DMW - Deutsche Medizinische Wochenschrift

DMW - Deutsche Medizinische Wochenschrift, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study

Язык: Английский

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Psychometric analysis of the modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) in a prospective multicentre study

BMJ Open Respiratory Research, Год журнала: 2024, Номер 11(1), С. e002271 - e002271

Опубликована: Май 1, 2024

Background Long COVID (LC) is a novel multisystem clinical syndrome affecting millions of individuals worldwide. The modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) condition-specific patient-reported outcome measure designed for assessment and monitoring people with LC. Objectives To evaluate the psychometric properties C19-YRSm in prospective sample Methods 1314 patients attending 10 UK specialist LC clinics completed EuroQol 5D-5L (EQ-5D-5L) longitudinally. characteristics were derived subscales (Symptom Severity (SS), Functional Disability (FD) Overall Health (OH)) internal consistency (Cronbach’s alpha). Convergent validity was assessed using Assessment Chronic Illness Therapy (FACIT)—Fatigue Scale. Known groups Other Symptoms subscale as tertiles, well by hospitalisation intensive care admission. Responsiveness test–retest reliability evaluated EQ-5D-5L. minimal important difference (MID) clinically (MCID) estimated. Confirmatory factor analysis applied to determine instrument’s two-factor structure. Results demonstrated good scale characteristic properties. Item-total correlations between 0.37 0.65 (for SS FD), alphas>0.8). Item ranged 0.46 0.72. FACIT (−0.46 −0.62). three discriminated different levels symptom burden (p<0.001) admitted hospital care. There moderate responsiveness ranging from 0.22 (OH) 0.50 (SS) which greater than Test–retest both 0.86 FD 0.78. MID 2 SS, 1 OH; MCID 4 FD. supported Conclusions condition-specific, reliable, valid responsive

Язык: Английский

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Health-Related Quality of Life in Long COVID: Mapping the Condition-Specific C19-YRSm Measure Onto the EQ-5D-5L

Patient Related Outcome Measures, Год журнала: 2025, Номер Volume 16, С. 55 - 66

Опубликована: Янв. 1, 2025

Long COVID (LC) is a clinical syndrome with persistent, fluctuating symptoms subsequent to COVID-19 infection. LC has significant detrimental effects on health-related quality of life (HRQoL), activities daily living (ADL), and work productivity. Condition-specific patient-reported outcome measures (PROMs), such as the modified Yorkshire Rehabilitation Scale (C19-YRSm) do not provide health utility data required for cost-utility analyses interventions. The aim this study was derive mapping algorithm C19-YRSm enable utilities be generated from PROM. Data were collected large evaluating services in UK. A total 1434 people had completed both EQ-5D. Correlation linear regression applied determine items covariates inclusion algorithm. Model fit, mean differences across range EQ-5D-3L scores, Bland-Altman plots evaluated. Responsiveness (standardised response mean; SRM) mapped investigated subset participants repeat assessments. There strong level association between 8 one domain EQ-5D single-item dimensions. fit good (R2 = 0.7). difference observed scores <0.10 0 1 indicating targeting positive values EQ-5D-3L. SRM 0.37 compared 0.17 suggesting more responsive change. simple, responsive, robust developed generate C19-YRSm. This will facilitate economic evaluations interventions, treatment, management, well further helping describe characterise patients irrespective any treatment

Язык: Английский

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Effect of telerehabilitation on post-COVID-19 individuals with long-term dyspnea: A randomized controlled study

Journal of Telemedicine and Telecare, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Objective This study aimed to determine the effectiveness of telerehabilitation in managing ongoing dyspnea and associated issues following coronavirus disease 2019 (COVID-19), observe changes over time. Design The included 36 participants who previously had COVID-19 but continued experience (mean age, 42.44 ± 15.51 years). were randomly allocated into three groups: (TRG), home exercise (HEG), control (CG). Dyspnea level, capacity, muscle oxygenation, respiratory function, fatigue evaluated at baseline, 6th, 12th weeks. Telerehabilitation was performed supervised synchronously via video-calls. Results At 6-week assessment, TRG showed significant improvements dyspnea, (p < 0.001), capacity = strength 0.001). By week, these gains maintained, with no further from week 6. In HEG, improved weeks 6 12 additional between time points. CG, only both assessments 0.001); other parameters remained unchanged. achieved greater benefits compared CG reducing 0.001 p 0.003, respectively), group differences found > 0.05). No oxygenation observed any groups or evaluation points Conclusions effectively sustained fatigue, strength, patients post-COVID, while home-based exercises reduced fatigue. Supervised structured may be a viable approach post-COVID-19 symptoms.

