European Thyroid Journal,
Год журнала:
2024,
Номер
13(4)
Опубликована: Июнь 13, 2024
Introduction
The
type
2
deiodinase
and
its
Thr92Ala-DIO2
polymorphism
have
been
linked
to
clinical
outcomes
in
acute
lung
injury
coronavirus
disease
2019
(COVID-19).
Objective
objective
was
identify
a
potential
association
between
body
composition
(appendicular
muscle
mass,
myosteatosis,
fat
distribution)
determine
whether
they
reflect
the
severity
or
mortality
associated
with
disease.
Methods
In
this
prospective
cohort
study
(June–August
2020),
181
patients
hospitalized
moderate-to-severe
COVID-19
underwent
non-contrast-enhanced
computed
tomography
(CT)
of
thorax
assess
composition,
laboratory
tests,
genotyping
for
polymorphism.
Results
total,
consecutive
were
stratified
into
three
subgroups
according
genotype:
Thr/Thr
(
n
=
64),
Thr/Ala
96),
Ala/Ala
21).
prevalence
low
area
(MA)
(<
92
cm²)
52.5%.
Low
MA
less
frequent
Ala/Thr
(44.8%)
than
(60.9%)
(61.9%)
P
0.027).
Multivariate
logistic
regression
analysis
confirmed
that
allele
reduced
risk
(41%
69%)
myosteatosis
(62%
72%)
compared
+
(overdominant
model).
Kaplan–Meier
curves
showed
mass
homozygosity
had
lower
survival
rates
other
groups.
Notably,
heterozygotes
≥92
cm²
exhibited
best
rate.
Conclusion
heterozygosity
is
increased
skeletal
COVID-19.
protective
effect
on
restricted
MA.
Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Июль 29, 2022
The
ongoing
COVID-19
pandemic
calls
for
extensive
research
on
various
medical
topics.
Since
the
beginning
of
pandemic,
multiple
studies
investigated
impact
SARS
CoV-2
thyroid
function.
However,
crucial
data,
such
as
trend
progression
over
time
or
influence
commonly
used
drugs,
might
still
be
missing.
We
checked
function
in
174
patients
with
PCR-confirmed
COVID-19.
Our
covered
three
separate
points
hospitalization
(days
1,
4,
and
10).
did
not
exclude
treated
glucocorticoids
but,
instead,
compared
them
steroids.
correlated
results
tests
markers
systemic
inflammation.
if
abnormal
can
predict
unfavorable
outcomes
defined
combined
primary
endpoint
and/or
secondary
endpoints;
was
occurrence
death,
mechanical
ventilation,
non-invasive
vasopressor
infusion,
prolonged
hospital
stay,
any
listed
events.
In
general,
80.46%
evaluated
displayed
abnormalities
at
least
one
point
throughout
observation.
noticed
a
high
prevalence
features
typical
dysfunction
non-thyroidal
illness
(NTI).
Free
triiodothyronine
(fT3)
concentration
significantly
lower
group
requiring
glucocorticoids.
Patients
displaying
were
statistically
more
likely
to
meet
predefined
endpoint.
found
that
fT3
measured
admission
could
perceived
an
independent
predictor
completion
all
analyzed
groups.
Thyroid
involvement
is
common
study
supports
idea
being
important
clinical
tools
allowing
early
recognition
possible
detrimental
disease.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 13, 2023
Objective
COVID-19
infection
may
affect
thyroid
function.
However,
changes
in
function
patients
have
not
been
well
described.
This
systematic
review
and
meta-analysis
assess
thyroxine
levels
patients,
compared
with
non-COVID-19
pneumonia
healthy
cohorts
during
the
epidemic.
Methods
A
search
was
performed
English
Chinese
databases
from
inception
to
August
1,
2022.
The
primary
analysis
assessed
comparing
cohorts.
Secondary
outcomes
included
different
severity
prognoses
of
patients.
Results
total
5873
were
enrolled
study.
pooled
estimates
TSH
FT3
significantly
lower
than
cohort
(P
<
0.001),
whereas
FT4
higher
0.001).
Patients
non-severe
showed
significant
severe
(I
2
=
89.9%,
P
0.002)
91.9%,
Standard
mean
differences
(SMD)
TSH,
FT3,
survivors
non-survivors
0.29
(
0.006),
1.11
0.22
For
ICU
had
(SMD=0.47,
=0.003)
(SMD=0.51,
P=0.001)
non-survivors.
Conclusions
Compared
cohort,
decreased
increased
FT4,
similar
pneumonia.
Thyroid
related
COVID-19.
Thyroxine
clinical
significance
for
prognosis
evaluation,
especially
FT3.
Endocrine Journal,
Год журнала:
2021,
Номер
69(6), С. 643 - 648
Опубликована: Дек. 23, 2021
Thyroid
dysfunction
that
is
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
becoming
increasingly
recognized.
However,
only
a
few
reports
in
Japan
have
addressed
this
issue
to
date.
In
study,
we
sought
clarify
whether
infection
with
SARS-CoV-2
affected
thyroid
hormone
levels
and
these
hormones
could
be
better
predictors
of
prognosis
patients
disease
2019
(COVID-19).
Accordingly,
retrospectively
examined
147
cases
wherein
were
measured
at
the
time
admission
among
848
Japanese
COVID-19
admitted
Hyogo
Prefectural
Kakogawa
Medical
Center.
All
underwent
function
testing
upon
hospital
admission.
More
than
half
(59.1%)
euthyroid.
Twenty-four
percent
had
serum
thyroid-stimulating
(TSH)
lower
reference
range
normal
free
thyroxine
(fT4)
levels,
3.4%
low
TSH
high
fT4
levels.
Over
70%
moderate
triiodothyronine
(fT3)
Serum
fT3
inversely
correlated
severity.
The
mortality
rate
was
significantly
higher
those
European Thyroid Journal,
Год журнала:
2024,
Номер
13(4)
Опубликована: Июнь 13, 2024
Introduction
The
type
2
deiodinase
and
its
Thr92Ala-DIO2
polymorphism
have
been
linked
to
clinical
outcomes
in
acute
lung
injury
coronavirus
disease
2019
(COVID-19).
Objective
objective
was
identify
a
potential
association
between
body
composition
(appendicular
muscle
mass,
myosteatosis,
fat
distribution)
determine
whether
they
reflect
the
severity
or
mortality
associated
with
disease.
Methods
In
this
prospective
cohort
study
(June–August
2020),
181
patients
hospitalized
moderate-to-severe
COVID-19
underwent
non-contrast-enhanced
computed
tomography
(CT)
of
thorax
assess
composition,
laboratory
tests,
genotyping
for
polymorphism.
Results
total,
consecutive
were
stratified
into
three
subgroups
according
genotype:
Thr/Thr
(
n
=
64),
Thr/Ala
96),
Ala/Ala
21).
prevalence
low
area
(MA)
(<
92
cm²)
52.5%.
Low
MA
less
frequent
Ala/Thr
(44.8%)
than
(60.9%)
(61.9%)
P
0.027).
Multivariate
logistic
regression
analysis
confirmed
that
allele
reduced
risk
(41%
69%)
myosteatosis
(62%
72%)
compared
+
(overdominant
model).
Kaplan–Meier
curves
showed
mass
homozygosity
had
lower
survival
rates
other
groups.
Notably,
heterozygotes
≥92
cm²
exhibited
best
rate.
Conclusion
heterozygosity
is
increased
skeletal
COVID-19.
protective
effect
on
restricted
MA.