Опубликована: Дек. 1, 2024
Язык: Английский
Trends in Neurosciences, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Апрель 5, 2025
1People differ widely in how they make decisions uncertain environments. While many studies leverage this variability to measure differences specific cognitive processes and parameters, the key dimension(s) of individual decision-making tasks has not been identified. Here, we analyzed behavioral data from 1001 participants performing a restless three-armed bandit task, where reward probabilities fluctuated unpredictably over time. Using novel analytical approach that controlled for stochasticity tasks, identified dominant nonlinear axis variability. We found primary was strongly selectively correlated with probability exploration, as inferred by latent state modeling. This suggests major factor shaping task performance is tendency explore (versus exploit), rather than personality characteristics, reinforcement learning model or low-level strategies. Certain demographic characteristics also predicted variance along principle axis: at exploratory end tended be younger exploitative end, self-identified men were overrepresented both extremes. Together, these findings offer principled framework understanding behavior while highlighting factors shape under uncertainty.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Май 10, 2024
Abstract Willingness to exert effort for a given goal is dependent on the magnitude of potential rewards and costs an action. Such effort-based decision making essential component motivation, in which dopaminergic system plays key role. Depression Parkinson’s disease (PD) common, disabling has poor outcomes. Motivational symptoms such as apathy anhedonia, are prominent PD depression related loss. We hypothesised that dopamine-dependent disruption decision-making contributes PD. In present study, task was administered 62 patients with PD, without depression, ON OFF their medication across two sessions, well 34 29 matched controls single occasion. During task, each trial, participants decided whether accept or reject offers different levels monetary reward return exerting varying physical via grip force, measured using individually calibrated dynamometers. The primary outcome variable choice (accept/decline offer), analysed both logistic mixed-effects modelling computational model dissected individual contributions dopamine state found characterised by lower acceptance offers, driven markedly incentivisation (reward sensitivity), compared all other groups. Within-subjects analysis effect revealed that, although treatment improves sensitivity non-depressed patients, this therapeutic not depression. These findings suggest disrupted decision-making, unresponsive dopamine, This highlights mechanism target potentially requires non-dopaminergic therapies.
Язык: Английский
Процитировано
2
Parkinsonism & Related Disorders, Год журнала: 2024, Номер 128, С. 107127 - 107127
Опубликована: Сен. 17, 2024
Язык: Английский
Процитировано
2
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Окт. 11, 2024
SUMMARY Apathy is a syndrome characterized by disruption in effort-reward decision-making, accompanied structural and functional changes related fronto-basal ganglia (BG) network. While activity the primary motor cortex (M1) during effort reward valuation have been repeatedly observed, previous work on apathy has largely overlooked connections between fronto-BG network M1, potentially missing key circuits This study addresses this gap investigating effective connectivity fronto-M1, fronto-BG-M1, intra-M1 relation to subclinical 45 healthy subjects. Behavior was assessed using battery of apathy-related questionnaires computational modeling decision-making task. Fronto-motor were examined through combination MRI-derived tractography paired-pulse transcranial magnetic stimulation, which probed connectivity, respectively. The data reveal that scores are associated with both fronto-M1 fronto-BG-M1 circuits. Circuits originating from supplementary area primarily index valuation, while GABAergic correlates exclusively valuation. These findings suggest distinct fronto-motor linked different dimensions motivated behavior may constitute specific neuromodulation targets for patients suffering apathy.
Язык: Английский
Процитировано
2
Frontiers in Neurology, Год журнала: 2024, Номер 15
Опубликована: Сен. 25, 2024
Gender differences in the access to advanced therapies for Parkinson's disease (PD) are poorly investigated.
Язык: Английский
Процитировано
1
Journal of Neural Transmission, Год журнала: 2024, Номер 132(2), С. 169 - 201
Опубликована: Окт. 25, 2024
Язык: Английский
Процитировано
1
Brain, Год журнала: 2024, Номер 147(4), С. 1127 - 1129
Опубликована: Март 26, 2024
This scientific commentary refers to ‘Impaired value-based decision-making in Parkinson’s disease apathy’ by Gilmour et al. (https://doi.org/10.1093/brain/awae025).
Язык: Английский
Процитировано
0
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0