Posterior cingulate cortex targeted real‐time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default‐mode network in PTSD

Brain and Behavior, Год журнала: 2023, Номер 13(3)

Опубликована: Фев. 15, 2023

Abstract Background Alterations within large‐scale brain networks—namely, the default mode (DMN) and salience networks (SN)—are present among individuals with posttraumatic stress disorder (PTSD). Previous real‐time functional magnetic resonance imaging (fMRI) electroencephalography neurofeedback studies suggest that regulating posterior cingulate cortex (PCC; primary hub of DMN) activity may reduce PTSD symptoms recalibrate altered network dynamics. However, PCC connectivity to DMN SN during PCC‐targeted fMRI remains unexamined help elucidate neurophysiological mechanisms through which these symptom improvements occur. Methods Using a trauma/emotion provocation paradigm, we investigated psychophysiological interactions over single session ( n = 14) healthy control 15) participants. We compared between regulate (in participants downregulated activity) view did not exert regulatory control) conditions across whole‐brain as well in priori specified regions‐of‐interest. Results During conditions, only group showed significant anterior (dmPFC, vmPFC) (posterior insula) regions, whereas both groups displayed other areas (precuneus/cuneus). Additionally, controls, significantly greater (amygdala) conditions. Moreover, linear regression analyses revealed regions was positively correlated psychiatric all Conclusion In summary, observations provide emerging evidence neural underlying PTSD. This supports use means by PTSD‐associated alterations SN, together, facilitate improved emotion regulation abilities

Язык: Английский

---

Increased top-down control of emotions during symptom provocation working memory tasks following a RCT of alpha-down neurofeedback in PTSD

NeuroImage Clinical, Год журнала: 2023, Номер 37, С. 103313 - 103313

Опубликована: Янв. 1, 2023

Posttraumatic stress disorder (PTSD) has been found to be associated with emotion under-modulation from the prefrontal cortex and a breakdown of top-down control cognition emotion. Novel adjunct therapies such as neurofeedback (NFB) have shown normalize aberrant neural circuits that underlie PTSD psychopathology at rest. However, little evidence exists for NFB-linked improvements under emotionally relevant cognitive load. The current study sought address this gap by examining effects alpha-down NFB in context an emotional n-back task. We conducted 20-week double-blind randomized, sham-controlled trial collected neuroimaging data before after protocol. Participants performed 1-back 2-back working memory task, interleaved trauma-neutral trauma-relevant cues fMRI scanner. Data 35 participants primary diagnosis were analyzed (n = 18 experimental group undergoing NFB, n 17 sham-control group). Firstly, within-group analyses showed clinically significant reductions symptom severity scores post-intervention timepoint 3-month follow-up group, not group. revealed enhanced engagement centers, dorsolateral (dlPFC), improved integration anterior posterior parts default mode network (DMN). Finally, our results also indicate increased performance correlated activity brain regions involved bodily consciousness/embodied processing self (TPJ insula). This is first provide mechanistic insights into how may dysfunctional connectivity load simultaneous provocation, adding growing body supporting therapeutic neuromodulatory NFB. preliminary highlights benefits training adjunctive therapy warrants further investigation its on those PTSD.

Язык: Английский

---

Inter-identity amnesia in dissociative identity disorder resolved: A behavioural and neurobiological study

Journal of Psychiatric Research, Год журнала: 2024, Номер 174, С. 220 - 229

Опубликована: Апрель 16, 2024

Dissociative identity disorder (DID) is characterised by, among others, subjectively reported inter-identity amnesia, reflecting compromised information transfer between dissociative states. Studies have found conflicting results regarding memory Here, we investigated amnesia in individuals with DID using self-relevant, subject specific stimuli, and behavioural neural measures.

Язык: Английский

---

The Functional Connectome and Long-Term Symptom Presentation Associated With Mild TBI and Blast Exposure in Combat Veterans

Journal of Neurotrauma, Год журнала: 2024, Номер unknown

Опубликована: Авг. 16, 2024

Mild traumatic brain injury (TBI) sustained in a deployment environment (deployment TBI) can be associated with increased severity of long-term symptom presentation, despite the general expectation full recovery from single mild TBI. The heterogeneity effects TBI on difficult for case-control design to capture. functional connectome is an approach robust that allows global measurement using common set outcomes. present study evaluates how differences relate remote presentation following combat and determines if TBI, blast exposure, or post-traumatic stress disorder (PTSD) are these neurological differences. Participants included 181 Iraq Afghanistan combat-exposed Veterans, approximately 9.4 years since deployment. Structured clinical interviews provided diagnoses characterizations PTSD. Self-report measures characterization symptoms (psychiatric, behavioral health, quality life). Resting-state magnetoencephalography was used characterize individually each participant. Linear regression identified factors contributing including relevant covariates, metrics, exposure PTSD, conditional relationships. Results unique contributions aspects presentation. Furthermore, several relationships were identified, demonstrating related outcomes presence only deployment-related (including blast-related primary exposure). No PTSD; however, main effect PTSD significant all models. These results demonstrate captures function highlighting influences through pathway. findings changes over decade past event, providing clear demonstration brain-based mechanism influence.

