The role of long non-coding RNA LINC00839 in oral squamous cell carcinoma based on bioinformatics and experimental research DOI Creative Commons
Ashkan Kalantary‐Charvadeh, Saman Morovat, Somayeh Aslani

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 30, 2024

This study explores the role of LINC00839 and its potential interaction with miR-195-5p/cyclin E1 (CCNE1) axis in oral squamous cell carcinoma (OSCC). Using The Cancer Genome Atlas, we analyzed lncRNA, miRNA, mRNA sequencing data for OSCC. Different online tools were applied to detect lncRNA-related miRNAs their target mRNAs, forming a lncRNA/miRNA/mRNA axis. Co-expression analysis determined correlation between lncRNA expression. Afterward, protein-protein network functional enrichment analyses disclosed biological activity genes. expression correlations LINC00839, miR-195-5p, CCNE1 examined 30 pairs OSCC noncancerous tissues. A Chi-square test was used determine clinicopathological associations, ROC estimated diagnostic value. total 66 differentially expressed lncRNAs, 80 miRNAs, 1149 mRNAs identified versus non-tumor samples. After filtering lncRNAs based on novelty, predicting lncRNA-miRNA, miRNA-mRNA interactions, LINC00839/miR-195-5p/CCNE1 discovered. RT-qPCR showed upregulation accompanied by downregulation miR-195-5p. significant positive observed expression, along negative miR-195-5p Moreover, increased associated tumor grade lymph node status, while decreased correlated lymph, depth, vascular invasion (p < 0.05). combined curve demonstrated area under 0.93. discovery reveals novel regulatory mechanism underlying tumorigenesis may provide effective diagnosis therapeutic targets cure this devastating cancer.

Язык: Английский

A prognostic model for head and neck squamous cell carcinoma based on a ceRNA network to predict radiotherapy response DOI

Weixia Liu,

Yuening Zhang,

Yuan Yang

и другие.

Journal of Radiation Research and Applied Sciences, Год журнала: 2025, Номер 18(2), С. 101501 - 101501

Опубликована: Апрель 19, 2025

Язык: Английский

Процитировано

0
The role of long non-coding RNA LINC00839 in oral squamous cell carcinoma based on bioinformatics and experimental research DOI Creative Commons
Ashkan Kalantary‐Charvadeh, Saman Morovat, Somayeh Aslani

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 30, 2024

This study explores the role of LINC00839 and its potential interaction with miR-195-5p/cyclin E1 (CCNE1) axis in oral squamous cell carcinoma (OSCC). Using The Cancer Genome Atlas, we analyzed lncRNA, miRNA, mRNA sequencing data for OSCC. Different online tools were applied to detect lncRNA-related miRNAs their target mRNAs, forming a lncRNA/miRNA/mRNA axis. Co-expression analysis determined correlation between lncRNA expression. Afterward, protein-protein network functional enrichment analyses disclosed biological activity genes. expression correlations LINC00839, miR-195-5p, CCNE1 examined 30 pairs OSCC noncancerous tissues. A Chi-square test was used determine clinicopathological associations, ROC estimated diagnostic value. total 66 differentially expressed lncRNAs, 80 miRNAs, 1149 mRNAs identified versus non-tumor samples. After filtering lncRNAs based on novelty, predicting lncRNA-miRNA, miRNA-mRNA interactions, LINC00839/miR-195-5p/CCNE1 discovered. RT-qPCR showed upregulation accompanied by downregulation miR-195-5p. significant positive observed expression, along negative miR-195-5p Moreover, increased associated tumor grade lymph node status, while decreased correlated lymph, depth, vascular invasion (p < 0.05). combined curve demonstrated area under 0.93. discovery reveals novel regulatory mechanism underlying tumorigenesis may provide effective diagnosis therapeutic targets cure this devastating cancer.

Язык: Английский

Процитировано

0