Abnormal dynamic functional connectivity is linked to recovery after acute ischemic stroke

Human Brain Mapping, Год журнала: 2021, Номер 42(7), С. 2278 - 2291

Опубликована: Март 2, 2021

The aim of the current study was to explore whole-brain dynamic functional connectivity patterns in acute ischemic stroke (AIS) patients and their relation short long-term severity. We investigated resting-state MRI-based 41 AIS two five days after symptom onset. Re-occurring configurations were obtained using a sliding window approach k-means clustering. evaluated differences between three NIHSS-stroke severity defined groups (mildly, moderately, severely affected patients). Furthermore, we built Bayesian hierarchical models evaluate predictive capacity examine interrelation with clinical measures, such as white matter hyperintensity lesions. Finally, established correlation analyses well 90-day neurological recovery (ΔNIHSS). identified distinct acutely post-stroke. More spent significantly more time configuration that characterized by particularly strong isolated processing brain domains (three-level ANOVA: p < .05, post hoc t tests: FDR-corrected). Configuration-specific estimates possessed addition one measures. Recovery, indexed realized change NIHSS over time, linked bilateral intraparietal lobule left angular gyrus (Pearson's r = -.68, .003, Our findings demonstrate transiently increased information multiple case severe AIS. Dynamic involving default mode network components correlated first 3 months poststroke.

Язык: Английский

---

MRI findings in autoimmune encephalitis

Revue Neurologique, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

---

Functional connectivity dynamics reflect disability and multi-domain clinical impairment in patients with relapsing-remitting multiple sclerosis

NeuroImage Clinical, Год журнала: 2022, Номер 36, С. 103203 - 103203

Опубликована: Янв. 1, 2022

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system associated with deficits in cognitive and motor functioning. While structural brain changes such as demyelination are early hallmark disease, a characteristic profile functional alterations MS lacking. Functional neuroimaging studies at various stages have revealed complex heterogeneous patterns aberrant connectivity (FC) MS, previous largely being limited to static account FC. Thus, it remains unclear how time-resolved FC relates variance clinical disability status MS. We here aimed characterize network organization patients analysis explore relationship between status, multi-domain outcomes altered dynamics. Resting-state MRI (rs-fMRI) data were acquired from 101 age- sex-matched healthy controls (HC). Based on Expanded Disability Status Score (EDSS), split into two sub-groups: without (EDSS≤1, n = 36) mild moderate levels (EDSS≥2, 39). Five dynamic states extracted whole-brain rs-fMRI data. Group differences strength, across-state overall connectivity, dwell time, transition frequency, modularity, global assessed. Patients' impairment was quantified custom outcome z-scores (higher: worse) for domains depressive symptoms, fatigue, motor, vision, cognition, total atrophy, lesion load. Correlation analyses measures performed Spearman partial correlation controlling age. Patients exhibited more widespread spatiotemporal pattern spent time high-connectivity, low-occurrence state compared HCs. Worse symptoms all positively EDSS scores. Furthermore, symptom severity related dynamics measured by state-specific DMN attention networks, while fatigue reduced frontoparietal basal ganglia. Despite comparably low we identified distinct those disability, these sensitive multiple domains. uncovered correlations that remained undetected conventional analyses, showing accounting temporal helps disentangle alterations,

Язык: Английский

---

Impaired functional connectivity of the hippocampus in translational murine models of NMDA-receptor antibody associated neuropsychiatric pathology

Molecular Psychiatry, Год журнала: 2023, Номер 29(1), С. 85 - 96

Опубликована: Окт. 24, 2023

Abstract Decreased hippocampal connectivity and disruption of functional networks are established resting-state MRI (rs-fMRI) features that associated with neuropsychiatric symptom severity in human anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. However, the underlying pathophysiology NMDAR encephalitis remains poorly understood. Application patient-derived monoclonal antibodies against NR1 (GluN1) subunit now allows for translational investigation experimental murine antibody disease models neurodevelopmental disorders. Using rs-fMRI, we studied alterations (1) adult C57BL/6 J mice were intrathecally injected a recombinant over 14 days ( n = 10) (2) newly mouse model utero exposure to (NR1-offspring) at age (2a) 8 weeks 15) (2b) 10 months 14). Adult NR1-antibody showed impaired within left hippocampus compared controls, resembling patterns observed patients. Similarly, NR1-offspring significantly reduced after weeks, was likewise months. We successfully reproduced changes different systems previously Translational application this method combined imaging histopathological framework will allow future studies identify biological mechanisms may eventually facilitate non-invasive monitoring activity treatment responses autoimmune

Язык: Английский

---

Functional connectivity changes of the hippocampal subregions in anti-N-methyl-D-aspartate receptor encephalitis

Brain Imaging and Behavior, Год журнала: 2024, Номер 18(3), С. 686 - 697

Опубликована: Фев. 16, 2024

Язык: Английский

---

Reduced resilience of brain state transitions in anti‐N‐methyl‐D‐aspartate receptor encephalitis

European Journal of Neuroscience, Год журнала: 2022, Номер 57(3), С. 568 - 579

Опубликована: Дек. 14, 2022

Patients with anti-N-methyl-aspartate receptor (NMDA) encephalitis suffer from a severe neuropsychiatric syndrome, yet most patients show no abnormalities in routine magnetic resonance imaging. In contrast, advanced neuroimaging studies have consistently identified disrupted functional connectivity these patients, recent work suggesting increased volatility of state dynamics. Here, we investigate network dynamics through the spatiotemporal trajectory meta-state transitions, yielding time-resolved account brain exploration anti-NMDA encephalitis. To this end, resting-state imaging data were acquired 73 and age- sex-matched healthy controls. Time-resolved was clustered into meta-states, giving rise to transition graph states as nodes transitions between meta-states weighted, directed edges. Network topology, robustness cost networks compared groups. Transition showed significantly lower local efficiency (t = -2.41, pFDR .029), -2.01, .048) higher leap size 2.18, .037) Furthermore, ratio within-to-between module similarity patients. Importantly, alterations correlated disease severity. Together, findings reveal systematic that is characterized by reduced stability resilience plays clinically relevant role manifestation disease.

