Journal of Pediatric Neuropsychology, Год журнала: 2023, Номер 10(1), С. 30 - 48
Опубликована: Окт. 26, 2023
Язык: Английский
BMC Public Health, Год журнала: 2024, Номер 24(1)
Опубликована: Окт. 15, 2024
The post COVID-19 health condition of Chinese residents infected with Omicron is not clear after the change epidemic prevention policies. This study aimed to clarify epidemiology and associated factors about status rehabilitation patients.
Язык: Английский
Процитировано
0
Acta Médica Portuguesa, Год журнала: 2023, Номер 36(12), С. 811 - 818
Опубликована: Дек. 4, 2023
Mental health warrants exist in most countries and are issued when patients have severe mental illness, refuse treatment, present a serious risk to themselves or others. We describe the epidemiology of warrant requests received, by Public Health Unit Portuguese region, as well subsequent hospital admissions before during COVID-19 pandemic.We used routine administrative data request entries from serving population 219 739 individuals compared average monthly requests, warrants, two separate periods (January 2013 January 2021 February October 2022) proportion issued, among other patient characteristics. identified factors associated with using logistic regression.Monthly increased after (x̄ 2.87 vs 7.09 p < 0.001; x̄ 2.67 6.42 1.55 3.58 0.001). found no differences period (92.8% 90.6% = 0.42) nor (54.0% 49.0% 0.33). In second period, there were previously diagnosed disorder (95.3% 90.4% 0.049). There significant distribution origin requests. Being unemployed (OR:2.5 CI:1.2 - 5.2), not having completed high school (OR:2.01 CI:1.12 3.77) university education (OR:3.67 CI:1.27 10.57) degree admission.Severe illness criteria for may require more resources different approaches due possible increase pandemic. Community based healthcare, incentivized follow-up primary care ambulatory treatment be considered. Further research should evaluate both national international trends factors.
Язык: Английский
Процитировано
1
Cureus, Год журнала: 2023, Номер unknown
Опубликована: Дек. 25, 2023
Coronavirus disease 2019 (COVID-19) is associated with long-term neuropsychiatric sequelae. We describe a 60-year-old male patient's history and symptom trajectory encompassing the development of behavioral symptoms cognitive deficits following pneumonia subsequent autoimmune encephalitis COVID-19. also changes in these facets correlative his immunological parameters after both acute intravenous immunoglobulin (IVIG) therapy chronic periodic IVIG every two weeks over course years. We review literature on treatment long COVID-19 spanning domains. In addition, we elucidate current role infusions for using our presentation improvement as an illustrative example.
Язык: Английский
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Июль 13, 2023
Abstract Background Long COVID is a debilitating chronic condition that has affected over 100 million people globally. It characterized by diverse array of symptoms, including fatigue, cognitive dysfunction and respiratory problems. Studies have so far largely failed to identify genetic associations, the mechanisms behind disease, or any common pathophysiology with other conditions such as ME/CFS present similar symptoms. Methods We used combinatorial analysis approach combinations variants significantly associated development long examine biological underpinning its various compared two subpopulations patients from Sano Genetics’ GOLD study cohort, focusing on severe fatigue dominant phenotypes. evaluated signatures previously identified in an population against this understand similarities disorders may be triggered prior viral infection. Finally, we also output known associations diseases, range metabolic neurological disorders, overlap pathophysiological mechanisms. Results Combinatorial 73 genes were highly at least one populations included analysis. Of these, 9 acute COVID-19, 14 differentially expressed transcriptomic patients. A pathway enrichment revealed pathways most mainly aligned cardiometabolic diseases. Expanded genotype suggests specific SNX9 genotypes are significant contributor risk protection infection, but gene-disease relationship context dependent mediated interactions KLF15 RYR3 . Comparison uniquely Severe Fatigue Dominant differences between enriched each subgroup. The unique immune myeloid differentiation macrophage foam cells. Genes subgroup MAPK/JNK signaling. ME/CFS, several involved circadian rhythm regulation insulin regulation. Overall, 39 SNPs can linked recent patient UK Biobank. Among COVID, 42 potentially tractable for novel drug discovery approaches, 13 these already targeted drugs clinical pipelines. From example, TLR4 antagonists repurposing candidates potential protect term impairment pathology caused SARS-CoV-2. currently evaluating targets use treating and/or ME/CFS. Conclusion This demonstrates power analytics stratifying heterogeneous complex diseases do not simple monogenic etiologies. These results build upon findings analyses COVID-19 expect access additional independent, larger datasets will further improve disease insights validate treatment options COVID.
Язык: Английский
Процитировано
0
Journal of Pediatric Neuropsychology, Год журнала: 2023, Номер 10(1), С. 30 - 48
Опубликована: Окт. 26, 2023
Язык: Английский
Процитировано
0