Journal of Developmental Biology,
Год журнала:
2023,
Номер
11(2), С. 26 - 26
Опубликована: Июнь 6, 2023
Whole
genome
duplication
(WGD)
or
polyploidization
can
occur
at
the
cellular,
tissue,
and
organismal
levels.
At
cellular
level,
tetraploidization
has
been
proposed
as
a
driver
of
aneuploidy
instability
correlates
strongly
with
cancer
progression,
metastasis,
development
drug
resistance.
WGD
is
also
key
developmental
strategy
for
regulating
cell
size,
metabolism,
function.
In
specific
tissues,
involved
in
normal
(e.g.,
organogenesis),
tissue
homeostasis,
wound
healing,
regeneration.
propels
evolutionary
processes
such
adaptation,
speciation,
crop
domestication.
An
essential
to
further
our
understanding
mechanisms
promoting
its
effects
compare
isogenic
strains
that
differ
only
their
ploidy.
Caenorhabditis
elegans
(C.
elegans)
emerging
an
animal
model
these
comparisons,
part
because
relatively
stable
fertile
tetraploid
be
produced
rapidly
from
nearly
any
diploid
strain.
Here,
we
review
use
polyploids
tools
understand
important
sex
determination,
dosage
compensation,
allometric
relationships)
cycle
regulation
chromosome
dynamics
during
meiosis).
We
discuss
how
unique
characteristics
C.
will
enable
significant
advances
role
disease.
Oxford University Press eBooks,
Год журнала:
2024,
Номер
unknown, С. 168 - 190
Опубликована: Фев. 29, 2024
Abstract
Although
the
sizes
of
cells
vary
by
eleven
orders
magnitude
across
Tree
Life,
mean
phenotypes
cellular
traits
commonly
scale
with
cell
volume
in
ways
that
transcend
species
boundaries.
This
is
true,
e.g.,
for
metabolic
rates,
which
increase
statistically
predictable
all
unicellular
organisms.
A
major
goal
evolutionary
biology
to
provide
mechanistic
explanations
such
relationships,
must
be
a
consequence
biophysical
and/or
population-genetic
constraints.
Energetic
costs
construction
and
maintenance
parts
can
summarized
units
numbers
ATP
hydrolyses.
Using
this
approach,
it
found
lifetime
isometrically
volume,
continuously
so
prokaryotes
eukaryotes,
despite
substantial
differences
content
these
groups.
In
contrast,
maximum
rates
division
positively
but
negatively
eukaryotes.
The
upper
limit
growth
rate
close
achievable
based
on
translational
directional
shift
growth-rate
scaling
eukaryotes
may
progressive
reduction
efficiency
natural
selection
growth-enhancing
features
diminished
effective
population
sizes.
asserted
origin
mitochondrion
lead
bioenergetics
revolution
diverse
observations
performance
subcellular
are
inconsistent
hypothesis.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 25, 2024
Under
stable
growth
conditions,
bacteria
maintain
cell
size
homeostasis
through
coordinated
elongation
and
division.
However,
fluctuations
in
nutrient
availability
result
dynamic
regulation
of
the
target
size.
Using
microscopy
imaging
mathematical
modelling,
we
examine
how
bacterial
volume
changes
over
curve
response
to
conditions.
We
find
that
two
rod-shaped
bacteria,
Journal of Cell Science,
Год журнала:
2022,
Номер
135(20)
Опубликована: Окт. 15, 2022
In
April
2022,
The
Company
of
Biologists
hosted
their
first
post-pandemic
in-person
Workshop
at
Buxted
Park
Country
House
in
the
Sussex
countryside.
Workshop,
entitled
'Cell
size
and
growth:
from
single
cells
to
tree
life',
gathered
a
small
group
early-career
senior
researchers
with
expertise
cell
spanning
broad
range
organisms,
including
bacteria,
yeast,
animal
cells,
embryos
plants,
working
fields
biology
ecology
evolutionary
biology.
programme
made
ample
room
for
fruitful
discussions
provided
much-needed
opportunity
discuss
most
recent
findings
relating
regulation
growth,
identify
emerging
challenges
field,
build
community
after
pandemic.
Journal of Developmental Biology,
Год журнала:
2023,
Номер
11(2), С. 26 - 26
Опубликована: Июнь 6, 2023
Whole
genome
duplication
(WGD)
or
polyploidization
can
occur
at
the
cellular,
tissue,
and
organismal
levels.
At
cellular
level,
tetraploidization
has
been
proposed
as
a
driver
of
aneuploidy
instability
correlates
strongly
with
cancer
progression,
metastasis,
development
drug
resistance.
WGD
is
also
key
developmental
strategy
for
regulating
cell
size,
metabolism,
function.
In
specific
tissues,
involved
in
normal
(e.g.,
organogenesis),
tissue
homeostasis,
wound
healing,
regeneration.
propels
evolutionary
processes
such
adaptation,
speciation,
crop
domestication.
An
essential
to
further
our
understanding
mechanisms
promoting
its
effects
compare
isogenic
strains
that
differ
only
their
ploidy.
Caenorhabditis
elegans
(C.
elegans)
emerging
an
animal
model
these
comparisons,
part
because
relatively
stable
fertile
tetraploid
be
produced
rapidly
from
nearly
any
diploid
strain.
Here,
we
review
use
polyploids
tools
understand
important
sex
determination,
dosage
compensation,
allometric
relationships)
cycle
regulation
chromosome
dynamics
during
meiosis).
We
discuss
how
unique
characteristics
C.
will
enable
significant
advances
role
disease.
