Immunoregulatory effects of traditional Chinese medicine and its ingredients on psoriasis
International Immunopharmacology,
Год журнала:
2025,
Номер
159, С. 114896 - 114896
Опубликована: Май 22, 2025
Язык: Английский
Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 22, 2025
Age-related
macular
degeneration
(AMD)
is
a
prevalent
neuroinflammation
condition
and
the
leading
cause
of
irreversible
blindness
among
elderly
population.
Smoking
significantly
increases
AMD
risk,
yet
mechanisms
remain
unclear.
Here,
we
investigate
role
Sema4D-PlexinB1
axis
in
progression
AMD,
which
highly
activated
by
smoking.
Using
patient-derived
samples
mouse
models,
discover
that
smoking
presence
Sema4D
on
surface
CD8+
T
cells
migrate
into
choroidal
neovascularization
(CNV)
lesion
via
CXCL12-CXCR4
interact
with
its
receptor
PlexinB1
pericytes.
This
leads
to
ROR2-mediated
phosphorylation
pericyte
activation,
thereby
disrupting
vascular
homeostasis
promoting
neovascularization.
Inhibition
reduces
CNV
improves
benefit
anti-VEGF
treatment.
In
conclusion,
this
study
unveils
molecular
through
exacerbates
pathology,
presents
potential
therapeutic
strategy
targeting
augment
current
treatments.
shows
worsens
neovascular
age-related
pathway.
Targeting
enhances
therapy
efficacy,
offering
approach.
Язык: Английский
Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis
Pharmaceutics,
Год журнала:
2025,
Номер
17(1), С. 51 - 51
Опубликована: Янв. 2, 2025
Psoriasis
is
a
chronic,
recurrent
and
inflammatory
skin
disease.
Although
conventional
immunosuppressants
can
ameliorate
psoriatic
symptoms,
it
tends
to
relapse
over
time.
Previous
studies
have
shown
that
exosomes
from
both
immune
non-immune
cells
participate
in
immunopathology.
The
biologically
active
cargoes
accelerate
psoriasis
progression
by
altering
gene
profiles
signaling
pathways
of
neighboring
cells.
On
the
other
hand,
be
utilized
as
drug
delivery
platforms
for
treatment.
Especially,
engineered
may
serve
systems
effective
proteins,
nucleic
acids
or
drugs
due
their
low
immunogenicity,
good
stability
ability
fuse
with
target
Therefore,
investigation
into
mechanisms
underlying
intercellular
communications
mediated
lesions
likely
helps
design
therapy
psoriasis.
In
this
review,
we
summarized
recent
advances
biogenesis
potential
roles
pathogenesis
treatment
further
discussed
challenges
future
directions
particular,
review
highlights
immunoregulatory
function
derived
exosome-based
therapeutic
applications
psoriasis,
including
systems.
Thus,
help
Язык: Английский
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression
Acta Pharmaceutica Sinica B,
Год журнала:
2025,
Номер
15(2), С. 876 - 891
Опубликована: Янв. 5, 2025
Psoriasis
is
an
incurable
chronic
inflammatory
disease
that
requires
new
interventions.
Here,
we
found
fibroblasts
exacerbate
psoriasis
progression
by
promoting
macrophage
recruitment
via
CCL2
secretion
single-cell
multi-omics
analysis.
The
natural
small
molecule
celastrol
was
screened
to
interfere
with
the
of
and
improve
psoriasis-like
symptoms
in
both
murine
cynomolgus
monkey
models.
Mechanistically,
directly
bound
low-density
lipoprotein
receptor-related
protein
1
(LRP1)
β-chain
abolished
its
binding
transcription
factor
c-Jun
nucleus,
which
turn
inhibited
production
skin
fibroblasts,
blocked
fibroblast-macrophage
crosstalk,
ameliorated
progression.
Notably,
fibroblast-specific
LRP1
knockout
mice
exhibited
a
significant
reduction
like
inflammation.
Taken
together,
from
clinical
samples
combined
various
mouse
models,
revealed
pathogenesis
perspective
provided
foundation
for
as
novel
potential
target
treatment.
Язык: Английский
The Critical Role and Therapeutic Potential of the CXCR Family in Skin Diseases
Jin Xu,
Chaoyi Wang,
Yundong Xu
и другие.
Frontiers in Bioscience-Landmark,
Год журнала:
2025,
Номер
30(5)
Опубликована: Апрель 29, 2025
The
C-X-C
chemokine
receptors
(CXCR)
receptor
family,
consisting
of
seven
primary
members
(CXCR1-CXCR7),
is
crucial
in
regulating
immune
cell
recruitment,
angiogenesis,
cellular
proliferation,
and
maintaining
skin
homeostasis
functions.
This
review
evaluates
the
expression
roles
CXCR
across
a
range
cells,
including
keratinocytes,
fibroblasts,
endothelial
melanocytes,
various
cells
such
as
T
dendritic
macrophages.
Aberrations
signaling
have
been
associated
with
variety
disorders,
psoriasis,
atopic
dermatitis,
acne,
cancers.
Despite
significant
advancements
field,
several
critical
questions
persist.
These
include
differential
effects
distinct
pathologies
intricate
interactions
between
their
ligands
within
diverse
microenvironments.
Moreover,
therapeutic
targeting
family
remains
unresolved,
necessitating
further
research
into
its
long-term
efficacy
possible
adverse
effects.
Future
investigations
should
prioritize
these
issues
to
develop
more
effective
strategies
for
managing
diseases,
ultimately
improving
patient
outcomes.
Язык: Английский
Exploring the Common Pathogenic Mechanisms of Psoriasis and Atopic Dermatitis: The Interaction between SGK1 and TIGIT Signaling Pathways
Inflammation,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
Язык: Английский
Multitranscriptome analysis revealed that stromal cells in the papillary dermis promote angiogenesis in psoriasis vulgaris
British Journal of Dermatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Abstract
Background
The
pathogenesis
of
psoriasis
is
incompletely
understood.
Growing
evidence
suggests
the
involvement
stromal
cells
in
inflammatory
process.
Objectives
To
investigate
roles
cells,
including
fibroblasts,
vascular
endothelial
(VECs)
and
smooth
muscle
(VSMCs),
psoriatic
microenvironment,
possible
underlying
mechanisms
involved.
Methods
We
used
a
combination
single-cell,
spatial
transcriptome
bulk
RNA
sequencing
lesional
nonlesional
skin
samples
from
patients
with
vulgaris
(PV)
healthy
unaffected
individuals.
Results
By
analysing
transcriptomes
364
098
single
we
uncovered
WNT5A+
(Wnt-5a)
ITIH5+
(inter-α-trypsin
inhibitor
heavy
chain
5)
VECs
VCAN+
(versican)
VSMCs,
significantly
increased
proportions
these
papillary
dermis
skin.
defined
eight
unique
subclusters
fibroblasts
observed
shift
WIF1+
(Wnt
inhibitory
factor
1)
toward
abnormal
activation
noncanonical
Wnt
signalling
pathway
angiogenic
proinflammatory
capabilities.
VSMCs
were
able
to
undergo
phenotypic
transformation
contractile
synthetic
phenotype
during
development
inflammation.
found
have
an
essential
role
regulating
angiogenesis
remodelling
pathological
changes
seen
PV.
Ligand
receptor
analyses
that
are
extensively
implicated
interactions
various
cell
types,
especially
TIH5+
dermis.
Conclusions
Interactions
identified
as
pathogenic
elements
Improving
microenvironment
by
targeting
might
be
potential
treatment
strategy
Язык: Английский