The biophysics of balanced living: a mechano-homeostasis paradigm for balancing in animals and robots DOI Open Access
Nick Wilkinson

Опубликована: Дек. 14, 2024

From birth until death animals resist gravity, effortfully asserting bodily form, animate behaviour, and postural balance. Most basic negentropic behaviours are understood as homeostasis (e.g. thermoregulation), but balance is taken to be an exception. Many studies have elucidated its sub-mechanisms, the existence of goal-oriented homeostatic organisation remains open question. The current theoretical paper reviews existing work highlight challenge assumptions that belie a model, arguing organised one aspect wider mechano-homeostasis, by control loop organisationally akin thermoregulation. biophysical cost maintaining agent-medium density gradient defines task, which regulation mechanical force. Organism-level mechano-homeostasis must approximately maintain certain force field at surface organism (i.e. precisely cancels gravitational acceleration), or will fall, dissipate die. argument specifies this fluid, dynamical ‘balance’ for arbitrary morphologies configurations, describes how apprehend it developmentally their own embodiment. I motivate define examine against evidence, discuss implications, limitations scope understanding embodied spatiotemporal animacy in robots.

Язык: Английский

There’s Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines DOI Creative Commons

Joshua Bongard,

Michael Levin

Biomimetics, Год журнала: 2023, Номер 8(1), С. 110 - 110

Опубликована: Март 8, 2023

The applicability of computational models to the biological world is an active topic debate. We argue that a useful path forward results from abandoning hard boundaries between categories and adopting observer-dependent, pragmatic view. Such view dissolves contingent dichotomies driven by human cognitive biases (e.g., tendency oversimplify) prior technological limitations in favor more continuous view, necessitated study evolution, developmental biology, intelligent machines. Form function are tightly entwined nature, some cases, robotics as well. Thus, efforts re-shape living systems for biomedical or bioengineering purposes require prediction control their at multiple scales. This challenging many reasons, one which perform functions same place time. refer this “polycomputing”—the ability substrate simultaneously compute different things, make those available observers. important way things kind computer, but not familiar, linear, deterministic kind; rather, computers broad sense materials, reported rapidly growing physical computing literature. observer-centered framework computations performed evolved designed will improve understanding mesoscale events, it has already done quantum relativistic To develop our how life performs polycomputing, can be convinced alter functions, we first create technologies polycompute learn functions. Here, review examples idea overloading on hardware design principle helps understand build both systems. Learning hack existing polycomputing substrates, well evolve new ones, have massive impacts regenerative medicine, robotics, computer engineering.

Язык: Английский

Процитировано

39
Biofabrication of Living Actuators DOI
Ritu Raman

Annual Review of Biomedical Engineering, Год журнала: 2024, Номер 26(1), С. 223 - 245

Опубликована: Июль 3, 2024

The impact of tissue engineering has extended beyond a traditional focus in medicine to the rapidly growing realm biohybrid robotics. Leveraging living actuators as functional components machines been central this field, generating range compelling demonstrations robots capable muscle-powered swimming, walking, pumping, gripping, and even computation. In review, we highlight key advances fabricating tissue-scale cardiac skeletal muscle for applications. We discuss areas future growth including scalable manufacturing, integrated feedback control, predictive modeling also propose methods ensuring inclusive bioethics-focused pedagogy emerging discipline. hope review motivates next generation biomedical engineers advance rational design practical use applications ranging from telesurgery manufacturing on- off-world exploration.

Язык: Английский

Процитировано

12
The power of deoxyribonucleic acid and bio-robotics in creating new global revolution: a review DOI Creative Commons

Melaku Mekonen Kasegn,

Hailay Mehari Gebremedhn,

Ashenafi Teklay Yaekob

и другие.

Deleted Journal, Год журнала: 2025, Номер 1(1)

Опубликована: Фев. 12, 2025

Язык: Английский

Процитировано

1
Self-Improvising Memory: A Perspective on Memories as Agential, Dynamically Reinterpreting Cognitive Glue DOI Creative Commons
Michael Levin

Entropy, Год журнала: 2024, Номер 26(6), С. 481 - 481

Опубликована: Май 31, 2024

Many studies on memory emphasize the material substrate and mechanisms by which data can be stored reliably read out. Here, I focus complementary aspects: need for agents to dynamically reinterpret modify memories suit their ever-changing selves environment. Using examples from developmental biology, evolution, synthetic bioengineering, in addition neuroscience, propose that a perspective as preserving salience, not fidelity, is applicable many phenomena scales cells societies. Continuous commitment creative, adaptive confabulation, molecular behavioral levels, answer persistence paradox it applies individuals whole lineages. also speculate substrate-independent, processual view of life mind suggests memories, patterns excitable medium cognitive systems, could seen active sense-making process. explore diverse set embodied perspectives—nested who interpret each other’s own past messages actions best they (polycomputation). This synthesis unifying symmetries across disciplines, relevance research programs Diverse Intelligence engineering novel minds.

Язык: Английский

Процитировано

9
Revealing non-trivial information structures in aneural biological tissues via functional connectivity DOI Creative Commons
Douglas Blackiston, Hannah Dromiack, Caitlin Grasso

и другие.