Язык: Английский

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Nachsorgeambulanzen für Patient*innen mit Post-COVID: eine Befragung zur Bestandsaufnahme und Charakterisierung von Versorgungsaspekten

DMW - Deutsche Medizinische Wochenschrift, Год журнала: 2024, Номер 149(09), С. e48 - e57

Опубликована: Апрель 1, 2024

Zusammenfassung Nach akuter Infektion mit dem SARS-CoV-2-Virus leiden bis zu 10 % der Erkrankten an längerfristigen gesundheitlichen Beeinträchtigungen, sogenannten „Long-COVID-Syndrom“. Zur Versorgung dieser Patient*innen wurden in Deutschland spezialisierte Ambulanzen eingerichtet. Eine strukturierte Erfassung Versorgungssituation ist für eine bedarfsgerechte essenziell. Ziel vorliegenden Studie strukturelle und prozessbezogene Versorgungsaspekte von Long-COVID-Ambulanzen darzustellen. Mittels Online-Befragung Aspekte wie Struktur Organisation Ambulanzen, Leistungsangebote Vernetzung erhoben. Insgesamt konnten 95 identifiziert werden. Die Einladung Ambulanzleiter*innen zur Teilnahme Befragung erfolgte per E-Mail. Datenerhebung fand zwischen Februar Mai 2022 statt. Auswertung Daten deskriptiv. haben 28 (29 %) Umfrage teilgenommen. Befragten waren 32 66 Jahre alt; 61 davon (n = 17) männlich. am häufigsten die Fachbereiche Pneumologie 10; 36 %), Innere Medizin, Psychiatrie Psychosomatische Medizin sowie Neurologie (jeweils n 8; 29 angegliedert. Aussage betrug Wartezeit auf einen Termin 64 Fälle 18) mehr als Monat. Auslastung 25; 89 Terminnachfrage 26; 93 Bedarf weiteren Post-COVID-Ambulanzen 20; 71 den hoch bewertet. Nahezu alle gaben an, klinikinternen Einrichtungen 27; 96 Haus- niedergelassenen Fachärzt*innen 21; 75 vernetzt sein. Ergebnisse zeigen Schwerpunkt im Bereich gleichen Teilen Inneren Psychiatrie/Psychosomatik Neurologie. Weiterhin weisen hohen Notwendigkeit des Ausbaus dieses Versorgungsangebotes hin.

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Course of fatigue among patients previously hospitalised due to COVID-19

Neurologia i Neurochirurgia Polska, Год журнала: 2023, Номер 57(1), С. 101 - 110

Опубликована: Фев. 22, 2023

Язык: Английский

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Advance in the mechanism and clinical research of myalgia in long COVID

American journal of clinical and experimental immunology., Год журнала: 2024, Номер 13(4), С. 142 - 164

Опубликована: Янв. 1, 2024

As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve, mortality rates of disease 2019 (COVID-19) have significantly decreased. However, a variable proportion patients exhibit persistent prolonged symptoms COVID-19 infection (long COVID). This virus primarily attacks system, but numerous individuals complain skeletal muscle pain or worsening pre-existing post COVID-19, which severely affects the quality life and recovery. Currently, there is limited research on in long COVID. In this brief review, we review potential pathological mechanisms COVID, summarize various auxiliary examinations treatments for We consider abnormal activation inflammatory response, myopathy, neurological damages as pivotal A comprehensive examination important order work out effective treatment plans relieve pain. So far, rehabilitation interventions myalgia COVID contain are not drug, nutraceutical therapy, gut microbiome-targeted interventional therapy strength training. Our study provides mechanism reference clinical researches, highlighting importance approach management The relief will accelerate process, improve activities daily living enhance life, promoting return society with profound significance.

