Thyroid Function, Inflammatory Response, and Glucocorticoids in COVID-19

Frontiers in Endocrinology, Год журнала: 2022, Номер 13

Опубликована: Июль 29, 2022

The ongoing COVID-19 pandemic calls for extensive research on various medical topics. Since the beginning of pandemic, multiple studies investigated impact SARS CoV-2 thyroid function. However, crucial data, such as trend progression over time or influence commonly used drugs, might still be missing. We checked function in 174 patients with PCR-confirmed COVID-19. Our covered three separate points hospitalization (days 1, 4, and 10). did not exclude treated glucocorticoids but, instead, compared them steroids. correlated results tests markers systemic inflammation. if abnormal can predict unfavorable outcomes defined combined primary endpoint and/or secondary endpoints; was occurrence death, mechanical ventilation, non-invasive vasopressor infusion, prolonged hospital stay, any listed events. In general, 80.46% evaluated displayed abnormalities at least one point throughout observation. noticed a high prevalence features typical dysfunction non-thyroidal illness (NTI). Free triiodothyronine (fT3) concentration significantly lower group requiring glucocorticoids. Patients displaying were statistically more likely to meet predefined endpoint. found that fT3 measured admission could perceived an independent predictor completion all analyzed groups. Thyroid involvement is common study supports idea being important clinical tools allowing early recognition possible detrimental disease.

Язык: Английский

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Thyroxine changes in COVID-19 pandemic: A systematic review and meta-analysis

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Фев. 13, 2023

Objective COVID-19 infection may affect thyroid function. However, changes in function patients have not been well described. This systematic review and meta-analysis assess thyroxine levels patients, compared with non-COVID-19 pneumonia healthy cohorts during the epidemic. Methods A search was performed English Chinese databases from inception to August 1, 2022. The primary analysis assessed comparing cohorts. Secondary outcomes included different severity prognoses of patients. Results total 5873 were enrolled study. pooled estimates TSH FT3 significantly lower than cohort (P < 0.001), whereas FT4 higher 0.001). Patients non-severe showed significant severe (I 2 = 89.9%, P 0.002) 91.9%, Standard mean differences (SMD) TSH, FT3, survivors non-survivors 0.29 ( 0.006), 1.11 0.22 For ICU had (SMD=0.47, =0.003) (SMD=0.51, P=0.001) non-survivors. Conclusions Compared cohort, decreased increased FT4, similar pneumonia. Thyroid related COVID-19. Thyroxine clinical significance for prognosis evaluation, especially FT3.

Язык: Английский

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Analysis of thyroid function in Japanese patients with coronavirus disease 2019

Endocrine Journal, Год журнала: 2021, Номер 69(6), С. 643 - 648

Опубликована: Дек. 23, 2021

Thyroid dysfunction that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) becoming increasingly recognized. However, only a few reports in Japan have addressed this issue to date. In study, we sought clarify whether infection with SARS-CoV-2 affected thyroid hormone levels and these hormones could be better predictors of prognosis patients disease 2019 (COVID-19). Accordingly, retrospectively examined 147 cases wherein were measured at the time admission among 848 Japanese COVID-19 admitted Hyogo Prefectural Kakogawa Medical Center. All underwent function testing upon hospital admission. More than half (59.1%) euthyroid. Twenty-four percent had serum thyroid-stimulating (TSH) lower reference range normal free thyroxine (fT4) levels, 3.4% low TSH high fT4 levels. Over 70% moderate triiodothyronine (fT3) Serum fT3 inversely correlated severity. The mortality rate was significantly higher those

Язык: Английский

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The impact of covid-19 on thyroid function tests in pregnancy

Endocrine, Год журнала: 2022, Номер 79(3), С. 502 - 511

Опубликована: Ноя. 11, 2022

Язык: Английский

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Thr92Ala-DIO2 heterozygosity is associated with skeletal muscle mass and myosteatosis in patients with COVID-19

European Thyroid Journal, Год журнала: 2024, Номер 13(4)

Опубликована: Июнь 13, 2024

Introduction The type 2 deiodinase and its Thr92Ala-DIO2 polymorphism have been linked to clinical outcomes in acute lung injury coronavirus disease 2019 (COVID-19). Objective objective was identify a potential association between body composition (appendicular muscle mass, myosteatosis, fat distribution) determine whether they reflect the severity or mortality associated with disease. Methods In this prospective cohort study (June–August 2020), 181 patients hospitalized moderate-to-severe COVID-19 underwent non-contrast-enhanced computed tomography (CT) of thorax assess composition, laboratory tests, genotyping for polymorphism. Results total, consecutive were stratified into three subgroups according genotype: Thr/Thr ( n = 64), Thr/Ala 96), Ala/Ala 21). prevalence low area (MA) (< 92 cm²) 52.5%. Low MA less frequent Ala/Thr (44.8%) than (60.9%) (61.9%) P 0.027). Multivariate logistic regression analysis confirmed that allele reduced risk (41% 69%) myosteatosis (62% 72%) compared + (overdominant model). Kaplan–Meier curves showed mass homozygosity had lower survival rates other groups. Notably, heterozygotes ≥92 cm² exhibited best rate. Conclusion heterozygosity is increased skeletal COVID-19. protective effect on restricted MA.

Язык: Английский

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