PLoS Computational Biology, Год журнала: 2025, Номер 21(4), С. e1012149 - e1012149

Опубликована: Апрель 14, 2025

A central challenge in the progression of a variety open questions biology, such as morphogenesis, wound healing, and development, is learning from empirical data how information integrated to support tissue-level function behavior. Information-theoretic approaches provide quantitative framework for extracting patterns data, but so far have been predominantly applied neuronal systems at tissue-level. Here, we demonstrate time series Ca2 + dynamics can be used identify structure other biological tissues. To this end, expressed calcium reporter GCaMP6s an organoid system explanted amphibian epidermis derived African clawed frog Xenopus laevis , imaged activity pre- post- puncture injury, six replicate organoids. We constructed functional connectivity networks by computing mutual between cells using medical imaging techniques track intracellular . analyzed network properties including degree distribution, spatial embedding, modular structure. find exhibit potential evidence more than null models, with our models displaying high hubs mesoscale community clustering. Utilizing networks, model suggests tissue retains non-random features after displays long range correlations structure, non-trivial clustering that not necessarily spatially dependent. In context reconstruction method results suggest increased integration possible cellular coordination response some type generative anatomy. While study epidermal cells, computational approach analyses highlight methods developed analyze tissues generalized any fluorescent signal type. discuss expanded improve non-neuronal processing highlighting bridge neuroscience basal modes processing.

Язык: Английский

Процитировано

1
The Multiple Realizability of Sentience in Living Systems and Beyond DOI Creative Commons
Nicolas Rouleau, Michael Levin

eNeuro, Год журнала: 2023, Номер 10(11), С. ENEURO.0375 - 23.2023

Опубликована: Ноя. 1, 2023

Язык: Английский

Процитировано

12
Mortal Computation: A Foundation for Biomimetic Intelligence DOI Open Access
Alexander G. Ororbia, Karl Friston

Опубликована: Ноя. 17, 2023

This review motivates and synthesizes research efforts in neuroscience-inspired artificial intelligence biomimetic computing terms of mortal computation. Specifically, we characterize the notion mortality by recasting ideas biophysics, cybernetics, cognitive science a theoretical foundation for sentient behavior. We frame computation thesis through Markov blanket formalism circular causality entailed inference, learning, selection. The ensuing framework -- underwritten free energy principle could prove useful guiding construction unconventional connectionist computational systems, neuromorphic intelligence, chimeric agents, including organoids, which stand to revolutionize long-term future embodied, enactive cognition research.

Язык: Английский

Процитировано

11
Exploring the transition: biology, technology, and epistemic activities DOI Creative Commons
Marco Tamborini

Synthese, Год журнала: 2024, Номер 204(1)

Опубликована: Июль 5, 2024

Abstract By focusing on biorobotics, this article explores the epistemological foundations necessary to support transition from biological models technological artifacts. To address transition, I analyze position of German philosopher Thomas Fuchs, who represents one possible approach problem relationship between bio-inspired technology and biology. While Fuchs defends idea a unique ontological space for humans, contends that his categorical distinctions face challenges in establishing robust epistemic foundation ground biology technology. After identifying at least three interwoven reasons rejecting Fuchs’ foundation, ask how, through what methods, by means which practices newly object is accessed shaped. Expanding philosophy science practice, argue plurality answers question provides within different frameworks produce object. In addressing potential pluralistically grounding ones, my helps us: (i) concretize examine models, (ii) investigate features validity objects, effectively offering more concrete pluralistic picture sciences technologies are they can (or cannot) do.

Язык: Английский

Процитировано

4
Synechism 2.0: Contours of a New Theory of Continuity in Bioengineering DOI Creative Commons
Ahti‐Veikko Pietarinen, Vera Shumilina

Biosystems, Год журнала: 2025, Номер unknown, С. 105410 - 105410

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
AggreBots: configuring CiliaBots through guided, modular tissue aggregation DOI Creative Commons
Dhruv Bhattaram, Keyvan Golestan, X. Zhang

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Ciliated biobots, or CiliaBots, are a class of engineered multicellular tissues that capable self-actuated motility propelled by the motile cilia located on their exterior surface. Correlations have been observed between CiliaBot patterns and morphology distribution. However, precise control these structural parameters to generate desired predictably remains lacking. Here, we developed novel Aggregated (AggreBot) platform producing designer through spatially controlled aggregation epithelial spheroids made from human airway cells (referred as Building Blocks CBBs), yielding AggreBots with configurable geometry distribution active cilia. Guided multi-CBB led production rod-, triangle-, diamond-shaped AggreBots, which consistently effected greater than traditional single-spheroid CiliaBots. Furthermore, CBBs were found maintain internal boundaries post-aggregation combined action pathways controlling cellular fluidity tissue polarity. This boundary fidelity, use immotile due mutations in CCDC39 gene, allowed for generation hybrid precision over coverage cilia, further empowering patterns. Our results demonstrate potential self-propelling biological establishment morphological "levers" alterations can be theoretically planned experimentally verified.

Язык: Английский

Процитировано

0