Comparison of MIBG uptake in the major salivary glands between Lewy body disease and progressive supranuclear palsy DOI Creative Commons
Junya Ebina,

Sunao Mizumura,

Mari Shibukawa

и другие.

Clinical Parkinsonism & Related Disorders, Год журнала: 2024, Номер 11, С. 100287 - 100287

Опубликована: Янв. 1, 2024

Cardiac sympathetic denervation is specific to Lewy body disease (LBD). In Parkinson's (PD), in the major salivary glands (parotid [PG] and submandibular [SMG]) has been demonstrated by 123I-metaiodobenzylguanidine (MIBG) scintigraphy. We compared MSG between PD, dementia with bodies (DLB), progressive supranuclear palsy (PSP). recruited 81 patients 12 DLB, 13 PSP 25 control subjects. evaluated MIBG uptake heart using a quantitative semi-automatic method. controls, we sensitivity specificity. olfactory function PD patients. PG SMG delayed phase was significantly lower DLB than controls. Conversely, comparable DLB. Between LBD non-LBD, showed 56-100 % specificity PG, while it had 55.6-87.5 SMG. PSP, higher function, of function. patients, especially phase. may differentiate from hyposmic PSP.

Язык: Английский

Remote Cortical Network for Frontal Cognitive Symptoms derived from Tau Accumulation in Progressive Supranuclear Palsy DOI Creative Commons
Yuki Hori,

Hironobu Endo,

Kenji Tagai

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Abstract Progressive Supranuclear Palsy (PSP) is a neurodegenerative disorder characterized by movement impairments and frontal cognitive dysfunctions. While motor symptoms are linked with subcortical tau deposits, mechanisms underlying the remain unclear due to limited accumulation in cortex heterogeneous distribution. Here, we combined high-contrast PET normative connectome identify common network extended from deposits PSP. Regions deposition were connected cortical that was not detectable through atrophy-based analyses. This primarily overlapped canonical action-mode frontoparietal networks. degree of or atrophy correlated symptoms, only connectivity between sites derived explained deficits. These findings propose PSP, emphasizing role for remote effects pathological deposits.

Язык: Английский

Процитировано

0
Pathomechanisms of neuropsychiatric disturbances in atypical parkinsonian disorders: a current view DOI
K. A. Jellinger

Journal of Neural Transmission, Год журнала: 2025, Номер unknown

Опубликована: Фев. 15, 2025

Язык: Английский

Процитировано

0
Relationships Between Glymphatic System Activity and Tau Burden, Dopaminergic Impairment, Abnormal Glucose Metabolism in Progressive Supranuclear Palsy DOI Creative Commons
Fangyang Jiao, Qingmin Wang,

Jiayi Zhong

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background Progressive supranuclear palsy (PSP) is a primary tauopathy characterized by dopaminergic impairment and abnormal glucose metabolism. The glymphatic system can promote the elimination of tau protein. association between function pathological hallmark in neuroimaging remains unknown. Methods Diffusion tensor imaging (DTI) positron emission tomography (PET) scanning with 18 F‐Florzolotau, F‐FPCIT, F‐FDG were performed PSP patients. DTI analysis along perivascular space (ALPS) index was computed to assess function, while semi‐quantitative value employed measure burden impairment. PSP‐related pattern (PSPRP) served as an indicator metabolic brain network activity. Results patients exhibited changes ALPS deposition. index, deposition, PSPRP expression showed significant correlations clinical scores. Additionally, correlated deposition expression. However, neither nor scores striatum dysfunction. Finally, subcortical regions mediating effects Conclusion dysfunction associated activity independent PSP.

Язык: Английский

Процитировано

0
Imaging biomarkers for the diagnosis of corticobasal ganglia syndrome: DaTSCAN and [18F]FDG PET DOI Creative Commons
Elena Missir,

Mona Cornwell

NeuroMarkers., Год журнала: 2025, Номер 2(3), С. 100079 - 100079

Опубликована: Апрель 3, 2025

Язык: Английский

Процитировано

0
Anti-IgLON5 Disease 10 Years Later DOI Creative Commons
Francesc Graus, Lídia Sabater, Carles Gaig

и другие.

