Sleep on it!

Brain Communications, Год журнала: 2025, Номер 7(2)

Опубликована: Янв. 1, 2025

Our Associate Editor, Laurent Sheybani, discusses some very old and recent findings on sleep physiology function, hoping to raise further interest publications in the field.

Язык: Английский

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Functional dynamic network connectivity differentiates biological patterns in the Alzheimer's disease continuum

Neurobiology of Disease, Год журнала: 2025, Номер unknown, С. 106866 - 106866

Опубликована: Март 1, 2025

Alzheimer's disease (AD) can be conceptualized as a network-based syndrome. Network alterations are linked to the molecular hallmarks of AD, involving amyloid-beta and tau accumulation, consecutively neurodegeneration. By combining resting-state functional magnetic resonance imaging, we assessed whether different biological patterns AD identified through data-driven approach matched specific abnormalities in brain dynamic connectivity. We three main patient clusters. The first group displayed mild pathological alterations. second cluster exhibited typical behavioral impairment alongside pathology. third demonstrated similar but with divergent (low) neurodegeneration (high) profile. Univariate multivariate analyses revealed two connectivity encompassing default mode network occipito-temporal cortex, respectively atypical patterns. These results support key association between macro-scale Dynamic markers assist identifying patients AD-like clinical profiles underlying pathologies.

Язык: Английский

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Rethinking biological biomarkers to track treatment efficacy in Alzheimer's disease: Focus on brain connectivity

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(3)

Опубликована: Март 1, 2025

Язык: Английский

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Complex non‐Markovian dynamics and the dual role of astrocytes in Alzheimer’s disease development and propagation

Quantitative Biology, Год журнала: 2025, Номер 13(3)

Опубликована: Апрель 14, 2025

Язык: Английский

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