Individualized Spectral Features in First-episode and Drug-naïve Major Depressive Disorder: Insights from Periodic and Aperiodic EEG Analysis.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

---

Catecholaminergic Modulation of Metacontrol Is Reflected in Aperiodic EEG Activity and Predicted by Baseline GABA+ and Glx Concentrations

Human Brain Mapping, Год журнала: 2025, Номер 46(4)

Опубликована: Март 1, 2025

The ability to balance between being persistent versus flexible during cognitive control is referred as "metacontrol" and reflected in the exponent of aperiodic neural activity. Theoretical considerations suggest that metacontrol affected by interplay GABAergic, glutamatergic, catecholaminergic systems. Moreover, evidence suggests fronto-striatal structures play an important role. Yet, nexus neurobiochemistry structural neuroanatomy when it comes foundations not understood. To examine this, we investigated how experimental manipulation signaling via methylphenidate (MHP) baseline levels GABA glutamate anterior cingulate cortex (ACC), supplementary motor area (SMA), striatum assessed MR spectroscopy altered task performance associated activity (assessed EEG) a conflict monitoring task. We N = 101 healthy young adults. show EEG-aperiodic was elevated performance, well cognitively challenging conditions requiring more processing further enhanced MPH administration. Correlation analyses also provided for role individual characteristics dispositions observed GABA+ Glx ACC, SMA, striatum. Our observations point catecholamines amino acid neurotransmitter-driven regulation task-specific (changes in) biases. results GABA/Glx system prefrontal-basal ganglia crucial metacontrol.

Язык: Английский

---

In vitro electrophysiological characterization of Parkinson’s disease: challenges, advances, and future directions

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Апрель 30, 2025

Parkinson's disease is the second most common neurodegenerative disorder, characterized by progressive loss of dopaminergic neurons in substantia nigra and accumulation α-synuclein aggregates. While significant progress has been made understanding genetic biological aspects disease, its complex pathophysiology remains poorly understood, current therapeutic approaches are largely symptomatic. Advanced vitro models have emerged as essential tools for studying related mechanisms developing new strategies. However, electrophysiological characterization these underexplored. This review highlights importance employing techniques, such patch-clamp recordings microelectrode arrays, providing critical insights into neuronal dysfunction, synaptic impairments, network disruptions disease. The aim to summarize key discoveries pathology recent years, underlying main challenges, including lack standardized protocols, heterogeneity cellular sources culture systems. Addressing limitations crucial improving reproducibility facilitating cross-study comparisons, allowing a deeper pathophysiology. By refining standardizing approaches, efforts will enhance our disease's mechanisms, ultimately accelerating discovery robust biomarkers development more effective

Язык: Английский

---

Metacontrol-related aperiodic neural activity decreases but strategic adjustment thereof increases from childhood to adulthood

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 26, 2025

Язык: Английский

---