Hypertension is associated with the reduction in epidermal small fibres independently of sural nerve inflammation in type 2 diabetic subjects DOI Creative Commons
Zhenchao Wang,

Hanae Kushibiki,

Takefusa Tarusawa

и другие.

Journal of Neurochemistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Diabetic polyneuropathy (DPN) is a multifactorial disease associated not only with hyperglycaemia but also circulatory disturbances such as hypertension. A close interaction between the immune system and hypertension known. It remains unclear whether inflammatory response in pathology of human DPN. Autopsied patients were evaluated: 7 non-diabetic (nDM), 11 (nDMHT), 6 diabetes (DM) 9 (DMHT). Intraepidermal nerve fibre density (IENFD) was examined by immunofluorescent staining. Dissected sural (SNs) morphometrically quantified. Dermal endoneurial macrophage infiltration evaluated double immunostaining using anti-CD68 anti-CD206 antibodies. IENFD significantly decreased DM compared to nDM (p < 0.05) further DMHT 0.05). Myelinated (MNFD) SN 0.01 vs. DM). The CD206

Язык: Английский

Moderate cryptoxanthin intake correlates with maintenance of a proper PINT index in a general Japanese population DOI Creative Commons

Masaki Ryuzaki,

Hiroki Mizukami, Yuki Takeuchi

и другие.

Nutritional Neuroscience, Год журнала: 2024, Номер unknown, С. 1 - 11

Опубликована: Июль 25, 2024

Small fibre neuropathy (SFN) is an early manifestation of diabetic polyneuropathy. Although oxidative stress, inflammation and change intestinal bacterial population are assumed to be their pathogenesis, the effects dietary nutrition have not been evaluated. The relationship between intake pain sensation was evaluated in Japanese population.

Язык: Английский

Процитировано

1
Hypertension is associated with the reduction in epidermal small fibres independently of sural nerve inflammation in type 2 diabetic subjects DOI Creative Commons
Zhenchao Wang,

Hanae Kushibiki,

Takefusa Tarusawa

и другие.

Journal of Neurochemistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Diabetic polyneuropathy (DPN) is a multifactorial disease associated not only with hyperglycaemia but also circulatory disturbances such as hypertension. A close interaction between the immune system and hypertension known. It remains unclear whether inflammatory response in pathology of human DPN. Autopsied patients were evaluated: 7 non-diabetic (nDM), 11 (nDMHT), 6 diabetes (DM) 9 (DMHT). Intraepidermal nerve fibre density (IENFD) was examined by immunofluorescent staining. Dissected sural (SNs) morphometrically quantified. Dermal endoneurial macrophage infiltration evaluated double immunostaining using anti-CD68 anti-CD206 antibodies. IENFD significantly decreased DM compared to nDM (p < 0.05) further DMHT 0.05). Myelinated (MNFD) SN 0.01 vs. DM). The CD206

Язык: Английский

Процитировано

0