Язык: Английский

---

The T1-weighted/T2-weighted ratio as a biomarker of anti-NMDA receptor encephalitis

Journal of Neurology Neurosurgery & Psychiatry, Год журнала: 2023, Номер unknown, С. jnnp - 332069

Опубликована: Окт. 5, 2023

Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis rarely causes visible lesions in conventional MRI, yet advanced imaging detects extensive white matter damage. To improve prognostic capabilities, we evaluate the T1-weighted/T2-weighted (T1w/T2w) ratio, a measure of integrity computable from clinical MRI sequences, NMDAR and examine its associations with cognitive impairment. Methods T1-weighted T2-weighted were acquired cross-sectionally at 3 Tesla 53 patients (81% women, mean age 29 years) matched healthy controls. Quantitative voxel-wise group differences T1w/T2w ratios neuropsychological outcomes assessed. P-values false discovery rate (FDR) adjusted where multiple tests conducted. Results Patients had significantly lower across normal appearing (p=0.009, Hedges’ g=−0.51), which was associated worse verbal episodic memory performance (r=0.39, p=0.005, p(FDR)=0.026). White loss observed corticospinal tract, superior longitudinal fascicle, optic radiation callosal body medium to large effects (Cohen’s d=[0.42–1.17]). In addition, showed decreased hippocampus (p=0.002, p(FDR)=0.005, g=−0.62), amygdala g=−0.63) thalamus (p=0.010, p(FDR)=0.019, g=−0.51). Conclusions The ratio microstructural changes grey that correlate performance. Computable this shows promise bridging clinico-radiological dissociation could serve as an outcome trials.

Язык: Английский

---

Hippocampal hub failure is linked to long-term memory impairment in anti-NMDA-receptor encephalitis: insights from structural connectome graph theoretical network analysis

Journal of Neurology, Год журнала: 2024, Номер 271(9), С. 5886 - 5898

Опубликована: Июль 8, 2024

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is characterized by distinct structural and functional brain alterations, predominantly affecting the medial temporal lobes hippocampus. Structural connectome analysis with graph-based investigations of network properties allows for an in-depth characterization global local changes their relationship clinical deficits in NMDAR encephalitis.

Язык: Английский

---

Eigenvector centrality mapping reveals volatility of functional brain dynamics in anti-NMDA receptor encephalitis

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2024, Номер 9(11), С. 1222 - 1229

Опубликована: Июль 27, 2024

Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) causes long-lasting cognitive deficits associated with altered functional connectivity. Eigenvector centrality (EC) mapping represents a powerful new method for data-driven voxel-wise and time-resolved estimation of network importance – beyond changes in classical 'static' To assess brain organization, we applied EC 73 patients NMDARE matched healthy controls. Areas significant group differences were further investigated using (i) spatial clustering analyses, (ii) time series correlation to synchronicity between the hippocampus cortical regions, (iii) clinical parameters. Dynamic, showed significantly higher variability 13 areas (p(FWE)<0.05) compared HC. dynamic spatially organized clusters resembling resting-state networks. Importantly, frontotemporal cluster was impaired verbal episodic memory (r=-0.25, p=0.037). medial prefrontal cortex reduced HC (p(FWE)<0.05, t(max)=3.76), (r=0.28, p=0.019). Static analyses only one region (left intracalcarine cortex). Widespread dynamics hippocampal-medial may thus represent neural correlate dysfunction NMDARE. detected substantially more alterations than traditional static approaches, highlighting potential this explain long-term

Язык: Английский

---

Altered Dynamic Resting State Functional Connectivity Associated With Somatosensory Impairments in the Upper Limb in the Early Sub-Acute Phase Post-Stroke

Neurorehabilitation and neural repair, Год журнала: 2023, Номер 37(7), С. 423 - 433

Опубликована: Июнь 23, 2023

Altered dynamic functional connectivity has been associated with motor impairments in the acute phase post-stroke. Its association somatosensory early sub-acute remains unexplored.To investigate altered post-stroke.We collected resting state magnetic resonance imaging and clinical function of upper limb 20 subacute stroke patients 16 healthy controls (HC). A sliding-window approach was used to identify 3 states based on estimated sensorimotor related networks. Network components were subdivided into domains: cortical subcortical sensorimotor, as well cognitive control network. Between-group differences investigated using independent t-tests Mann-Whitney-U tests. Analyzes performed correction for age, head motion time post-stroke corrected multiple comparisons.Stroke spent significantly less a weakly connected network (state 3; dwell time: pstate3 = 0.003, meanstroke 53.02, SDstroke 53.13; meanHC 118.92, SDHC 72.84), stayed shorter but more intervals highly intra-domain 1; fraction pstate 1 < 0.001, 0.46, 0.26; 0.26, 0.21) compared HC. After 8 weeks therapy, improvements wrist proprioception moderately decreases times toward normalized pattern.Changes temporal properties large-scale interactions are present rehabilitation could indicate enhanced neural plasticity. These findings augment understanding cerebral reorganization after loss tissue specialized functions.

Язык: Английский

---