHA
ratios
phosphatidylcholine,
ethanolamides,
phosphatidylethanolamine
decreased
GMV
WMV.
Further
research
is
needed
explore
these
as
biomarkers
detecting
AD
pathology
following
Язык: Английский
Exploring metabolomic dynamics in acute stress disorder: amino acids, lipids, and carbohydrates
Frontiers in Genetics,
Год журнала:
2024,
Номер
15
Опубликована: Июль 25, 2024
Acute
Stress
Disorder
(ASD)
is
a
psychiatric
condition
that
can
develop
shortly
after
trauma
exposure.
Although
molecular
studies
of
ASD
are
only
beginning,
groups
metabolites
have
been
found
to
be
significantly
altered
with
acute
stress
phenotypes
in
various
pre-clinical
and
clinical
studies.
implicated
include
amino
acids
(β-hydroxybutyrate,
glutamate,
5-aminovalerate,
kynurenine
aspartate),
ketone
bodies
(β-hydroxybutyrate),
lipids
(cortisol,
palmitoylethanomide,
N-palmitoyl
taurine)
carbohydrates
(glucose
mannose).
Network
pathway
analysis
the
most
prominent
shows
Extracellular
signal-regulated
kinases
c-AMP
response
element
binding
(CREB)
protein
crucial
players.
After
highlighting
main
recent
findings
on
role
ASD,
we
will
discuss
potential
future
directions
challenges
need
tackled.
Overall,
aim
showcase
metabolomics
present
promising
opportunity
advance
our
understanding
pathophysiology
as
well
development
novel
biomarkers
therapeutic
targets.
Язык: Английский
Traumatic brain injury: molecular biomarkers, genetics, secondary consequences, and medical management
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Окт. 4, 2024
Traumatic
brain
injury
(TBI)
has
reached
epidemic
proportions
worldwide.
The
consequences
of
TBI
can
be
severe
even
with
repetitive
mild
trauma.
If
death
and
coma
are
avoided,
the
in
long
term
typically
involve
dizziness,
sleep
disturbances,
headache,
seizures,
cognitive
impairment,
focal
deficits,
depression,
anxiety.
severity
is
a
significant
predictor
outcome.
However,
heterogenous
nature
makes
prognosis
difficult.
present
review
literature
focuses
on
genetics
including
genome
wide
(GWAS)
data
candidate
gene
associations,
among
them
brain-derived
neurotrophic
factor
(BDNF)
development
post-traumatic
epilepsy
(PTE).
Molecular
biomarkers
also
discussed
focus
proteins
inflammatory
protein
IL1-β.
secondary
medical
sequela
to
PTE,
headache
risk
for
neurodegenerative
disorders
discussed.
This
overview
concludes
discussion
management
medicines
used
being
developed
at
preclinical
clinical
stages
treatment
its
host
life-debilitating
symptoms.
Язык: Английский
Omega-3 Fatty Acids and Traumatic Injury in the Adult and Immature Brain
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 4175 - 4175
Опубликована: Ноя. 30, 2024
Traumatic
brain
injury
(TBI)
can
lead
to
substantial
disability
and
health
loss.
Despite
its
importance
impact
worldwide,
no
treatment
options
are
currently
available
help
protect
or
preserve
structure
function
following
injury.
In
this
review,
we
discuss
the
potential
benefits
of
using
omega-3
polyunsaturated
fatty
acids
(O3
PUFAs)
as
therapeutic
agents
in
context
TBI
paediatric
adult
populations.
Язык: Английский