Язык: Английский

---

Systematic review and meta-analysis of neurofeedback and its effect on posttraumatic stress disorder

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Март 21, 2024

Background To date, only one systematic review and meta-analysis of randomized controlled trials (RCTs) has evaluated the effect neurofeedback in PTSD, which included four studies found an uncertainty EEG-NF on PTSD symptoms. This is update considering that numerous have since been published. Additionally, more recent fMRI-NF as well fMRI-guided or -inspired EEG NF Methods Systematic literature searches for RCTs were conducted three online databases. Additional hand each study identified reviews meta-analyses published also undertaken. Outcomes vs. a control (active, sham, waiting list) their effects reducing symptoms using various health instruments. Meta-analytical methods used inverse variance random-effects models measuring both mean standardized differences. Quality certainty evidence assessed GRADE. Adverse events evaluated. Results A total 17 evaluating 628 patients. There 10 meta-analysis. from all favored neurofeedback’s including BDI pretest–posttest [mean difference (MD): 8.30 (95% CI: 3.09 to 13.52; P = 0.002; I 2 0%)]; pretest–follow-up (MD: 8.75 3.53 13.97; < 0.00001; 0%); CAPS-5 [MD: 7.01 1.36 12.66; 0.02; 86%)]; 1.29 21.29; 0.006; 77%); PCL-5 7.14 3.08 11.2; 0.0006; 14.95 7.95 21.96; 0.0001; 0%). Other reported improvements other GRADE assessments CAPS, PCL, demonstrated moderate/high level quality positive clinical effect. Conclusion Based newer outcomes measured, clinically meaningful size, with increased size at follow-up. appears be driven by deeper brain derivates it.

Язык: Английский

---

Towards predicting posttraumatic stress symptom severity using portable EEG-derived biomarkers

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 13, 2025

Язык: Английский

---

Can Electroencephalography-Based Neurofeedback Treat Post-traumatic Stress Disorder? A Meta-analysis Study

Applied Psychophysiology and Biofeedback, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Язык: Английский

---

Neurofeedback for post-traumatic stress disorder: systematic review and meta-analysis of clinical and neurophysiological outcomes

European journal of psychotraumatology, Год журнала: 2023, Номер 14(2)

Опубликована: Сен. 21, 2023

Background: Posttraumatic stress disorder (PTSD) is a debilitating condition affecting millions of people worldwide. Existing treatments often fail to address the complexity its symptoms and functional impairments resulting from severe prolonged trauma. Electroencephalographic Neurofeedback (NFB) has emerged as promising treatment that aims reduce PTSD by modulating brain activity.

Язык: Английский

---

A tale of two targets: examining the differential effects of posterior cingulate cortex- and amygdala-targeted fMRI-neurofeedback in a PTSD pilot study

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Ноя. 29, 2023

Introduction Real-time fMRI-based neurofeedback (rt-fMRI-NFB) is a non-invasive technology that enables individuals to self-regulate brain activity linked neuropsychiatric symptoms, including those associated with post-traumatic stress disorder (PTSD). Selecting the target region for neurofeedback-mediated regulation primarily informed by neurobiological characteristics of participant population. There strong link between PTSD symptoms and multiple functional disruptions in brain, hyperactivity within both amygdala posterior cingulate cortex (PCC) during trauma-related processing. As such, previous rt-fMRI-NFB studies have focused on these two regions when training regulate neural activity. However, differential effects selection PTSD-related clinical outcomes not previously been investigated. Methods Here, we compared whole-brain activation changes participants ( n = 28) trained downregulate either 14) or PCC while viewing personalized trauma words. Results For as group, observed decreased several implicated psychopathology – namely, bilateral cuneus/precuneus/primary visual cortex, left superior parietal lobule, occipital pole, right temporal gyrus/temporoparietal junction (TPJ) downregulation using rt-fMRI-NFB. Conversely, there were no unique (i.e., over above group) decreases Importantly, was significantly improved whereas reduced reliving distress course this single session. In pilot analysis, did detect significant between-group differences state neurofeedback. critical control, groups differ their ability respective regions. This indicates subsequent results can be attributed terms neurophysiological function, rather than result group regulatory success. Conclusion study, differentially simultaneous PTSD-associated novel analysis may guide researchers choosing future help establish efficacy specific targets PTSD. A multi-session trial directly compares warranted.

Язык: Английский

---

Posttraumatic growth EEG neuromarkers: translational neural comparisons with resilience and PTSD in trauma-exposed healthy adults

European journal of psychotraumatology, Год журнала: 2023, Номер 14(2)

Опубликована: Ноя. 15, 2023

Supporting wellbeing beyond symptom reduction is necessary in trauma care. Research suggests increased posttraumatic growth (PTG) may promote more effectively than stress disorder (PTSD) alone. Understanding neurobiological mechanisms of PTG would support intervention development. However, most research to-date has been cross-sectional data self-reported through surveys or interviews.

Язык: Английский

---