Neurology Neuroimmunology & Neuroinflammation, Год журнала: 2024, Номер 12(1)

Опубликована: Дек. 20, 2024

Anti-IgLON5 disease was identified 10 years ago, thanks to the discovery of IgLON5 antibodies and joint effort specialists in sleep medicine, neuroimmunology, neuropathology. Without this collaboration, it would have been impossible untangle fundamental aspects disease. After seminal description 2014, today there is growing evidence that most patients present a chronic progressive course with gait instability, abnormal movements, bulbar dysfunction, disorder characterized by nonrapid eye movement REM parasomnias, obstructive apnea stridor. Unlike other autoimmune encephalitides, response immunotherapy suboptimal. Neuropathologic studies prolonged clinical showed novel 3-repeat 4-repeat neuronal tauopathy mainly involving hypothalamus tegmentum brainstem. The absence tau deposits brain who died early, demonstration cause an irreversible decrease cell-surface levels IgLON5, disorganization cytoskeleton suggest primarily secondary event. decade, we now know much better, but important issues still need be addressed. We gather more information on natural disease, develop better treatments, identify robust predictors outcome. More basic research needed physiology how disrupt its function, downstream effects leading neurodegeneration. Finally, designed passive transfer active immunization models are confirm pathogenic effect antibodies.

Язык: Английский

Процитировано

2
Alzheimer’s Disease-Related Cerebrospinal Fluid Biomarkers in Progressive Supranuclear Palsy DOI Creative Commons
Takanobu Ishiguro, Kensaku Kasuga

Brain Sciences, Год журнала: 2024, Номер 14(9), С. 859 - 859

Опубликована: Авг. 26, 2024

Progressive Supranuclear Palsy (PSP) is the most common four-repeat tauopathy. PSP cases are typically characterized by vertical gaze palsy and postural instability; however, various phenotypes have been reported, making antemortem diagnosis based on clinical symptoms challenging. The development of biomarkers reflecting brain pathology ability to diagnose patients these essential for developing future intervention strategies, including disease-modifying therapies. However, despite many dedicated efforts, no highly specific fluid biomarker has yet established. Conversely, several cerebrospinal (CSF) Alzheimer’s Disease (AD) established, an AT(N) classification system proposed. Typically, among with AD, CSF amyloid β42 (Aβ42), but not Aβ40, decreased, resulting in a reduction Aβ42/Aβ40 ratio, while tau phosphorylated at threonine 181 (p-tau181) total (t-tau) increased. Interestingly, core AD show unique patterns PSP. Furthermore, reports indicated that levels both Aβ42 Aβ40 decreased independently Aβ accumulation Therefore, ratio could potentially be used differentiate from AD. Additionally, studies reported p-tau t-tau reduced PSP, neurofilament light chain remarkably increased compared healthy controls even though neurodegenerative disease associated accumulation. These PSP-specific changes AD-related may reflect contribute its diagnosis. As such, elucidating mechanisms underlying observed decreases facilitate better understanding pathogenesis

Язык: Английский

Процитировано

1
Comparison of MIBG uptake in the major salivary glands between Lewy body disease and progressive supranuclear palsy DOI Creative Commons
Junya Ebina,

Sunao Mizumura,

Mari Shibukawa

и другие.

Clinical Parkinsonism & Related Disorders, Год журнала: 2024, Номер 11, С. 100287 - 100287

Опубликована: Янв. 1, 2024

Cardiac sympathetic denervation is specific to Lewy body disease (LBD). In Parkinson's (PD), in the major salivary glands (parotid [PG] and submandibular [SMG]) has been demonstrated by 123I-metaiodobenzylguanidine (MIBG) scintigraphy. We compared MSG between PD, dementia with bodies (DLB), progressive supranuclear palsy (PSP). recruited 81 patients 12 DLB, 13 PSP 25 control subjects. evaluated MIBG uptake heart using a quantitative semi-automatic method. controls, we sensitivity specificity. olfactory function PD patients. PG SMG delayed phase was significantly lower DLB than controls. Conversely, comparable DLB. Between LBD non-LBD, showed 56-100 % specificity PG, while it had 55.6-87.5 SMG. PSP, higher function, of function. patients, especially phase. may differentiate from hyposmic PSP.

Язык: Английский

Процитировано

0