Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 19
Опубликована: Ноя. 16, 2022
Acute
ischemic
stroke
is
a
serious
life-threatening
disease
that
affects
almost
600
million
people
each
year
throughout
the
world
with
mortality
of
more
than
10%,
while
two-thirds
survivors
remain
disabled.
However,
available
treatments
for
are
still
limited
to
thrombolysis
and/or
mechanical
thrombectomy,
and
there
an
urgent
need
developing
new
therapeutic
target.
Recently,
intravascular
oxidative
stress,
derived
from
endothelial
cells,
platelets,
leukocytes,
has
been
found
be
tightly
associated
stroke-related
thrombosis.
It
not
only
promotes
primary
thrombus
formation
by
damaging
cells
platelets
but
also
maturation
stability
modifying
fibrin
components.
Thus,
stress
expected
novel
target
prevention
treatment
stroke.
In
this
review,
we
first
discuss
mechanisms
which
thrombosis,
then
summarize
biomarkers
finally
put
forward
antithrombotic
therapy
targeting
in
Processes,
Год журнала:
2022,
Номер
10(10), С. 2031 - 2031
Опубликована: Окт. 8, 2022
Assays
of
total
antioxidant
capacity
(TAC)
are
popular
in
the
analysis
food
products.
This
review
presents
most
assays
TAC
and
their
limitations,
databases
products,
application
clinical
studies,
effect
processing
on
food.
The
importance
sample
preparation
for
striking
effects
digestion
gastrointestinal
tract
discussed.
Critical
opinions
validity
considered.
It
is
concluded
that
methods
can
be
useful
as
screening
quality
control
low-cost,
high-throughput
tools
used
to
discover
potential
sources
follow
changes
content
antioxidants
during
processing.
However,
revealed
by
should
followed
explained
using
more
specific
methods.
Molecules,
Год журнала:
2022,
Номер
27(18), С. 6005 - 6005
Опубликована: Сен. 15, 2022
Carotenoids
are
isoprenoid-derived
natural
products
produced
in
plants,
algae,
fungi,
and
photosynthetic
bacteria.
Most
animals
cannot
synthesize
carotenoids
because
the
biosynthetic
machinery
to
create
de
novo
is
absent
animals,
except
arthropods.
biosynthesized
from
two
C20
geranylgeranyl
pyrophosphate
(GGPP)
molecules
made
isopentenyl
(IPP)
dimethylallyl
(DMAPP)
via
methylerythritol
4-phosphate
(MEP)
route.
can
be
extracted
by
a
variety
of
methods,
including
maceration,
Soxhlet
extraction,
supercritical
fluid
extraction
(SFE),
microwave-assisted
(MAE),
accelerated
solvent
(ASE),
ultrasound-assisted
(UAE),
pulsed
electric
field
(PEF)-assisted
enzyme-assisted
(EAE).
have
been
reported
exert
various
biochemical
actions,
inhibition
Akt/mTOR,
Bcl-2,
SAPK/JNK,
JAK/STAT,
MAPK,
Nrf2/Keap1,
NF-κB
signaling
pathways
ability
increase
cholesterol
efflux
HDL.
absorbed
intestine.
A
handful
carotenoid-based
compounds
clinical
trials,
while
some
currently
used
as
medicines.
The
application
metabolic
engineering
techniques
for
carotenoid
production,
whole-genome
sequencing,
use
plants
cell
factories
produce
specialty
presents
promising
future
research.
In
this
review,
we
discussed
biosynthesis
carotenoids,
roles
human
health,
metabolism
source
drugs
supplements.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Май 4, 2022
The
potential
beneficial
effect
of
individual
antioxidants
on
mortality
has
been
reported.
However,
the
association
overall
intakes
dietary
with
all-cause
and
cause-specific
among
adults
diabetes
remained
unclear.A
total
4,699
US
were
enrolled
in
2003-2014
National
Health
Nutrition
Examination
Survey
(NHANES)
followed
for
until
31
December
2015.
Dietary
Antioxidant
Quality
Score
(DAQS)
Index
(DAI),
which
indicate
antioxidant
properties,
calculated
based
vitamins
A,
C,
E,
zinc,
selenium,
magnesium.
Cox
proportional
hazards
regression
models
used
to
investigate
associations
DAQS
or
DAI
mortality.A
913
deaths
occurred
during
27,735
person-years
follow-up,
including
215
due
cardiovascular
disease
(CVD)
173
cancer.
higher
magnesium,
selenium
associated
lower
mortality.
adjusted
hazard
ratios
(HRs)
(95%
CIs)
comparing
highest
(5-6)
lowest
(0-2)
0.70
(0.53-0.92)
mortality,
0.56
(0.35-0.90)
CVD
0.59
(0.33-1.04)
cancer
Consistent
inverse
found
between
mortality.Higher
intake
was
risk
death
from
diabetes.
Future
intervention
studies
are
needed
determine
whether
increasing
micronutrients
could
prevent
premature
Antioxidants,
Год журнала:
2023,
Номер
12(9), С. 1740 - 1740
Опубликована: Сен. 8, 2023
The
relationship
between
composite
dietary
antioxidant
index
(CDAI)
levels
and
the
risk
of
atherosclerotic
cardiovascular
disease
(ASCVD)
in
postmenopausal
women
is
unknown.
In
total,
3109
from
National
Health
Nutrition
Examination
Survey
2013-2018
were
included
this
cross-sectional
study.
We
evaluated
association
CDAI
ASCVD
by
using
three
logistic
regression
models
restricted
cubic
splines.
A
stratified
analysis
sensitivity
also
conducted.
splines
exhibited
an
L-shaped
dose-response
risk.
Logistic
found
that
negatively
associated
with
occurrence
ASCVD.
ORs
a
per-SD
increase
0.67
(95%
CI:
0.51-0.88)
for
Similarly,
group
high
less
likely
to
have
(OR
=
0.71,
95%
0.50-0.98)
compared
those
low
levels.
When
divided
into
quartiles,
it
was
Q2
(-1.04-1.11),
Q3
(1.11-3.72),
Q4
(3.72-43.87)
0.63
(0.44,
0.90),
0.64
(0.42,
0.94),
0.51
(0.27,
0.97),
respectively,
Q1
(-6.83--1.04).
addition,
age,
high-density
lipoprotein
cholesterol
levels,
smoking
behaviors
acted
as
potential
modifiers,
more
significant
aged
40-69
years,
individuals
smokers
(p
interaction
<0.05).
These
findings
may
offer
valuable
insights
role
development
among
women.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 19
Опубликована: Ноя. 16, 2022
Acute
ischemic
stroke
is
a
serious
life-threatening
disease
that
affects
almost
600
million
people
each
year
throughout
the
world
with
mortality
of
more
than
10%,
while
two-thirds
survivors
remain
disabled.
However,
available
treatments
for
are
still
limited
to
thrombolysis
and/or
mechanical
thrombectomy,
and
there
an
urgent
need
developing
new
therapeutic
target.
Recently,
intravascular
oxidative
stress,
derived
from
endothelial
cells,
platelets,
leukocytes,
has
been
found
be
tightly
associated
stroke-related
thrombosis.
It
not
only
promotes
primary
thrombus
formation
by
damaging
cells
platelets
but
also
maturation
stability
modifying
fibrin
components.
Thus,
stress
expected
novel
target
prevention
treatment
stroke.
In
this
review,
we
first
discuss
mechanisms
which
thrombosis,
then
summarize
biomarkers
finally
put
forward
antithrombotic
therapy
targeting
in