Язык: Английский

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Psychometric analysis of the modified Covid-19 Yorkshire Rehabilitation Scale (C19-YRSm) in a prospective multicentre study

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Дек. 24, 2023

Abstract Bckground Long COVID is a novel multisystem clinical syndrome affecting millions of individuals worldwide. The modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) condition-specific patient-reported outcome measure designed for assessment and monitoring people with (LC). Objectives To evaluate the psychometric properties C19-YRSm in prospective sample COVID. Methods 1314 patients attending UK specialist clinics completed EQ-5D-5L longitudinally. characteristics were derived subscales (Symptom Severity, SS; Functional Disability, FD; Overall Health, OH) internal consistency (Cronbach’s alpha). Convergent validity was assessed using FACIT-Fatigue scale. Known groups Other Symptoms (OS) subscale as tertiles, hospitalisation intensive care admission. Responsiveness test-retest reliability evaluated EQ-5D-5L. minimal important difference (MID) clinically (MCID) estimated. Confirmatory factor analysis applied to determine instrument’s two-factor structure. Results demonstrated good scale characteristic properties. Item-total correlations between 0.37 0.65 (for SS FD), alphas >0.8). Item ranged 0.46 0.72. FACIT (−0.46 −0.62). three discriminated different levels symptom burden (p<0.001), admitted hospital care. There moderate responsiveness ranging from 0.22 (OH) 0.50 (SS) greater than Test-retest both 0.86 FD 0.78. MID 2 SS, FD, 1 OH; MCID 4 FD. supported Conclusions condition-specific, reliable, valid, responsive Key messages What already known on this topic Covid or Post-COVID-19 multisystem, fluctuating condition. literature’s first patient reported which needed validation large population sample. study adds easy administer able show meaningful change status condition living Covid. How might affect research, practice policy can be used research settings reliably capture trajectory effect interventions also help inform policy.

Язык: Английский

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Long COVID symptoms and associated factors in registered nurses with COVID-19

The Journal of Korean Academic Society of Nursing Education, Год журнала: 2024, Номер 30(1), С. 49 - 60

Опубликована: Фев. 28, 2024

Purpose: The coronavirus disease 2019 (COVID-19) pandemic has had significant physical and psychological impacts on registered nurses (RNs). This study aimed to identify long COVID symptoms their associated factors specifically among RNs.Methods: descriptive correlational study’s sample comprised 189 (31.57±5.98 years, 93.7% female) in Korea. Self-reported were assessed using the COVID-19 Yorkshire Rehabilitation Scale. Data collected from December 31, 2022, January 13, 2023, online survey method analyzed independent t-test, Wilcoxon signed-rank test, one-way ANOVA, Pearson’s correlation, a multiple linear regression analysis with IBM SPSS Statistics 26.0 program.Results: A total of 179 participants (94.7%) experienced one or more symptoms. most prevalent weakness (77.8%), fatigue (68.3%), breathlessness (67.7%), cough/throat sensitivity/voice change (50.3%), sleep problems (50.3%). related marital status, type institution, working time, acute symptoms, vaccination status. quarantine period (β=.26, p<.001) nursing workforce after (β=-.17, p=.018) significantly (Adjusted R²=.33).Conclusion: Providing comprehensive recognition is necessary for understanding could promote symptom management education program targeted at nurses. Moreover, it facilitate effective care plans patients.

Язык: Английский

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Health-related quality of life in Long COVID: Mapping the condition-specific C19-YRSm measure onto the EQ-5D-5L

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 11, 2024

Abstract Background Long Covid (LC) is a clinical syndrome of persistent, fluctuating symptoms subsequent to COVID-19 infection with prevalence global estimate many millions cases. LC has significant detrimental effects on health-related quality life (HRQoL), activities daily living (ADL), and work productivity. Condition-specific patient-reported outcome measures (PROMs), such as the modified Covid-19 Yorkshire Rehabilitation Scale (C19-YRSm), have been developed capture impact LC. However, these do not provide health utility data required for cost-utility analyses interventions. The aim this study was therefore derive mapping algorithm C19-YRSm enable utilities be generated from PROM. Methods Data were collected large evaluating services in UK. A total 1434 people had completed both EQ-5D-5L same day. responses then converted EQ-5D-3L scores. Correlation linear regression applied determine items covariates inclusion algorithm. Model fit, mean differences across range scores (−0.59 1), Bland-Altman plots used evaluate Responsiveness (standardised response mean; SRM) mapped also investigated subset participants repeat assessments (N=85). Results There strong level association between 8 2 domains EQ-5D single-item dimensions. These related joint pain, muscle anxiety, depression, walking/moving around, personal care, ADL, social role, well Overall Health Other Symptoms. fit good (R = 0.7). difference actual < 0.10 0 1 indicating degree targeting positive values EQ-5D-3L. SRM (based C19-YRSm) 0.37 compared 0.17 observed scores, suggesting more responsive change. Conclusions We simple, responsive, robust 10 C19-YRSm. This will facilitate economic evaluations interventions, treatment, management LC, further helping describe characterise patients irrespective any treatment

Язык: Английский

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