Cardiovascular Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 31, 2024
Abstract
The
improvements
in
imaging
technology
opened
up
the
possibility
to
investigate
structure
and
function
of
cerebral
vasculature
neurovascular
unit
with
unprecedented
precision
gaining
deep
insights
not
only
on
morphology
vessels
but
also
regarding
their
regulation
related
activity.
In
this
review,
we
will
dissect
different
capabilities
cerebrovascular
tree,
unit,
haemodynamic
response
function,
thus,
vascular–neuronal
coupling.
We
discuss
both
clinical
preclinical
setting,
a
final
discussion
current
scenery
where
magnetic
resonance
multimodal
microscopy
emerge
as
most
potent
versatile
tools,
respectively,
context.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 23, 2023
AbstractBackground:
Reactive
astrocytes
play
important
roles
in
the
development
of
Alzheimer’s
disease
(AD)
and
primary
tauopathies.
Here,
we
aim
to
investigate
relationship
between
reactive
astrocytes,
tau
amyloid
beta,
microgliosis
glucose
metabolism
by
using
multitracer
imaging
widely
used
tauopathy
familial
AD
mouse
models.
Results:
Positron
emission
tomography
(PET)
[18F]SMBT-1
(monoamine
oxidase-B),
[18F]florbetapir
(amyloid-beta),
[18F]PM-PBB3
(tau),
[18F]DPA-714
(translocator
protein)
[18F]fluorodeoxyglucose
(FDG)
was
carried
out
3-
7-month-old
rTg4510
mice,
5×FAD
mice
aged-matched
wild-type
mice.
We
found
increased
regional
[18F]SMBT-1,
uptake,
hypoglucose
brains
with
accumulation
as
well
higher
amyloid-beta
compared
age-matched
Conclusion:
In
summary,
these
findings
provide
in-vivo
evidence
for
microglial
activation,
cerebral
animal
models
AD.
Clinical and Translational Medicine,
Год журнала:
2024,
Номер
14(4)
Опубликована: Апрель 1, 2024
Diagnostic
and
therapeutic
potential
of
tonic
gamma-aminobutyric
acid
from
reactive
astrocytes
in
brain
diseasesDear
Editor,
Gamma-aminobutyric
(GABA),
the
primary
inhibitory
neurotransmitter
brain,
serves
as
a
cornerstone
modulating
neuronal
activity
maintaining
cognitive
functions.Its
role
extends
beyond
fast-acting
phasic
inhibition,
slow-acting
GABA
mediated
by
extrasynaptic
A
receptors,
responds
to
ambient
levels
(i.e.GABA
tone),
significantly
influencing
synaptic
plasticity,
learning
memory,
sensory
processing.
1
Dysregulation
inhibition
range
neurological
psychiatric
diseases
is
associated
with
decline,
motor
symptoms,
other
functional
impairments,
highlighting
potentially
broad
impact
tone
across
various
diseases.One
common
cellular
responses
pathological
conditions
emergence
astrocytes,
2
often
accompanied
upregulation
monoamine
oxidase
B
(MAO-B)
expression
increased
synthesis
(Figure
1A),
thus
affecting
neighbouring
neurons
through
inhibition.
3Here,
we
present
propose
its
diagnostic
targets
for
clinical
applications.Astrocytes
once
thought
be
mere
support
cells,
emerge
key
players
regulation
mechanisms
synthesis,
release,
clearance.
1These
cells
are
strategically
positioned
interface
closely
neurons,
allowing
them
effectively
regulate
space.This
becomes
particularly
crucial
conditions,
such
Alzheimer's
3-5
Parkinson's
diseases.
6,7n
these
become
reactive,
exhibiting
MAO-B
enhanced
which
contributes
an
elevated
leads
symptoms.This
phenomenon
not
limited
disease
but
also
observed
stroke,
8
depression,
9
obesity,
10
like
post-traumatic
stress
disorder
Cardiovascular Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 31, 2024
Abstract
The
improvements
in
imaging
technology
opened
up
the
possibility
to
investigate
structure
and
function
of
cerebral
vasculature
neurovascular
unit
with
unprecedented
precision
gaining
deep
insights
not
only
on
morphology
vessels
but
also
regarding
their
regulation
related
activity.
In
this
review,
we
will
dissect
different
capabilities
cerebrovascular
tree,
unit,
haemodynamic
response
function,
thus,
vascular–neuronal
coupling.
We
discuss
both
clinical
preclinical
setting,
a
final
discussion
current
scenery
where
magnetic
resonance
multimodal
microscopy
emerge
as
most
potent
versatile
tools,
respectively,
context.
